Navigation Links
Some immune cells defend only 1 organ
Date:4/17/2014

Scientists have uncovered a new way the immune system may fight cancers and viral infections. The finding could aid efforts to use immune cells to treat illness.

The research, in mice, suggests that some organs have the immunological equivalent of "neighborhood police" specialized squads of defenders that patrol only one area, a single organ, instead of an entire city, the body.

Scientists at Washington University School of Medicine in St. Louis have shown that the liver, skin and uterus each has dedicated immune cells, which they call tissue-resident natural killer cells. Other organs may have similar arrangements.

Their study, published in eLife, disproves the long-held assumption that all natural killer cells roam the body to provide the first line of defense against cancers and viruses.

"If, for example, we can use specialized medications to activate only these organ-specific cells, they could provide powerful and selective weapons against infections and tumors in the organs where they reside," said senior investigator Wayne M. Yokoyama, MD, the Sam and Audrey Loew Levin Professor of Medicine. "Cells that only defend one organ may be much better equipped than the roaming immune cells to mount an attack and limit collateral damage to healthy tissue."

Scientists have thought that mature natural killer cells circulate through the body looking for viruses and cancers. When these immune cells identify a threat, they attack. Scientists also thought that natural killer cells that stayed in the liver instead of circulating were immature or inactive and eventually would become like other natural killer cells, leaving the liver and moving through the body.

In the new study, lead author Dorothy K. Sojka, PhD, a postdoctoral research fellow in Yokoyama's laboratory, showed that some natural killer cells never leave the liver. She identified additional tissue-resident natural killer cells in the skin and uter
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. New method isolates immune cells for researchers to study how they ward off oral diseases
2. Sensitive balance in the immune system
3. La Jolla Institute discovers new mechanism for unleashing immune system against cancer
4. Immune cell defenders could beat invading bacteria
5. Newly discovered molecule may offer hope for immune disorders and runaway inflammation
6. IRCM researchers uncover a new function for an important player in the immune response
7. Study finds that fast-moving cells in the human immune system walk in a stepwise manner
8. An inventive new way to profile immune cells in blood
9. Scientists learn how pathogens hack our immune systems to go undetected
10. Study in mice raises question: Could PTSD involve immune response to stress?
11. Vitamin A used in acne medicines may help autoimmune and transplant patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the leading ... the launch of its new website design. "When ... its infancy", says Peter O,Neill , founder and CEO ... the industry needs involvement from the key players on a ...
(Date:1/22/2015)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a biometric authentication ... success of the Wocket™ smart wallet at CES 2015 in ... as one of the "11 Hot Products at CES" in a review ... So Far" by Newseveryday.com and "The top 10 gadgets from CES 2015" ...
(Date:1/22/2015)... Inc. , a market leader of iris-based identity authentication solutions, ... the new role of Senior Vice President of Mobile and ... platforms and wearable solutions for EyeLock,s technologies. Gerber brings more ... industry to his role at EyeLock, with expertise in human ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2
... Research Institute (IDIBELL) at the University of Barcelona ... IDPN nitrile causes neurological syndromes similar to those ... neuromuscular degenerative disease. The study, led by Jordi ... and Applied Neurobiology journal. Nitriles, chemical ...
... of the Japanese tree frog have learnt not to use ... can distinguish between them. Scientists at the Polytechnic University of ... an algorithm that assigns colours to network nodes an ... How can network nodes be coloured with the least ...
... the corner and it,s time to dust off the garden tables ... shade too long is often covered with a slimy film of ... to remove. Scientists are now hoping that they can solve this ... make the garden chair and adding a little bit of sunlight. ...
Cached Biology News:Poisoning from industrial compounds can cause similar effects to ALS 2Frog calls inspire a new algorithm for wireless networks 2Cleaning with sunlight 2
(Date:1/22/2015)... | RBJ today announces the firm brokered a long-term lease ... leading biopharmaceutical company, at Two Ledgemont Center in ... , president, and Brian Cohen , senior vice president, ... at 95 Hayden Ave. Photo - http://photos.prnewswire.com/prnh/20150122/170765 ...
(Date:1/22/2015)... BOSTON , Jan. 22, 2015  Transwestern | RBJ today ... feet of office space for Shire a leading biopharmaceutical company, ... . Transwestern | RBJ,s Robert Richards , president, and ... the lease for the entire five-floor building at 95 Hayden ...
(Date:1/22/2015)... 2015 The laboratory information management systems ... a number of technological advancements due to factors such ... need to integrate healthcare systems, and increasing government support ... system integration. Key players in the market focus on ...
(Date:1/22/2015)... Rootstown, OH (PRWEB) January 22, 2015 Crystal ... announced today that it has received AOAC-PTM Certifications for the ... O111, O121, and O145; collectively referred to as STEC or ... at 1 colony forming unit (cfu) per 325 g of ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
... Some of the first data from a new orbiting infrared ... analogy galaxies in general - is making new stars at ... findings from NASA's Spitzer Space Telescope were announced today (May ... a University of Wisconsin-Madison astronomer and the leader of a ...
... for 10 years in tax credits , ,MADISON ... Wisconsin was discussed at an economic development breakfast panel ... Business Development Center at the MG&E Innovation Center. A ... and private sector, discussed the implications of new tax-credit ...
... Formulatrix Inc. and Bruker AXS have ... incubation and imaging products. , ,Crystal Farm, developed by ... International , is an integrated product for incubation and ... design drugs. The system will now work with Formulatrixs ...
Cached Biology Technology:Milky Way churning out new stars at a furious pace 2Milky Way churning out new stars at a furious pace 3The impact of ACT 255 on the future of high-tech investment in Wisconsin 2Protein-crystal companies join forces for better imaging process 2
... is a flexible, fully automated microplate strip washer ... its fully automated microplate strip washing capability, the ... ease of operation. , Features ... manifolds of 8, 12 or 16 channels, crosswise ...
... Model 1575 immunowash microplate washer 100-240 V, ... have flat-, U-, or V-bottom wells. The ... and vertical needle positions to an accuracy ... aspiration, and overflow washing. It can store ...
... MULTI-FUN Incubator is a compact benchtop ... a microprocessor controller with a large ... and agitation speed. Air circulation inside ... incubator. Temperature can be easily calibrated ...
... a compact benchtop and stackable multi-function ... with a large display screen to ... Air circulation inside to evenly distribute ... be easily calibrated from the microprocessor ...
Biology Products: