Navigation Links
Some brain tumors may be mediated by tiny filament on cells
Date:8/23/2009

in a subset of human tumors, but absent in others. The presence and absence correlated with the cell-signaling pathways that were activated in the tumors. This suggests, the researchers say, that, as in mice, some tumors in humans need to remove the primary cilia to grow, while other require its presence to grow.

The explanation, says the lead investigator of the medulloblastoma study, Young-Goo Han, PhD, a postdoctoral fellow in the Alvarez-Buylla lab, has to do, in part, with the way in which the primary cilium is structured and functions.

Unlike their beating cousins, known as motile cilia, or flagella -- which swish protozoa through pond water and undulate in the airways -- primary cilia are generally immobile, and function as cellular antennae. They receive signals from other cells, allowing for their transmission, in a process known as signal transduction, down a pathway of signaling proteins -- some of which are located precisely in the cilia -- into the cytoplasm, ending at the cell's nucleus, where the signals' commands are issued.

One of the key signaling molecules in development is a secreted lipoprotein known as Hedgehog, which regulates tissue patterning, cell proliferation, and many other biological processes. Recently, scientists have discovered that Hedgehog signaling functions through the primary cilium. As Hedgehog approaches a target cell, it binds to its receptor, Patched1 (Ptch1), on the cilia, opening the gate for another protein, known as Smoothened (Smo) to enter into the cilium. There, Smo, an essential activator of the Hedgehog pathway, initiates the biochemical cascade that leads to the activation of a "downstream" protein known as Gli2, which in part communicates the Hedgehog signal to the cell's nucleus.

Aberrant Hedgehog signaling is well known to lead to human cancers, including basal cell carcinoma and medulloblastoma. However, it was not known if the cilium, itself, played a role in the development of cancer
'/>"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Mouse brain rewires its neural circuits to recuperate from damaged neural function after stroke
2. Doing what the brain does -- how computers learn to listen
3. Brain innately separates living and non-living objects for processing
4. A window into the brain
5. Hebrew U. researchers shed light on the brain mechanism responsible for processing of speech
6. STAT3 gene regulates cancer stem cells in brain cancer
7. Abnormal brain circuits may prevent movement disorder
8. Brain difference in psychopaths identified
9. Holding breath for several minutes elevates marker for brain damage
10. A crystal ball for brain cancer?
11. Experimental treatment halts hypoxic-ischemic brain injury in newborns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... 2015 Research and ... the "Body-Worn Temperature Sensors Market - Global ... 2014 - 2020" report to their offering. ... the global body-worn temperature sensors market. The global ... the basis of types, care setting, patient demographic, ...
(Date:6/23/2015)... PALM BEACH GARDENS, Fla. , June ... of multi-factor identity management and authentication solutions, today ... Altus strong, multi-factor authentication solution.  The ... ease of use of the DigitalPersona Altus ... and biometric reader compatibility. In ...
(Date:6/18/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... mobile commerce market announces that its Wocket® smart wallet will ... the Mark", scheduled to air on WABC Radio (am770) in ... . The broadcast air- time for the ... EST. NXT-ID, Inc.,s CEO Gino Pereira will be ...
Breaking Biology News(10 mins):Body-Worn Temperature Sensors Market - Global Industry Analysis 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3
... derived from honeybee hives arrests the growth of prostate cancer ... from researchers at the University of Chicago Medicine. Caffeic ... honeybee hive propolis, the resin used by bees to patch ... as a natural remedy for conditions ranging from sore throats ...
... three or more feet in diameter accounted for nearly ... site, yet represented only one percent of the trees ... fir, sugar pine and incense cedars per acre at ... carbon dioxide into plant tissue and sequestering that carbon ...
... of the most of the spectacular traits in nature: the ... on walruses and antlers on moose. Sexual conflict the ... to be a particularly potent force in driving the evolution ... genetic processes responsible for producing such traits are not well ...
Cached Biology News:Beehive extract shows potential as prostate cancer treatment 2Beehive extract shows potential as prostate cancer treatment 3Handful of heavyweight trees per acre are forest champs 2Handful of heavyweight trees per acre are forest champs 3Biologists turn back the clock to understand evolution of sex differences 2
(Date:7/7/2015)... 2015  SME,s Advanced Manufacturing Media is proud to ... issue, celebrating young men and women who have demonstrated ... issue of Manufacturing Engineering magazine ... their accomplishments. Among the standouts: Christopher Tyler , ... optimizing the topology of flapping wing vehicles; Kathryn ...
(Date:7/7/2015)... ... ... The global aptamers market is expected to reach $244.93 ... 17.89% between 2015 and 2020. The aptamer type segments included in this report ... is segmented into diagnostics, therapeutics development, R&D, and other applications. Diagnostics applications will ...
(Date:7/7/2015)... ... July 07, 2015 , ... Currently deployed within ... was developed to solve many of the complex logistical and data management challenges ... multiple clinical sites and/or remote data coordination centers. , CentrePoint drastically reduces ...
(Date:7/6/2015)... ... July 06, 2015 , ... ... (WPI), offers new insights into how virulent fungi adapt through genetic modifications to ... how that battle leaves them temporarily weakened. These insights may provide clues to ...
Breaking Biology Technology:SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 2SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 3SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 4SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 5Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 2Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 3Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 4Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 5ActiGraph Launches CentrePoint Cloud-based Study Management Software Platform 2ActiGraph Launches CentrePoint Cloud-based Study Management Software Platform 3Worcester Polytechnic Institute Co-directs Study That Provides New Insights into the Genetics of Drug-Resistant Fungal Infections 2Worcester Polytechnic Institute Co-directs Study That Provides New Insights into the Genetics of Drug-Resistant Fungal Infections 3Worcester Polytechnic Institute Co-directs Study That Provides New Insights into the Genetics of Drug-Resistant Fungal Infections 4
... Wisconsin Health Information Exchange has been awarded an ... Wisconsin for calendar year 2006. , ,The funds ... 501c3 entity, to develop its governance structure and administrative ... health events through sharp increases in emergency room traffic, ...
... - Metavante Corp ., the banking and payments ... is in the final stages of acquiring VICOR, ... processing software. , ,VICOR is being pursued, in part, ... to its client financial institutions so they can address ...
... Wis. – Prodesse Inc. , a biotechnology ... for the testing of infectious diseases, has entered into ... , the Basel, Switzerland-based pharmaceutical firm. , ,Under the ... the right to include Roche enzymes in its products. ...
Cached Biology Technology:WHIE receives state eHealth Initiative contract 2
... a base medium for preparation of minimal and ... but does not contain amino acids. Both bulk ... pouch contains reagents to prepare 500 ml of ... of 10X YNB for S. cerevisiae media. Store ...
... Progesterone Receptor (PR) Competitor Assay Kits ... novel progesterone receptor binding compounds using ... utilizes a fusion of glutathione transferase ... human progesterone receptor [PR-LBD(GST)] and a ...
... Protein G bind specifically to Fc regions ... Protein G conjugates are commonly used as ... immunoglobulin subtypes from serum, hybridoma ascites fluids, ... These reagents are also commonly used to ...
... the first instrument engineered to match the ... by thousands of research centers worldwide. It ... which are ideally suited for high-speed temperature ... extremely high surface-area-to-volume ratio. ,By combining glass ...
Biology Products: