Navigation Links
Special issue of the EMBO Journal celebrates 30 years of Wnt research
Date:5/22/2012

HEIDELBERG, 22 May 2012 The impact and influence of thirty years of research into the Wnt/beta-catenin signaling pathway are highlighted in a special issue of The EMBO Journal. "Three decades of Wnt signalling" summarizes many of the crucial scientific developments that have taken place since the discovery of the first mammalian Wnt gene in 1982. The reviews also describe many of the crucial research findings that have established the pathway as one of the fundamental signal transduction mechanisms in development and disease.

Eric Wieschaus, Professor of Molecular Biology at the University of Princeton, remarked: "30 years ago, in the early days of Wnt research, no one anticipated how broadly the pathway would be utilized during development. We now know that Wnt signalling and the components of the Wnt pathway play a central role in patterning and cell fate in organisms from sea urchins to humans and operate in processes as diverse as stem cell maintenance, tissue polarity and neuronal development. We should not be surprised therefore by the parallel importance of the Wnt pathway in cancer and human disease."

Wnt-components and the signals they elicit have roles in many biological processes that range from cell behavior to the determination of cell fate. The discovery of the close relationship between the first mammalian Wnt gene, the int1 proto-oncogene, and the wingless gene in Drosophila provided an important early link between cancer biology and developmental genetics. Multidisciplinary research involving Drosophila geneticists, cancer biologists and molecular biologists, has facilitated the molecular dissection of Wnt pathways, establishing them as one of the first and best understood evolutionary conserved signaling mechanisms.

Today, the Wnt research community is bigger than ever, providing new insight into how cells interact to form a developing organism. This research is leading to the emergence of therapeutic approaches for the treatment of cancer.

Articles included in The EMBO Journal special issue include:

  • Three decades of Wnts: A personal perspective on how a scientific field developed by Roel Nusse, Harold Varmus

  • Adult mammalian stem cells: The role of Wnt, Lgr5 and R-spondins by Hans Clevers, Jurian Schuijers

  • Wnts in synapse formation and neuronal circuitry by Mikyoung Park, Kang Shen

  • Mitotic and mitogenic Wnt signaling by Christof Niehrs, Sergio P Acebrn

  • The many faces and functions of β-catenin by Konrad Basler, Tomas Valenta, George Hausmann

  • Drugging Wnt signaling in cancer by Paul Polakis

Bernd Pulverer, Head of Scientific Publications at EMBO and Chief Editor of The EMBO Journal, commented: "We are particularly pleased to present this collection of high-impact reviews to mark the occasion of the 30th anniversary of the discovery of the int1 proto-oncogene in the 30th anniversary year of The EMBO Journal. Both the journal and the Wnt research community have witnessed the emergence of a remarkable multidisciplinarity in molecular cell biology research. This notable progress has brought together previously disparate disciplines, including genetics, developmental biology, biochemistry, molecular biology, biophysics and systems biology, to form a vibrant integrative approach to biological research."


'/>"/>
Contact: Barry Whyte
barry.whyte@embo.org
49-622-188-91108
European Molecular Biology Organization
Source:Eurekalert

Related biology news :

1. So-called sandfish could help materials handling and process technology specialists
2. HJF nursing specialist wins prestigious Celina Field Cargiver Award
3. Neuroinformatics special issue spotlights the Neuroscience Information Framework
4. Special issue of BMC Microbiology spotlights standardized language for describing microbes
5. Special issue Comparative Cognition in Context now published
6. Explorations Group Announces Letter of Intent to Acquire Specialty Lighting Company
7. Explorations Group Announces Letter of Intent to Acquire Specialty Lighting Company
8. Pest management specialist Charles Summers wins prestigious Woodworth Award
9. GSA special paper presents new studies of Western US earth motion
10. Continuous glucose monitoring technology -- special issue of Diabetes Technology and Therapeutics
11. Women with endometriosis need special care during pregnancy to avoid risk of premature birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at VivaTech ... startups and global businesses, taking place in Paris ... will showcase the solutions they have built with IBM Watson ... France is one of the most dynamic ... in the number of startups created between 2012 and 2015*, ...
(Date:5/16/2017)... N.J. , May 16, 2017  Veratad Technologies, ... provider of online age and identity verification solutions, announced ... K(NO)W Identity Conference 2017, May 15 thru May 17, ... Regan Building and International Trade Center. ... the globe and in today,s quickly evolving digital world, ...
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... CA (PRWEB) , ... October ... ... (https://www.onramp.bio/ ) has launched Rosalind™, the first-ever genomics analysis platform specifically designed ... bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, who made ...
(Date:10/11/2017)... CA, USA (PRWEB) , ... October 11, 2017 , ... ... to take place on 7th and 8th June 2018 in San Francisco, CA. The ... influencers as well as several distinguished CEOs, board directors and government officials from around ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the ... million people each year. Especially those living in larger cities are affected by air ... one of the most pollution-affected countries globally - decided to take action. , “I ...
(Date:10/10/2017)... , ... October 10, 2017 ... ... cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing ... HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s ...
Breaking Biology Technology: