Navigation Links
Sons of cocaine-using fathers may resist addiction to drug, Penn Medicine study suggests
Date:11/11/2013

SAN DIEGO A father's cocaine use may make his sons less sensitive to the drug and thereby more likely to resist addictive behaviors, suggests new findings from an animal study presented by Penn Medicine researchers at Neuroscience 2013, the annual meeting of the Society for Neuroscience.

The study, led by Mathieu Wimmer, PhD, a post-doctoral researcher in the laboratory of R. Christopher Pierce, PhD, associate professor of Neuroscience in Psychiatry at the Perelman School of Medicine at the University of Pennsylvania, found that sons, but not females, of male rats on cocaine were not only less likely to want the drug, but also resistant to effects of it. This suggests cocaine causes epigenetic changesthat is alterations to DNA that do not involve changing the sequencein sperm in which reprogrammed information is transmitted down to the next generation of men.

Last year, Dr. Pierce and colleagues found that cocaine abuse in a male rat rendered the next generation of animals resistant to the rewarding properties of the drugthose offspring were less likely to take cocaine. They found changes in the brain-derived neurotrophic factor (BDNF), which is a molecule known to be important for the rewarding efficacy of cocaine, but only by looking at molecular signaling pathways in progeny that had never experienced cocaine.

In the current study, the authors focused on the physiology of neurons before and after taking cocaine in the offspring of cocaine-experienced fathers, and found that they were less sensitive to the drug and less likely to succumb to addictive behaviors.

In short, not only are rat offspring of cocaine-abusing fathers less likely to take the drug on their own volition, they are less likely to become addicted to it if they are administered it.

In male rats whose fathers used cocaine, the neurons in the nucleus accumbens were less sensitive to cocaine. That is, repeated cocaine use in the sons of cocaine-experienced fathers did not cause remodeling of excitatory AMPA receptors, which is thought to be critical for the development of addiction and cocaine craving.

"This adds to the growing body of evidence that cocaine abuse in a father rat can affect how his sons may respond to the drugand point to potential mechanisms that contribute to this phenomenon," said Wimmer. "Further research is needed to better understand how these behavior changes are passed down from one animal generation to the next, and eventually if the same holds true for humans."


'/>"/>

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine
Source:Eurekalert

Related biology news :

1. First paternity study of southern right whales finds local fathers most successful
2. The old primates club: Even male monkeys ride their fathers coattails to success
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. BRG1 mutations confer resistance to hormones in lung cancer
5. Genetic variation in East Asians found to explain resistance to cancer drugs
6. Team discovers how bacteria resist a Trojan horse antibiotic
7. New paper examines poison resistance in snakes around the world
8. Hot on the trail of metabolic diseases and resistance to antibiotics
9. Notre Dame researchers using novel method to combat malaria drug resistance
10. MicroRNA controls malignancy and resistance of breast cancer cells
11. Scientists discover new type of cell with a key role in treatment-resistant asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)... Feb. 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ) announces the ... Joey Fatone . Las Vegas , where ... --> Las Vegas , where Joey appeared at ... The new video ad was filmed at the Consumer Electronics Show (CES2016) ... Wocket booth to meet and greet fans. --> ...
(Date:1/22/2016)... January 22, 2016 ... addition of the  "Global Behavioral Biometric ... --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has ... Behavioral Biometric Market 2016-2020"  report to ... and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced ...
(Date:1/20/2016)... JOSE, Calif. , Jan. 20, 2016 /PRNewswire/ ... developer of human interface solutions, today announced sampling ... controller solution for wearables and small screen applications ... such as printers. Supporting round and rectangular shapes, ... S1423 offers excellent performance with moisture on screen, ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... New FDA action date of July 22, 2016 ... 22, 2016   --> - New ... - Lifitegrast has the potential to be the only product ... signs and symptoms of dry eye disease in adults --> ... in the U.S. in the past decade indicated for the treatment of signs ...
(Date:2/4/2016)... , Feb. 4, 2016 Beike Biotechnology, the ... medical institutions attended a ceremony in late 2015 to ... cell therapy in 2016. --> ... Translation Platform for Personalized Cell Therapy" was hosted by ... Production Center, both subsidiaries of Beike Biotechnology Co., Ltd. ...
(Date:2/4/2016)... , Feb. 4, 2016 ContraVir Pharmaceuticals, Inc. ... the development and commercialization of targeted antiviral therapies, announced ... Investor Conference 2016, to be held February 8-9, 2016, ... Group,s 2016 Disruptive Growth & Healthcare Conference, taking place ... 10-11, 2016. James Sapirstein , Chief Executive ...
(Date:2/4/2016)... 4, 2016 Strasbourg, France ... --> Strasbourg, France , to the ... PharmaVentures is pleased to announce that it acted as an ... unit in Strasbourg, France , to the ... --> --> Transgene (Euronext: TNG), a member ...
Breaking Biology Technology: