Navigation Links
Source identification of H7N9 influenza virus causing human infections
Date:4/24/2013

enza viruses, sharing 95.2󈟋.8% homology at the nucleotide level. The NA gene of the novel H7N9 virus isolates shared highest homology (97.3󈟍.9%) with NA genes from H4N9 or H11N9 influenza viruses isolated from ducks, and environmental samples from duck farms, located in the Dongting Lake region. It is clear that the novel H7N9 viruses are the product of gene reassortment, with the internal genes from one donor, and HA and NA genes from one or several other donors.

HA receptor-binding specificity is a major molecular determinant for the host range of influenza viruses. Amino acids at positions 226 and 228 of HA are critical for specificity of receptor-binding in influenza viruses. Within the HA protein of novel H7N9 viruses, there was a leucine residue at position 226, which is characteristic of the HA gene in human influenza viruses. This finding implies that H7N9 viruses have partially acquired human receptor-binding specificity. All of the H7N9 human isolates examined contained a lysine residue at position 627 in the PB2 protein. It is well known that this lysine residue contributes to the replication and transmission of avian influenza viruses in mammalian hosts. It is likely that the acquisition of this lysine in H7N9 viruses during their replication in human hosts has significantly contributed to their virulence and lethality in humans.

Tracing the source of these novel H7N9 influenza viruses, and their subsequent characterization, was a collaborative effort involving researchers from the National Avian Influenza Reference Laboratory at the Harbin Veterinary Research Institute, and Shanghai Animal Disease Control Center. This research project was partially supported by the National Basic Research Program of China (2011CB505000), the China Agriculture Research System (CARS-42-G08), and the National Science and Technology Major Project (2012ZX10004214). We suggest that strong measures, such as continued surveillance of avian and
'/>"/>

Contact: YAN Bei
yanbei@scichina.org
86-106-400-8316
Science China Press
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Collaboration to establish new computational resources for metabolomics
2. Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment
3. Microalgae could be a profitable source of biodiesel
4. Education resource focuses on teaching population genetics using current research
5. Pesticide application as potential source of noroviruses in fresh food supply chains
6. Assembling the transcriptome of a noxious weed: New resources for studying how plants invade
7. Report: Water and Agriculture in Canada: Towards Sustainable Management of Water Resources
8. Stem cell source an important factor, impacting ability to treat myocardial infarction
9. Hastings Center resources chart progress in debate over medical research with animals
10. Nitrogen from pollution, natural sources causes growth of toxic algae, study finds
11. Marginal lands are prime fuel source for alternative energy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has ... Market 2015-2019" report to their offering. ... grow at a CAGR of 23.5 percent over the ... scenario and the growth prospects of the Global Iris ... market size, the report considers the revenue generated from ...
(Date:3/23/2015)... March 23, 2015   HOYOS Labs , a ... today announced that the Company will demonstrate multiple biometrics-based ... and consumers at Connect:ID on March 23 through 25, ... Labs will highlight the IEEE Biometric Open Protocol Standard; ... and enterprise access control system. BOPS was invented by ...
(Date:3/20/2015)... OXFORD, Conn. , March 20, 2015 ... "Company"), a biometric authentication company focused on the growing ... Wocket® smart wallet is one of the products featured ... today, March 20th at 11:00 PM EST on the ... travels to Las Vegas , site ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3
... Medical Center clinical researchers will present findings about a ... Francisco at the Interscience Conference on Antimicrobial Agents and ... research team is presenting data in two poster presentations ... killing 99.9 percent of infectious airborne germs. Findings from ...
... to newly placed sod may result in nutrient runoff into ... to apply fertilizer and what kind is the best for ... team of scientists from Texas A&M AgriLife Research: Dr. Jacqui ... Ben Wherley, assistant professor of turfgrass science and ecology; Dr. ...
... principal cause of global warming? A new study by two ... keeps sea urchins in check will in turn allow kelp forests to ... amount of CO 2 from the atmosphere than if it were ... theory is outlined in a paper released online today (September 7, 2012) ...
Cached Biology News:Research finds novel airborne germ-killing oral spray effective in fighting colds and flu 2Turf study to monitor runoff, establish fertilizer management practices 2UC Santa Cruz study shows how sea otters can reduce CO2 in the atmosphere 2
(Date:4/30/2015)... (PRWEB) April 30, 2015 Clinovo ... 2015 PharmaSUG Annual Conference held in Orlando, FL ... Staffing Solutions along with Leslie Kolman, Manager of Staffing ... latest Clinovo news at Booth #17. , “We ... Conference again this year”, Says Trisha Heredia, Senior Director ...
(Date:4/29/2015)... USA (PRWEB) April 29, 2015 ... sensing, and imaging on the East Coast, reaffirmed its ... managers, researchers, applications developers, and industry suppliers to meet ... imaging for multiple applications. , The event included 55 ... commercial and scientific sensing and imaging -- and an ...
(Date:4/29/2015)... N.J. , April 29, 2015 Cambrex Corporation ... results will be released on Friday, May 1, 2015 before ... The Company will host a conference call to ... When: , Friday, May 1, ... , 1-888-468-2440 for U.S.1-719-325-2454 for International  Passcode:  7993632 ...
(Date:4/29/2015)... Gene therapy can clip out genetic material ... gene in human cardiac cells, according to a study led ... of Medicine at Mount Sinai. The study is published in ... mutations, the small random, changes in the genetic code making ... seen in patients with heart failure,” says Roger J. Hajjar, ...
Breaking Biology Technology:Clinovo Exhibits at the 2015 PharmaSUG Annual Conference on May 17-20th in Orlando, FL 2Clinovo Exhibits at the 2015 PharmaSUG Annual Conference on May 17-20th in Orlando, FL 3SPIE DSS provides venue for collaboration vital to research, applications advances 2SPIE DSS provides venue for collaboration vital to research, applications advances 3SPIE DSS provides venue for collaboration vital to research, applications advances 4Gene Therapy Clips Out Heart Failure Causing Gene Mutations 2Gene Therapy Clips Out Heart Failure Causing Gene Mutations 3Gene Therapy Clips Out Heart Failure Causing Gene Mutations 4
... Jan. 24 Quintiles,Transnational Corp. today announced the ... support the company,s continued,growth under the leadership of ... and the management team. Gillings and global private,investment ... the lead,investors in Quintiles, with 3i also becoming ...
... of chemistry and biochemistry at The University of Texas ... Chemistry jointly with Professor William Moerner of Stanford University. ... Professor Yuli Tamir, was given to the two scientists ... single-molecule spectroscopy and imaging. , The $100,000 prize will ...
... ... - Non-GAAP Diluted EPS Up 15%, GAAP Diluted ... VARI) today reported first quarter 2008 revenues of $237.4,million, representing an increase ... year 2007. The increase was broad-based,with growth in sales of products for ...
Cached Biology Technology:Quintiles Completes Previously Announced New Investor Partnership, Co-Led by Founder, Chairman and CEO Dennis Gillings, Bain Capital, TPG and 3i 2Quintiles Completes Previously Announced New Investor Partnership, Co-Led by Founder, Chairman and CEO Dennis Gillings, Bain Capital, TPG and 3i 3Varian, Inc. Reports First Quarter 2008 Results 2Varian, Inc. Reports First Quarter 2008 Results 3Varian, Inc. Reports First Quarter 2008 Results 4Varian, Inc. Reports First Quarter 2008 Results 5Varian, Inc. Reports First Quarter 2008 Results 6Varian, Inc. Reports First Quarter 2008 Results 7Varian, Inc. Reports First Quarter 2008 Results 8Varian, Inc. Reports First Quarter 2008 Results 9Varian, Inc. Reports First Quarter 2008 Results 10Varian, Inc. Reports First Quarter 2008 Results 11Varian, Inc. Reports First Quarter 2008 Results 12Varian, Inc. Reports First Quarter 2008 Results 13Varian, Inc. Reports First Quarter 2008 Results 14Varian, Inc. Reports First Quarter 2008 Results 15Varian, Inc. Reports First Quarter 2008 Results 16Varian, Inc. Reports First Quarter 2008 Results 17Varian, Inc. Reports First Quarter 2008 Results 18
B-FABP (FL-132)...
... Phosphatase ( l-PPase) is ... with activity towards phosphorylated ... residues. It is the ... the ORF221 open reading ...
... Innovative HL-2000 HybriLinker combines the benefits of a ... self-contained, space saving unit. , ... Laboratory allows crosslinking ,and hybridization at one location ... HL-2000 operate independently of each other , ...
... traps a wide variety of solvent vapors that ... glass condensation flask (GCF400) allows for the collection ... easy draining. Rapid cooling time minimizes waiting period., ... quick solvent changes , -50?C ...
Biology Products: