Citation: Noguchi, H.; Naziruddin, B.; Jackson, A.; Shimoda, M.; Ikemoto, T.; Fujita, Y.; Chujo, D.; Takita, M.; Peng, H.; Sugimoto, K.; Itoh, T.; Kobayashi, N.; Onaca, N.; Levy, M. F.; Matsumoto, S. Fresh islets are more effective for islet transplantation than cultured islets. Cell Transplant. 21(2/3):517-523; 2012.
Comparing success of islet cells and kidneys both retrieved from non-heart-beating donors
When researchers in Japan compared the outcomes of islets isolated from non-heart-beating donors (NHBDs) with the patient outcomes of kidney transplantations using the kidneys retrieved from the same NHBDs, they found that isolated islets were more severely affected by the poor conditions of the deceased donors than were the kidneys transplanted from the same NHBDs.
"Grafts from non-heart-beating donors are used because of the limited availability of heart-beating, brain-dead donors," said study lead author Dr. Michihiro Maruyama of the Chiba-East National Hospital in Chiba City, Japan. "This study sought to determine whether the results of islet isolations were correlated with the clinical outcomes of kidney transplantations in cases where both grafts were harvested from the same NHBD."
When the authors cited the poor condition of the NHBDs, they also noted that, in Japan, islets are usually not harvested from heart-beating, brain-dead donors, so NHBD are the only source for islets.
They reported that, in general, patients receiving kidneys from NHBDs require prolonged hemodialysis. Their study showed that "good results of islet isolation predicted good clinical outcomes for kidney transplantation where the kidneys and pancreas were harvested from the same donor."
However, the results of islet isolation and outcomes of kidney transplantation were "discrepant."
The authors concluded that the results of islet isolation were more severely affected by the "m
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Cell Transplantation Center of Excellence for Aging and Brain Repair