Navigation Links
Sons of cocaine-using fathers may resist addiction to drug, Penn Medicine study suggests
Date:11/11/2013

SAN DIEGO A father's cocaine use may make his sons less sensitive to the drug and thereby more likely to resist addictive behaviors, suggests new findings from an animal study presented by Penn Medicine researchers at Neuroscience 2013, the annual meeting of the Society for Neuroscience.

The study, led by Mathieu Wimmer, PhD, a post-doctoral researcher in the laboratory of R. Christopher Pierce, PhD, associate professor of Neuroscience in Psychiatry at the Perelman School of Medicine at the University of Pennsylvania, found that sons, but not females, of male rats on cocaine were not only less likely to want the drug, but also resistant to effects of it. This suggests cocaine causes epigenetic changesthat is alterations to DNA that do not involve changing the sequencein sperm in which reprogrammed information is transmitted down to the next generation of men.

Last year, Dr. Pierce and colleagues found that cocaine abuse in a male rat rendered the next generation of animals resistant to the rewarding properties of the drugthose offspring were less likely to take cocaine. They found changes in the brain-derived neurotrophic factor (BDNF), which is a molecule known to be important for the rewarding efficacy of cocaine, but only by looking at molecular signaling pathways in progeny that had never experienced cocaine.

In the current study, the authors focused on the physiology of neurons before and after taking cocaine in the offspring of cocaine-experienced fathers, and found that they were less sensitive to the drug and less likely to succumb to addictive behaviors.

In short, not only are rat offspring of cocaine-abusing fathers less likely to take the drug on their own volition, they are less likely to become addicted to it if they are administered it.

In male rats whose fathers used cocaine, the neurons in the nucleus accumbens were less sensitive to cocaine. That is, repeated cocaine use in the sons of cocaine-e
'/>"/>

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. First paternity study of southern right whales finds local fathers most successful
2. The old primates club: Even male monkeys ride their fathers coattails to success
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. BRG1 mutations confer resistance to hormones in lung cancer
5. Genetic variation in East Asians found to explain resistance to cancer drugs
6. Team discovers how bacteria resist a Trojan horse antibiotic
7. New paper examines poison resistance in snakes around the world
8. Hot on the trail of metabolic diseases and resistance to antibiotics
9. Notre Dame researchers using novel method to combat malaria drug resistance
10. MicroRNA controls malignancy and resistance of breast cancer cells
11. Scientists discover new type of cell with a key role in treatment-resistant asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/8/2015)... , July 8, 2015  Trovagene, Inc. (NASDAQ: ... diagnostics, today announced the launch of a study ... Precision Cancer Monitoring℠ (PCM) technology for predicting response ... or a combination of the novel immunotherapy agents ... a PD-1 inhibitor. The 50-patient study will be ...
(Date:7/7/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") a ... a revised version of one of its first 30 second commercials ... in New York , Chicago ... Francisco metro areas.    , , , ... all the cards in your wallet and keep your identity secure. ...
(Date:6/30/2015)... To bolster its efforts and commitment to fighting ... the addition of two new team members. ... David Raviv will act as head of strategic ... to providing the most secure solutions for the enterprise market. ... 7 Technologies, a provider of security and management products, which ...
Breaking Biology News(10 mins):Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 3HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3
... in pharmacies and health stores, phosphatidylserine is a natural ... to improve cognition and slow memory loss, it,s a ... a team headed by Prof. Gil Ast and Dr. ... Human Molecular Genetics have discovered that the same ...
... largest scientific society, invites news media coverage of its ... Indianapolis, Ind. It will take place at the Indiana ... than 7,100 presentations on new discoveries that span science,s ... will offer print, broadcast and online journalists a rich ...
... the path of insulin action in cells in precise detail ... what goes wrong in diabetes. The breakthrough study, ... Garvan Institute of Medical Research, is now published in the ... . First discovered in 1921, the insulin hormone plays ...
Cached Biology News:Common food supplement fights degenerative brain disorders 2Insight into the dazzling impact of insulin in cells 2Insight into the dazzling impact of insulin in cells 3
(Date:7/30/2015)... (PRWEB) , ... July 31, 2015 , ... Ralco is ... Center at the Lyon County Fair to be held August 5-9 in Marshall. The ... where their meals come from and how agriculture impacts their daily lives. This unique ...
(Date:7/30/2015)... France and Dallas, TX, USA (PRWEB) , ... ... ... of innovative nano and microsystems, has appointed Francois Vieillard as Sales & Marketing ... Marketing at executive positions, Francois Vieillard will be responsible for reinforcing Tronics’ business ...
(Date:7/30/2015)... ... July 30, 2015 , ... ... a field clinical study of its canine osteoarthritis stem cell product, currently under ... (Kansas City, KS) and will be marketed in the US by Aratana. This ...
(Date:7/30/2015)... -- With over 60,000 customers across the globe, ISN improves the efficiency and effectiveness of ... than 60,000 safe and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More ... Headquartered in Dallas, TX , ISN has additional offices ...
Breaking Biology Technology:Ralco Announces Primary Sponsorship of Ralco Enrichment Center at Lyon County Fair 2Tronics appoints Francois Vieillard as Sales and Marketing Director 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3
... 14 For 88 percent of,companies, front-line and ... cover a variety of development skills but focus,strongly ... Yet only half of executive-level sales leaders ... leadership development and,training, according to a member-driven research ...
... April 14 eResearchTechnology,Inc. (eRT), (Nasdaq: ... today their,alliance to provide integrated Cardiac Safety ... worldwide., eResearchTechnology is a leading provider ... other services,to the pharmaceutical, biotechnology, medical device, ...
... Corporation,(Pink Sheets: PHCP) (the "Company") clarified today that ... connection with,market transactions and are a valid representation ... This clarification was issued in response to,information from ... firms,will not negotiate Phlo common stock certificates issued ...
Cached Biology Technology:Developing Sales Leaders: Benchmarks Reveal Tactics that Will Propel Your Business 2eResearchTechnology, Inc. and nSpire Health, Inc. Form Alliance to Deliver Integrated Cardiac Safety and Pulmonary Clinical Trial Services 2eResearchTechnology, Inc. and nSpire Health, Inc. Form Alliance to Deliver Integrated Cardiac Safety and Pulmonary Clinical Trial Services 3Phlo Clarifies That Pre-Reverse Split Certificates Are Negotiable in Market Transactions 2
...
...
... I-96 Plate can be used either in ... large-scale (i.e., 96-well) purification of DNA and/or ... unique silica-based matrix make it perfect for ... RNA in = 10 l eluate per ...
Request Info...
Biology Products: