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Spatial knowledge vs. spatial choice: The hippocampus as conflict detector?
Date:7/19/2012

ng the NMDA receptors in the dentate gyrus and the CA1 region could not resolve this problem. If both beacons were removed or the shape of the decoy beacons was modified, all the animals quickly selected the location of the invisible platform.

"This clearly shows that, after a number of runs, even our genetically modified mice know the exact location of the hidden escape platform or can purposefully get their bearings in the swimming pool when searching for various beacons. Our mice therefore have no learning or memory problems in either of the two tasks. If, however, the tasks are temporally superimposed and if the location of identical beacons in the swimming pool does not have to be evaluated as distinct items of information, our mice are not capable of making the right decision to resolve the problem," says Rolf Sprengel.

The NMDA receptors in the CA1 region of the hippocampus therefore seem to perform a conflict detection or decision-making role in the event of conflicts.

This is an extremely surprising result. It runs contrary to a textbook tenet that has prevailed for more than 15 years, namely that NMDA receptors in the CA1 region of the hippocampus are needed to develop spatial memory. "Thanks to Rolf Sprengel's new complex genetic technique of switching off the NMDA receptors only in specific parts of the hippocampus in adult mice and to David Bannerman's intelligently linked behavioural experiments, we now know that NMDA receptors in other parts of the brain are probably responsible for learning spatial relations," explains Peter H. Seeburg. The researchers assume, therefore, that hippocampal NMDA receptors are also significant in other non-spatial conflicts.


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Contact: Dr. Rolf Sprengel
Rolf.Sprengel@mpimf-heidelberg.mpg.de
49-622-148-6101
Max-Planck-Gesellschaft
Source:Eurekalert  

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