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Soy isoflavone may inhibit common gastrointestinal illness in infants
Date:9/6/2007

there is no additional inhibition or toxicity.

We then exposed the cells to different concentrations of rotavirus. If an infant had a severe infection or was exposed to a lot of rotavirus, we wondered if the isoflavones would still be as effective, she said.

The inhibition held up across a 16-fold range of rotavirus exposure. Even at the highest concentration of rotavirus particles, genistin or the mix of isoflavones inhibited infectivity, said Donovan.

Genistin appeared to diminish infectivity by inhibiting binding of the virus to tissue-culture cells, she said.

Donovans laboratory soon plans to begin studies with neonatal piglets, an excellent model for studying rotavirus infection and the nutritional effects of various components on the intestine.

Well be interested to see if we have the same results when we work with young animals, she said.


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Contact: Phyllis Picklesimer
p-pickle@uiuc.edu
217-244-2827
University of Illinois at Urbana-Champaign
Source:Eurekalert

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