Navigation Links
South African daffodils may be a future cure for depression
Date:6/22/2012

Scientists at the University of Copenhagen have previously documented that substances from the South African plant species Crinum and Cyrtanthus akin to snowdrops and daffodils have an effect on the mechanisms in the brain that are involved in depression. This research has now yielded further results, since a team based at the Faculty of Health and Medical Sciences has recently shown how several South African daffodils contain plant compounds whose characteristics enable them to negotiate the defensive blood-brain barrier that is a key challenge in all new drug development.

"Several of our plant compounds can probably be smuggled past the brain's effective barrier proteins. We examined various compounds for their influence on the transporter proteins in the brain. This study was made in a genetically-modified cell model of the blood-brain barrier that contains high levels of the transporter P-glycoprotein. Our results are promising, and several of the chemical compounds studied should therefore be tested further, as candidates for long-term drug development," says Associate Professor Birger Brodin.

"The biggest challenge in medical treatment of diseases of the brain is that the drug cannot pass through the blood-brain barrier. The blood vessels of the brain are impenetrable for most compounds, one reason being the very active transporter proteins. You could say that the proteins pump the drugs out of the cells just as quickly as they are pumped in. So it is of great interest to find compounds that manage to 'trick' this line of defence."

The results of the study have been published in the Journal of Pharmacy and Pharmacology.

New cooperation between biologists and organic chemists

It will nonetheless be a long time before any possible new drug reaches our pharmacy shelves:

"This is the first stage of a lengthy process, so it will take some time before we can determine which of the plan
'/>"/>

Contact: Associate Professor Birger Brodin
bbr@farma.ku.dk
45-22-48-03-55
University of Copenhagen
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Mesquite trees displacing Southwestern grasslands
2. FirstMark Announces New Hire Jay Houtman as Southeast Regional Sales Manager
3. Southampton researchers lead 2 international projects to help people out of poverty
4. Bark beetle management and ecology in southern pine forests
5. Beetle-fungus disease threatens crops and landscape trees in Southern California
6. Latest Southern Ocean research shows continuing deep ocean change
7. Herbivores select on floral architecture in a South African bird-pollinated plant
8. CU-Boulder-led team finds microbes in extreme environment on South American volcanoes
9. UNH researchers find African farmers need better climate change data to improve farming practices
10. Treatment to benefit African infants at risk of endemic fever
11. African scientist, designer partner to fashion anti-malaria garment that wards off bugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
South African daffodils may be a future cure for depression
(Date:9/30/2014)... 2014  Spectra Automation, a trusted supplier ... and power generation industries, announced today the ... an easy-to-use and cost-effective data collection, analysis ... laboratories. Most upstream process ... systems. Accessing and consolidating data from these ...
(Date:9/29/2014)... study confirms that the exposure to tar tended to ... regular cigarettes. Similarly, exposure to nicotine tended to ... type of cigarette in several countries around the world. ... toxic chemicals in the smoke of these cigarettes are ... levels of chemicals in the smoke are not necessarily ...
(Date:9/29/2014)... at home should use ventilation when cooking with a ... after a new study showed an association between gas ... bronchitis. , "In homes where a gas stove was ... is higher than in homes where a gas stove ... professor in the College of Public Health and Human ...
Breaking Biology News(10 mins):Spectra Automation Introduces RECONN Bioprocess Manager 2Slim cigarette smokers not exposed to more harmful chemicals 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3
... about food security, the U.S. Agency for International ... Virginia Tech,s Office of International Research, Education, and ... barriers in Africa. The African Food Security ... focus on enhancing production of staple food commodities, ...
... the number of bees and other pollinators is not, ... the results of an international study published in the ... Biology . , Co-author, CSIRO Entomology,s Dr Saul ... that demand for pollinators is still growing and some ...
... leading five projects within the VII Framework ... cement materials, nanomaterials for building safer aircraft, ... fisheries resources and new models of production. ... with leading companies in their activity sectors ...
Cached Biology News:USAID grant awarded to improve food security in Africa 2Pollinator decline not reducing crop yields just yet 2TECNALIA leads five projects within the VII Framework Program 2
(Date:9/30/2014)... in German . ... dots in a semiconductor layer. Quantum dots are small structures ... If a short laser pulse is fired at the photonic ... experiences a change in the electromagnetic field around it. This ... light by the dot. As soon as the refractive index ...
(Date:9/30/2014)... NEW YORK , Sept. 30, 2014 /PRNewswire/ ... Review - 2014 Summary Global Markets ... Review - 2014, provides an overview of the ... focus. This report provides comprehensive information on ... Biotechnology, LLC,s, complete with comparative analysis at various ...
(Date:9/30/2014)... Over the last decade, the laboratory filtration market ... and increased acceptance of new filtration technologies in end ... are also catalyzing the growth of laboratory filtration market. ... grow at a strong CAGR during the forecast period ... million by 2019. The market is mainly driven by ...
(Date:9/30/2014)... -- CORD:USE Cord Blood Bank – www.corduse.com ... into an Equity and Exclusive Services Agreement with Tianhe Stem ... patented technologies for the isolation of human cord blood-derived ... performing Phase I/II clinical trials in China ... Tianhe,s Stem Cell Educator Therapy showing that the therapy ...
Breaking Biology Technology:Ultrafast remote switching of light emission 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4
... , , , , , , Multiporator , , , ... Transfection Protocol , Protocol No. 4308 915.035 12/1999 ... , , , , , ... , days in culture, , ...
... , , , , , , , ... Protocol No. 4308 915.528 01/2002 , , , , , ... , Microorganism , Pseudomonas aeruginosa, ... Bacteria, gram negative, , , ...
... , , Multiporator / Electroporator 2510 , , , , , , ... Transformation Protocol , Protocol No. 4308 915.526 01/2002 , , ... , , , Microorganism , ... Cell type , Bacteria, gram positive, ...
Cached Biology Technology:Primary cells, rat heart muscle 2Pseudomonas aeruginosa 2Nocardia corallina 2
... jetSI-ENDO-FluoR is a tetramethylrhodamine-conjugated ... emission at 580 nm), the ... reagents are used to determine ... the intracellular delivery and trafficking ...
... Bruker Daltonics and Bruker BioSpins Metabolic ... metabolism studies, and analysis of complex ... system, an optional Avance NMR spectrometer ... evaluation and statistical analysis for applications ...
... of Tracker, plus software to note when the ... a food reward.The Spatial Behavior line is a ... camera, frame grabber, and feature extraction software and ... up to 6 moving animals. Software automatically ...
... Tracker w/ OutputCumulates a score of movement ... except that it.can track up to 6 subjects ... can be triggered. Can outpt a sync ... EEG. Can use animal location and timing ...
Biology Products: