Navigation Links
Some cancer drugs may block cellular 'cross talk' but not kill cancer cells
Date:12/22/2010

AURORA, Colo. (Dec. 22, 2010)A class of drugs thought to kill cancer cells may in fact block "cross talk" between the cancer cell and normal immune cells, resulting in reduced cancer growth and spreada discovery that could significantly alter the way cancer drugs are evaluated in the future.

Researchers at the University of Colorado Cancer Center demonstrated the discovery in bladder cancer, the fifth most common cancer in the United States. Bladder cancer will kill about 14,000 Americans this year, most of whom will die as a result of the disease's spread to other organs in a process called metastasis.

The scientists showed that endothelin-A receptor antagonist drugs are only effective at blocking the start of cancer spread to other organs, not treating large, established primary-or distant-site tumors. The study was published online Dec. 22, 2010, in the Journal of Clinical Investigation.

"We discovered that these drugs block the 'tumor host interactions' found at sites of metastasis, which is what reduces tumor growth at these sites," said lead author Dan Theodorescu, MD, PhD, director of the University of Colorado Cancer Center and professor of surgery and pharmacology at the University of Colorado School of Medicine. "However, unless the drugs are used early, they have minimal or no effect."

Endothelin-A receptor antagonist drugs block the action of a protein called endothelin 1 [ET-1], thought to be involved in stimulating cancer cell growth and spread. Theodorescu's lab discovered that ET-1 attracts immune cells called macrophages to cancer cells lodged in the lungs. The macrophages start making factors that stimulate the cancer cells in the lungs to growcalled metastatic colonizationwhich significantly decreases the patient's chance of survival.

In the past decade, two endothelin-A receptor antagonist drugsAbbott's atrasentan and AstraZeneca's zibotentanhave had difficulties in large phase 3 clinical
'/>"/>

Contact: Caitlin Jenney
caitlin.jenney@ucdenver.edu
303-315-6376
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover genetic predisposition for breast, kidney cancers
2. Damon Runyon Cancer Research Foundation awards breakthrough scientists
3. Key information about breast cancer risk and development is found in junk DNA
4. Scientists discover powerful biomarker panel for the early detection of breast cancer
5. Blocking the critical structure that lets cancer cells move -- their feet
6. Missing molecules hold promise of therapy for pancreatic cancer
7. Scientists identify how virus triggers cervical and mouth cancer
8. A protein called cFLIP makes tumor cells in breast cancer resistant to treatments
9. Study: Osteoporosis drug reduces bone loss, tumor size in oral cancer
10. Ovarian cancer screening saves few lives
11. UCR scientists identify pomegranate juice components that could stop cancer from spreading
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... The increased risk of kidney injury related to the ... the mass of HES molecules, according to a report ... the International Anesthesia Research Society (IARS). , The "total ... HES on cultured human renal proximal tubule cells (PTCs), ... colleagues of University Hospital Wrzburg, Austria. Other factorssuch ...
(Date:7/11/2014)... Research and Markets has announced the addition ... Analysis Size Share Growth Trends and Forecast to 2019" ... http://photos.prnewswire.com/prnh/20130307/600769 The rising number of ... high level security in both private and public sector. ... and passwords, tokens etc. are vulnerable to attacks. Biometrics ...
(Date:7/10/2014)... , June 27, 2014  Pomerantz LLP has ... Inc. ("Provectus" or the "Company")(NYSE-MKT: PVCT) and certain ... United States District Court, Middle District of ... behalf of a class consisting of all persons ... securities between December 17, 2013 and May 22, ...
Breaking Biology News(10 mins):In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3
... Scientists found that in 14 independent studies, the yields ... other biofuel feedstocks, such as corn, soybean, sorghum, and ... not yet been evaluated exist. According to bioenergy ... a low risk of unintended land use change. Biomass ...
... have developed a novel system for delivery of growth ... diabetic foot ulcers. In their work published in ... of Sciences , the team from the MGH Center ... keratinocyte growth factor (KGF), a protein known to play ...
... year,s Deepwater Horizon oil spill, nearly 800,000 gallons of chemical ... coming out of the wellhead nearly one mile deep in ... assess how well the strategy worked at breaking up oil ... and her colleagues report that a major component of the ...
Cached Biology News:Growth-factor-containing nanoparticles accelerate healing of chronic wounds 2First study of dispersants in Gulf spill suggests a prolonged deepwater fate 2First study of dispersants in Gulf spill suggests a prolonged deepwater fate 3First study of dispersants in Gulf spill suggests a prolonged deepwater fate 4
(Date:7/10/2014)... OAKS, Calif., July 10, 2014   Ceres, Inc ... and seed company, announced today financial results for the ... update on its business. Ceres reported that ... in product performance this growing season in Brazil, which ... affected the company,s sorghum evaluation areas for part of ...
(Date:7/10/2014)... Using microscopic polymer light resonators that expand in ... Quantum Photonics Laboratory have developed new optical sensors ... Optical sensors are ideal for detecting trace gas ... lightweight nature, and immunity to electromagnetic interference. , ... before, the MIT team conceived an extremely sensitive, ...
(Date:7/10/2014)... Columbia researchers have observed the fractional quantum Hall effect ... of matter can be tuned by an electric field. ... occur when electrons confined to thin sheets are exposed ... collective behavior where thousands of individual electrons behave as ... this effect is well established, many details of this ...
(Date:7/10/2014)... shelled out for crude 3-D glasses, polarized glasses, ... These basic devices, used to trick the brain ... be rendered obsolete with the introduction of new ... , TAU doctoral students Yuval Yifat, Michal Eitan, ... based on nanoantennas that could be used for ...
Breaking Biology Technology:Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Swell new sensors 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3
... St. Joseph,s Hospital and Medical Center and the University ... agreement to create the Valley Fever Center based at the ... who has more than 30 years of experience in treating ... of Excellence in Tucson in 1996. The center ...
... At the Heart Failure Society of America,s 15th Annual ... System, announced that B-type natriuretic peptide (BNP) may have ... signs of decompensation in advance of acute presentations.   ... and sponsored by Alere Inc., is the first of ...
... Biotherapeutics (OTC.BB: NWBO) (NORTHWEST BIO) today announced that ... Cancer Immunotherapy: A Long-Awaited Reality Conference on Thursday, ... Medicine in New York City.  The single-day conference ... stakeholders to engage in discussions, exchange information, and ...
Cached Biology Technology:St. Joseph's Hospital, University of Arizona Create Valley Fever Center in Phoenix 2HABIT Study Highlights Home BNP Testing May Allow for Earlier Interventions and Better Management of Heart Failure Patient 2HABIT Study Highlights Home BNP Testing May Allow for Earlier Interventions and Better Management of Heart Failure Patient 3NORTHWEST BIO Will Present at the Second Annual "Cancer Immunotherapy: A Long Awaited Reality Conference" at the New York Academy of Medicine, October 6, 2011 2NORTHWEST BIO Will Present at the Second Annual "Cancer Immunotherapy: A Long Awaited Reality Conference" at the New York Academy of Medicine, October 6, 2011 3NORTHWEST BIO Will Present at the Second Annual "Cancer Immunotherapy: A Long Awaited Reality Conference" at the New York Academy of Medicine, October 6, 2011 4
... an 18 amino acid synthetic peptide whose sequence corresponds to residues ... is (amino to carboxy terminus): M(1) - A - S - ... - S - P - R - D - A - ... may be used for neutralization and control experiments with the polyclonal ...
... Bisulfite Kit enables complete conversion of ... than 6 hours. The highly sensitive ... DNA degradation and a spin-column-based purification ... and reliable results for all downstream ...
... from high throughput synthesis are new and unique ... These products provide a large number (from hundreds ... in a microtube as a mixture or in ... sequence. This is a custom product so RNA ...
... is a fixative useful for routine procedures. ... is stable and will decalcify small bone ... can be stained successfully with most stains, ... stabilizes red blood cell membranes and cosinophil ...
Biology Products: