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Soy germ-based supplement SE5-OH containing natural S-Equol examined for safety, hormonal influence
Date:4/1/2010

SE5-OH containing Natural S-equol tablets and placebos.

Endometrium thickness not influenced by SE5-OH containing Natural S-equol in post-menopausal women

In the post-menopausal women's study, the average thickness of the uterus' inner tissue lining, the endometrium, did not significantly differ between those women receiving a placebo or SE5-OH containing Natural S-equol.

As a normal part of the menstrual cycle, the hormone estrogen exerts influence to prompt the growth and thickening of the endometrium, to help create a receptive environment for a fertilized egg. When the ovary releases an unfertilized egg, it also produces the hormone progesterone. Progesterone also influences the endometrium to prepare for pregnancy. However, if fertilization does not occur, the progesterone level drops and the endometrium is shed from the uterus, a process called menstruation. The cycle repeats about every 28 days until menopause, when menstruation ceases.

Menstrual cycle length in pre-menopausal women not influenced by SE5-OH containing Natural S-equol

In the pre-menopausal women's study, the menstrual cycle length remained normal and did not significantly differ between the groups of women receiving SE5-OH containing Natural S-equol or placebo, based on the average duration of their cycles in the four weeks before treatment, the four weeks during treatment and the four weeks after treatment.

In each of the two studies, the women in the placebo group did not differ from the women in the group receiving SE5-OH with Natural S-equol group in their reports of adverse effects, which included were diarrhea and feelings of fullness.

About the two studies

During the 12-week pre-menopausal study, the 18 women in the treatment group took Natural S-equol for four weeks, weeks 5 through 8 of the study. The 36 women, aged 20 to 38, had normal and regular menstrual cycles prior to enrollment. The women di
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Contact: Stephen McCauley
smccauley@porternovelli.com
202-973-3615
Porter Novelli
Source:Eurekalert

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