Navigation Links
Some immune cells defend only 1 organ
Date:4/17/2014

Scientists have uncovered a new way the immune system may fight cancers and viral infections. The finding could aid efforts to use immune cells to treat illness.

The research, in mice, suggests that some organs have the immunological equivalent of "neighborhood police" specialized squads of defenders that patrol only one area, a single organ, instead of an entire city, the body.

Scientists at Washington University School of Medicine in St. Louis have shown that the liver, skin and uterus each has dedicated immune cells, which they call tissue-resident natural killer cells. Other organs may have similar arrangements.

Their study, published in eLife, disproves the long-held assumption that all natural killer cells roam the body to provide the first line of defense against cancers and viruses.

"If, for example, we can use specialized medications to activate only these organ-specific cells, they could provide powerful and selective weapons against infections and tumors in the organs where they reside," said senior investigator Wayne M. Yokoyama, MD, the Sam and Audrey Loew Levin Professor of Medicine. "Cells that only defend one organ may be much better equipped than the roaming immune cells to mount an attack and limit collateral damage to healthy tissue."

Scientists have thought that mature natural killer cells circulate through the body looking for viruses and cancers. When these immune cells identify a threat, they attack. Scientists also thought that natural killer cells that stayed in the liver instead of circulating were immature or inactive and eventually would become like other natural killer cells, leaving the liver and moving through the body.

In the new study, lead author Dorothy K. Sojka, PhD, a postdoctoral research fellow in Yokoyama's laboratory, showed that some natural killer cells never leave the liver. She identified additional tissue-resident natural killer cells in the skin and uter
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. New method isolates immune cells for researchers to study how they ward off oral diseases
2. Sensitive balance in the immune system
3. La Jolla Institute discovers new mechanism for unleashing immune system against cancer
4. Immune cell defenders could beat invading bacteria
5. Newly discovered molecule may offer hope for immune disorders and runaway inflammation
6. IRCM researchers uncover a new function for an important player in the immune response
7. Study finds that fast-moving cells in the human immune system walk in a stepwise manner
8. An inventive new way to profile immune cells in blood
9. Scientists learn how pathogens hack our immune systems to go undetected
10. Study in mice raises question: Could PTSD involve immune response to stress?
11. Vitamin A used in acne medicines may help autoimmune and transplant patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2015)... , Aug. 19, 2015  VOXX International Corporation ... has entered into a Definitive Agreement to purchase ... iris authentication market leader EyeLock through an acquiring ... have a controlling interest in the acquiring entity. ... completion of due diligence.  Expanding on its existing ...
(Date:8/12/2015)... 12, 2015   MedNet Solutions , an innovative ... of clinical research, is proud to announce that ... SaaS-based eClinical technology platform, has led the way to ... quarters of 2015.   Q2 2015 and Q1 2015 ... by contract value sold in the company,s 15 year ...
(Date:8/11/2015)... Today, ZUK announced its Android smartphone Z1, featuring FPC,s touch ... 2015 that relate to sales of FPC1155 for this smartphone model ... for 2015. Jörgen Lantto, CEO of FPC, comments: " ... manufacturer in China and we are proud ... for Z1 , its first ...
Breaking Biology News(10 mins):VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5MedNet Solutions Experiences Explosive Corporate Growth 2FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2
... Rochelle, NY, September 1, 2010Biopharmaceutical firms and ... steps toward creating greener working environments and ... Engineering & Biotechnology News (GEN). This ... series of presentations and panel discussions that ...
... Biophysicists in Bochum have discovered a diode for protons: ... flow of electric current, the "proton diode" ensures that ... one direction. Water molecules play an important role here ... by Prof. Dr. Klaus Gerwert (Chair of Biophysics at ...
... reintroduction of wolves to Yellowstone National Park in 1995 is helping ... elk hungry for winter food had a different idea. They did ... of fear." According to a study set ... of the Ecological Society of America, the fear of wolf predation ...
Cached Biology News:GEN reports on the greening of the life sciences 2Bochum's researchers discover proton diode 2Are wolves saving Yellowstone's aspen trees from elk? 2Are wolves saving Yellowstone's aspen trees from elk? 3
(Date:8/27/2015)... 27, 2015 In response to recent ... and The US Postal Service to no longer ... ,select agents, by the CDC, Marken reaffirmed today ... sensitive shipments. Marken uses its flexible ... and certified personnel to ensure the safe and ...
(Date:8/26/2015)...  Roka Bioscience, Inc. (NASDAQ: ROKA ), a ... for the detection of foodborne pathogens, today announced that ... & Company Emerging Growth Conference on September 2 at ... New York Marriott Marquis. A live ... investor relations section of Roka Bioscience,s website at ...
(Date:8/26/2015)... GERMANTOWN, Md. , Aug. 26, 2015 ... synthetic biology, announced today the closing of its previously ... in full by the underwriters of their option to ... the public offering price of $41.00 per share.  The ... of shares of common stock sold by Intrexon to ...
(Date:8/26/2015)... 26, 2015 Despite recent ... the optimism in biotech,s forecast is the recent ... sciences advancements.  Active biotechnology & healthcare companies with ... (OTCQB: PBIO), Sequenom, Inc. (NASDAQ: SQNM ), ... Pharmaceutical Corp. (NASDAQ: RPTP ) and EnteroMedics ...
Breaking Biology Technology:Marken Ensures Safe Transportation Of Select Agents And Toxins 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 4New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 2New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 3New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 4New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 5New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 6New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 7
... ... about fast, new treatment program for FIV and FELV , ... New York, N.Y. (PRWEB) November 4, 2009 -- IMULAN BioTherapeutics, LLC ... fast way to get LTCI for feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV). ...
... ... To Target Tissues Affected by Osteoarthritis. Physics and Biology are Natural Partners in the ... ... medical device, the MyPhield Arthritis Therapy Cushion that naturally relieves osteoarthritis without causing unwanted ...
... Nov. 3 VIVUS, Inc. (Nasdaq: VVUS ... of novel therapeutic products, today reported its highlights and financial ... , Third Quarter Highlights , In ... two final, phase 3 pivotal 56-week studies, EQUIP (OB-302) and ...
Cached Biology Technology:New Program Developed in the Fight Against Feline Aids 2New Technology Now Available In Canada For Osteoarthritis 2VIVUS Reports Third Quarter 2009 Highlights and Financial Results 2VIVUS Reports Third Quarter 2009 Highlights and Financial Results 3VIVUS Reports Third Quarter 2009 Highlights and Financial Results 4VIVUS Reports Third Quarter 2009 Highlights and Financial Results 5VIVUS Reports Third Quarter 2009 Highlights and Financial Results 6VIVUS Reports Third Quarter 2009 Highlights and Financial Results 7VIVUS Reports Third Quarter 2009 Highlights and Financial Results 8
... HybriCycler Hybridization Oven with circular clear acrylic ... tubes. HC-3000 HybriCycler Oven features microprocessor operation ... feet balance the unit., Carousel rotates ... carousel is ,easily removable , Bottle ...
... The KingFisher magnetic particle based purification ... and DNA/RNA from any sample. They offer ... family comprises three systems- KingFisher, KingFisher mL ... 20 - 1000 l. Each system consists ...
... is specifically engineered for efficient drying down ... a glass cover and a post-trap with ... odor-free processing of samples in ammonium hydroxide., ... Oligos , Comes ...
... Thermo Savant SpeedVac™ Concentrators set the standard ... series SC210A SpeedVac with large chamber uses a ... dry multiple samples in a single run. , ... Rotor Chamber for long lasting chemical compatibility ...
Biology Products: