Navigation Links
Some brain tumors may be mediated by tiny filament on cells
Date:8/23/2009

in a subset of human tumors, but absent in others. The presence and absence correlated with the cell-signaling pathways that were activated in the tumors. This suggests, the researchers say, that, as in mice, some tumors in humans need to remove the primary cilia to grow, while other require its presence to grow.

The explanation, says the lead investigator of the medulloblastoma study, Young-Goo Han, PhD, a postdoctoral fellow in the Alvarez-Buylla lab, has to do, in part, with the way in which the primary cilium is structured and functions.

Unlike their beating cousins, known as motile cilia, or flagella -- which swish protozoa through pond water and undulate in the airways -- primary cilia are generally immobile, and function as cellular antennae. They receive signals from other cells, allowing for their transmission, in a process known as signal transduction, down a pathway of signaling proteins -- some of which are located precisely in the cilia -- into the cytoplasm, ending at the cell's nucleus, where the signals' commands are issued.

One of the key signaling molecules in development is a secreted lipoprotein known as Hedgehog, which regulates tissue patterning, cell proliferation, and many other biological processes. Recently, scientists have discovered that Hedgehog signaling functions through the primary cilium. As Hedgehog approaches a target cell, it binds to its receptor, Patched1 (Ptch1), on the cilia, opening the gate for another protein, known as Smoothened (Smo) to enter into the cilium. There, Smo, an essential activator of the Hedgehog pathway, initiates the biochemical cascade that leads to the activation of a "downstream" protein known as Gli2, which in part communicates the Hedgehog signal to the cell's nucleus.

Aberrant Hedgehog signaling is well known to lead to human cancers, including basal cell carcinoma and medulloblastoma. However, it was not known if the cilium, itself, played a role in the development of cancer
'/>"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Mouse brain rewires its neural circuits to recuperate from damaged neural function after stroke
2. Doing what the brain does -- how computers learn to listen
3. Brain innately separates living and non-living objects for processing
4. A window into the brain
5. Hebrew U. researchers shed light on the brain mechanism responsible for processing of speech
6. STAT3 gene regulates cancer stem cells in brain cancer
7. Abnormal brain circuits may prevent movement disorder
8. Brain difference in psychopaths identified
9. Holding breath for several minutes elevates marker for brain damage
10. A crystal ball for brain cancer?
11. Experimental treatment halts hypoxic-ischemic brain injury in newborns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... One of Australia,s leading coral reef ecologists fears that ... for ecosystem survival that we once thought. , In ... the ARC Centre of Excellence for Coral Reef Studies ... the most important species within reef ecosystems. , In ... are vital jobs that keep the ecosystem safe and ...
(Date:9/15/2014)... professor in the Department of Science and Technology in ... Sciences at Virginia Tech, has won a 2014 National ... the prospects and problems of creating a global nuclear ... Fukushima I Nuclear Power Plant in March 2011 was ... nuclear emergencies, Schmid said. Three of the plant,s six ...
(Date:9/15/2014)... of the cheetah: The big predator is the fastest land ... just a few seconds. As it ramps up to top ... it reaches a full gallop. , Now MIT researchers have ... a robotic cheetah a sleek, four-legged assemblage of gears, ... its feline counterpart. The team recently took the robot for ...
Breaking Biology News(10 mins):Specialized species critical for reefs 2'Nuclear disasters don't respect national boundaries' 2Run, cheetah, run 2Run, cheetah, run 3
... of climate change on the microbial communities of two ... in Alaska, a University of Oklahoma research group has ... According to Jizhong Zhou, OU professor of botany ... Genomics, the results of these studies could potentially contribute ...
... WORCESTER, Mass. Researchers at the University of Massachusetts Medical ... which is implicated in 20 percent of inherited cases of ... a part in sporadic forms of the disease. Discovery of ... edition of Nature Neuroscience . While the SOD1 ...
... 18 October 2010, Singapore A total of 15 world ... in their respective fields at the 6th Decade of the ... 20 October 2010. Jointly organised by A*STAR,s Institute of ... (DRTech) and NUS,s Temasek Laboratories, it is the first such ...
Cached Biology News:UMMS researchers identify protein associated with sporadic ALS 2UMMS researchers identify protein associated with sporadic ALS 3Singapore hosts first 'Decade of the Mind' conference in Asia 2Singapore hosts first 'Decade of the Mind' conference in Asia 3
(Date:9/15/2014)... Hydro Dynamics, Inc. (HDI) of Rome, ... will be partnering with Proteaf Technologies (Proteaf) of ... implementing its Shock Wave Power Reactor (SPR) cavitation ... flow chemistry through process intensification has been widely ... for decades. The continuous chemistry has been ...
(Date:9/14/2014)... wide variety of ways, including by modifying the protein ... another form and perform no or even the "wrong" ... serious diseases such as Alzheimer,s, Parkinson,s or cystic fibrosis. ... "infect" other molecules of the same type and congregate ... can damage cells and tissues and make people ill. ...
(Date:9/13/2014)... Boehringer Laboratories Inc., with a forty year history ... successful broadcast of a live surgery by St. Luke’s ... FAMBS, and Maher El Chaar, MD, FACS, FAMBS, using ... This sleeve gastrectomy surgery was performed and broadcast live ... surgeons from around the world during the 5th International ...
(Date:9/12/2014)... 2014   Arthur Kay , the 23-year-old British ... Postcode Lottery Green Challenge 2014. The jury, chaired by ... USD) at the final in Amsterdam ... Kay,s company uses a patented process to upcycle ... and biomass pellets, used for powering buildings and transport ...
Breaking Biology Technology:Hydro Dynamics Partners with the Continuous Flow Chemistry Experts of Proteaf Technologies 2Measuring modified protein structures 2Measuring modified protein structures 3Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 3
... is,strengthening its customer-focused biomarker services portfolio to,pharmaceutical, ... Xie will lead those efforts as Battelle,s ... a suite of biomarker services, including biomarker,discovery, ... clients,better define molecular mechanisms of diseases, toxicity, ...
... against management - with six million, votes revoked ... change rules, TORONTO, June 25 /PRNewswire/ - The ... be in court today and will seek a,declaration that ... Meeting,was illegally held and will request that a proper ...
... probiotic ingredient, GanedenBC30, to power new raisin bran probiotic muffins. ... ... Main Street Gourmet, one of the fastest growing manufacturers of gourmet ... muffin fortified with the high-survivability probiotic, GanedenBC30 (Bacillus coagulans ...
Cached Biology Technology:Battelle Selects Xie to Develop Biomarker Services 2Main Street Gourmet Launches New Probiotic Muffins 2Main Street Gourmet Launches New Probiotic Muffins 3
... Clinical is Tecans open platform for clinical ... safety and performance in the clinical diagnostic ... by flexible barcode reading and sample traceability ... the system complies with the IVD-Directive* established ...
... The new TC-412 thermal cycler, flexible on your ... is a high performance, high sample throughput instrument ... , Flexible block format: The truly user-friendly ... exchanged in a matter of seconds without the ...
Preparation Note: Prepared by method of Wimmer, E., et al., Biochemistry, 7, 2623 (1968). Quality Clarifier: Acceptor Activity: approx. 1000 picomoles phenylalanine per A 260 unit (not determined b...
... which is based on a new flow-through technology, ... in situ hybridization of tissues on microscope slide ... study of gene expression, in situ hybridization (ISH) ... can be used to validate and confirm results ...
Biology Products: