Navigation Links
Spanish scientists identify a new ancestral enzyme that facilitates DNA repair
Date:11/20/2013

n, for example], the copy is interrupted and the process stops until the error is repaired. This interruption can cause breaks in the DNA, translocations of fragments from some chromosomes to others, and even cause cell death or malignant transformation", says Mndez.

The research carried out by CNIO and CSIC demonstrates that the PrimPol enzyme prevents the copying process from being interrupted when there is damage: it recognises lesions and skips over them, and they are repaired when the copy is finished.

In evolutionary terms, PrimPol is a very old enzyme, and similar proteins have been found in archaebacteria, one of the first life forms that inhabited the Earth. "Millions of years ago, life conditions were more difficult [high salinity, extreme temperatures, etc.], so PrimPol has probably adapted to synthesising DNA in these conditions that encourage damage", says Mndez, adding that: "in exchange, these primitive DNA polymerases are less exact than the more evolved copying systems and can introduce mutations".

The scientists anticipate that this increase in mutations could have played a key role in the evolution of genomes, as well as having an impact on the ageing of cells and the development of cancer. Having identified and characterised this new protein in human beings, the researchers tell us that they are already studying its role in disease development.


'/>"/>

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Page: 1 2

Related biology news :

1. EAU Patient Information now available in Spanish and Greek
2. A Spanish breakthrough allows the electroporation of cell cultures for less than 1 Euro
3. Spanish researchers design biomarkers for the detection of dengue and West Nile virus
4. Spanish consumers prefer national fish
5. Spanish scientist participate in the most comprehensive study ever done on ice
6. Spanish researcher releases a video showing a beetle from the inside
7. UT Dallas computer scientists create 3-D technique
8. Salk scientists for the first time generate mini-kidney structures from human stem cells
9. The Gorgons of the eastern Pacific: scientists describe 2 new gorgonian soft coral species
10. Bleeding symptom leads scientists to intracellular traffickers role in virus propagation
11. Patients and scientists join forces to tackle Friedreichs Ataxia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... NC Ancient DNA adds a twist to the story ... to be published April 21 in the journal Proceedings ... from the bones of chickens that lived 200-2300 years ago ... ago domestic chickens may have looked far different from the ... of the traits we associate with modern domestic chickens -- ...
(Date:4/18/2014)... led by a University of California, Riverside professor of ... Department of Defense grant to uncover fundamental design rules ... predictable design of light-weight, tough and strong advanced materials ... and animals, including the mantis shrimp, toucan and bamboo. ... over millions of years and coming up with design ...
(Date:4/17/2014)... inhibits RSV infection , Respiratory syncytial virus ... tract infections, generating life-threating illness in very young ... are limited. RSV enters host cells through the ... fusogenic bundle. Small interfering peptides that prevent bundle ... peptides are highly susceptible to degradation. In this ...
Breaking Biology News(10 mins):Ancient DNA offers clues to how barnyard chickens came to be 2Mantis shrimp, toucan and trilobite, oh my 2Mantis shrimp, toucan and trilobite, oh my 3JCI online ahead of print table of contents for April 17, 2014 2JCI online ahead of print table of contents for April 17, 2014 3JCI online ahead of print table of contents for April 17, 2014 4JCI online ahead of print table of contents for April 17, 2014 5JCI online ahead of print table of contents for April 17, 2014 6
... happened in 1973. Republican president Richard Nixon -- who the ... of quotas and restrictions" -- signed the Endangered Species Act ... issues -- and the rapid decline of charismatic creatures like ... the law 92-0. Sounding more Thoreauvian than Thatcherite, Nixon declared, ...
... boat owner recognises the dilemma: environmentally friendly or effective. ... a way of reconciling these two almost unattainable aims. ... biocides in the paint, it is possible to both ... the environmental impact. "It,s very easy to make ...
... Building on its extensive laboratory research using magnetically ... The Children,s Hospital of Philadelphia has just spun off ... By licensing its technology to VMI, a new company ... viable therapy, the Hospital aims to create a novel, ...
Cached Biology News:Dispatches from the edge of doom 2Dispatches from the edge of doom 3Dispatches from the edge of doom 4More effective and less risky when you paint the hull of your boat 2CHOP partners with Vascular Magnetics, Inc. to pursue commercial potential of blood vessel research 2CHOP partners with Vascular Magnetics, Inc. to pursue commercial potential of blood vessel research 3
(Date:1/15/2014)... , "The interface is the device," Nobel laureate ... properties to be found at the junctures where ... world of nanotechnology, the interfaces between layers of ... in such high-tech favorites as spintronics, high-temperature superconductors, ...
(Date:1/15/2014)... 15, 2014 Cynvenio, a cancer diagnostics ... the genomic analysis of tumor cells in the bloodstream, ... web-based cancer decision support application powered by CollabRx, Inc. ... ClearID™ genomic test, Therapy Finder will provide breast cancer ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 More than ... and about 1 in 3 seniors will die with ... ). These jaw-dropping figures have shocked many Americans into ... hopefully, help prevent these tragic age-related cognitive disorders. Jonathan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... throughput research solutions, today announced that Lupin Limited, one ... of Freeslate’s CM Protégé PharmD System for ... in Mumbai, India, is focused on a wide range ...
Breaking Biology Technology:A deeper look at interfaces 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3
... molecules that appear in the central region of ,macromolecules ... atom ,at their center that determines their specific function. ... molecular electronics lies in their "ease of transfer ,electrons ... the work at the Nanomaterials and Nanotechnology Research Center ...
... Pharmaceuticals, Inc. (Nasdaq: ANDS ) announced today that ... Friday, September 9, 2011 at 10:55 a.m. EDT (7:55 a.m. ... Hotel in Boston.  Steve Worland, Ph.D., President and Chief Executive ... its clinical development programs, setrobuvir and ANA773. Dr. ...
... (NYSE Amex: CUR ) announced that President ... Stifel Nicolaus Annual Healthcare Conference on Wednesday, September 7 ... opportunities and advancements in neural stem cell pharmaceuticals and ... the ongoing ALS trial at Emory University. ...
Cached Biology Technology:The quantum tunneling effect leads electron transport in porphyrins 2Anadys Pharmaceuticals to Present at Two Upcoming Investor Conferences 2Anadys Pharmaceuticals to Present at Two Upcoming Investor Conferences 3Neuralstem President and CEO to Present at the 2011 Stifel Nicolaus Annual Healthcare Conference 2Neuralstem President and CEO to Present at the 2011 Stifel Nicolaus Annual Healthcare Conference 3
... HyPer is the first fully genetically encoded ... of intracellular hydrogen peroxide (H2O2), one of ... on the basis of yellow fluorescent protein ... coli protein OxyR (OxyR-RD), HyPer demonstrates submicromolar ...
...
Formulation: Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide....
Mouse monoclonal [0.T.81] to Lac1 ( Abpromise for all tested applications). Antigen: Recombinant TrpE fusion protein containing full length E. coli Lac1....
Biology Products: