"It is, therefore, difficult to predict the clinical outcomes of kidney trasplantation based on the results of islet isolation," the authors concluded.
Contact: Michihiro Maruyama, Department of Surgery, Chiba-east National Hospital, 673 Nitona, Chuo ku, Chiba City, Japan 2608712.
Tel. +81 43 261 5171
Fax. + 81 43 264 3269
Citation: Maruyama, M.; Kenmochi, T.; Saigo, K.; Naotake, A.; Iwashita, C.; Otsuki, K.; Ito, T. Results of islet isolation and their relationship to the clinical outcome of kidney transplantation in cases where both grafts are harvested from the same non-heart-beating donor. Cell Transplant. 21(2/3):559-563; 2012.
Adverse events in islet transplantationWhile noting that "islet transplantation is one of the most promising therapies for unstable type 1 diabetes," researchers from the Baylor Research Institute report on the nature and severity of adverse effects nine patients encountered after a combined total of 17 islet transplants.
"The results of islet transplantation need to further improve to justify disadvantages," said study author Dr. Shinichi Matsumoto of the Baylor Research Institute Islet cell Laboratory.
According to the researchers, 16 severe adverse events (SAEs) and 12 less severe adverse events (AEs) occurred within the first year after transplantation. The grade three SAEs included elevated liver enzymes, hemorrhage, infection and renal dysfunction. The case of neutropenia was a grade four. Twelve of the 16 SAEs were likely related to the transplant protocols, they said, while five AEs were judged to be related to infusion procedures as they occurred within 10 days of islet infusion. Seven events occurring after 50 days were related to immunosuppresive therapy.
"Because more than half of t
|Contact: David Eve|
Cell Transplantation Center of Excellence for Aging and Brain Repair