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Soy germ-based supplement SE5-OH containing natural S-Equol examined for safety, hormonal influence
Date:4/1/2010

d not significantly differ in their menstrual cycle length prior to the study (p=0.59) or body mass (p=0.193), but did in age, averaging 30 in the placebo group and 24 in the SE5-OH group (p=0.024). Seven of the placebo group and five of the SE5-OH group were documented as equol producers (p=0.725), based on their equol levels after a soymilk challenge. This standard test for equol production in humans includes a three-day soy milk challenge followed by measures of urinary equol concentration on day four of the test. The women also were not taking any antibiotics.

During the 12-week post-menopausal study, the 27 women in the treatment group took Natural S-equol. The 54 women, aged 44 to 64, had reached menopause an average of five years prior to enrollment. None of the women naturally produced equol. The two treatment groups did not differ by average age or body mass index.

"These studies demonstrated that SE5-OH containing Natural S-equol is safe as measured and well tolerated in post-menopausal women fed the supplement for 12 weeks and in pre-menopausal women fed the supplement for one month. These studies were designed to better understand the impact and safety of SE5-OH with Natural S-equol in these two populations of women, and the findings indicate that there are no short-term safety concern based on the measures included in the study of certain hormone levels, endometrium thickness and menstrual cycle durations. These studies were conducted in preparation for the development of a women's health supplement designed to provide benefits for the management of menopausal symptoms. Further studies are needed to confirm whether or not fermented soy food containing Natural S-equol has influence when consumed for longer time periods or at higher doses," Jenks said.


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Contact: Stephen McCauley
smccauley@porternovelli.com
202-973-3615
Porter Novelli
Source:Eurekalert

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