Navigation Links
Some HDL, or 'good' cholesterol, may not protect against heart disease
Date:5/7/2012

Boston, MA A new study by Harvard School of Public Health (HSPH) researchers has found that a subclass of high-density lipoprotein (HDL) cholesterol, the so-called "good" cholesterol, may not protect against coronary heart disease (CHD) and in fact may be harmful.

This is the first study to show that a small protein, apolipoprotein C-III (apoC-III), that sometimes resides on the surface of HDL cholesterol may increase the risk of heart disease and that HDL cholesterol without this protein may be especially heart protective.

The study was published online in the Journal of the American Heart Association.

"This finding, if confirmed in ongoing studies, could lead to better evaluation of risk of heart disease in individuals and to more precise targeting of treatments to raise the protective HDL or lower the unfavorable HDL with apoC-III," said Frank Sacks, professor of cardiovascular disease prevention at HSPH and senior author of the study.

A high level of HDL cholesterol is strongly predictive of a low incidence of coronary heart disease (CHD). But trials of drugs that increase HDL cholesterol have not consistently shown decreases in CHD, leading to the hypothesis that HDL cholesterol may contain both protective and non-protective components.

ApoC-III, a proinflammatory protein, resides on the surface of some lipoproteinsboth HDL and low-density lipoproteins, or LDL ("bad") cholesterol. The researchers, led by Sacks and Majken Jensen, research associate in the Department of Nutrition at HSPH, examined whether the existence or absence of apoC-III on HDL cholesterol affected the "good" cholesterol's heart-protective qualities, and whether its existence could differentiate HDL cholesterol into two subclassesthose which protect against the risk of future heart disease and those which do not.

Blood samples collected in 1989 and 1990 from 32,826 women in the Brigham and Women's Hospital-based Nurses' Health S
'/>"/>

Contact: Todd Datz
tdatz@hsph.harvard.edu
617-432-8413
Harvard School of Public Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Ethical Adaptation to Climate Change envisions the good life in a harsher world
2. Light weights are just as good for building muscle, getting stronger, researchers find
3. Evidence shows that anti-depressants likely do more harm than good, researchers find
4. Study finds cancer-fighting goodness in cholesterol
5. Manatee hearing good enough to sense approaching motorboats
6. How good cholesterol turns bad
7. The good news about carbon storage in tropical vegetation
8. Good parents are predictable -- at least when it comes to corn
9. The biology of politics: Liberals roll with the good, conservatives confront the bad
10. Report answers questions about E. coli: The good, the bad and the deadly
11. Good preparation is key -- even for plant cells and symbiotic fungi
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... 2015 According to a ... (Hardware, Software, Services), by Applications (Surveillance (Airborne, Maritime, ... End-Users (Military & Defense & Commercial) - Global ... Market is expected to grow from $7252.0 Million ... a Compound Annual Growth Rate (CAGR) of 6.6%. ...
(Date:5/19/2015)... Sweden , May 18, 2015 ... fingerprint sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one ... from June until and including Q3 2015 and the sensors ... . Communicated order values for 2015 hereby amount to ... for Q1 2015 of 140 MSEK and a number of ...
(Date:5/14/2015)... , May 14, 2015 Research and Markets ... the "Fingerprint Sensors Market in Smart Mobile Devices ... report believes that 2014 was a watershed year for ... introduction of ,Apple Pay,. Apple gave fingerprint sensors a ... payment service. Fingerprint sensors are a must-have feature in ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2
... this release has been changed to 7 p.m. EST Sept. ... that the global distribution of macro- and microorganisms might be ... Evolutionary Biology, shows that some protozoa are globally dispersed, while ... fast-evolving DNA marker. The study also reveals that the biodiversity ...
... islet cells from pigs may be used in clinical ... diabetes. This key finding was the discovery ... Institute for Immunology & Transplantation at the University of ... in the prestigious scientific journal Nature Medicine in March ...
... at Childrens Hospital of Pittsburgh of UPMC have ... a vaccine against Chlamydia trachomatis, the most prevalent ... The researchers, led by Toni Darville, MD, chief ... Childrens, identified a plasmid-deficient strain of Chlamydia that, ...
Cached Biology News:DNA analysis shows true dispersal of protozoa 2Breakthrough research identifies how cells from pigs may cure diabetes 2Study by Pittsburgh researchers identifies possible vaccine target for chlamydia 2
(Date:6/2/2015)... Diego, Calif. (PRWEB) June 02, 2015 ... of build-to-order, independent blade-based and rackmount computing and ... today announced the launch of its high density ... the Cirrascale Slipstream™ RM1622D . The high ... processor E3-1200 v4 product family with Intel® Iris™ ...
(Date:6/2/2015)... --  BioClinica ® , Inc., a specialty clinical ... David Peters , an accomplished senior finance and accounting ... Financial Officer (CFO) and will be joining BioClinica on ... 25 years of financial and accounting experience with a ... knowledge in all areas of finance, accounting and business ...
(Date:6/2/2015)... , June 2, 2015 /PRNewswire/ -- China Cord Blood Corporation ... "our"), China,s leading provider of cord ... cell storage services, today announced that the Special Committee of ... Houlihan Lokey ( China ) Limited ... & Hamilton LLP as its United States ...
(Date:6/2/2015)... 2015 MGB Biopharma at ... problem  MGB Biopharma, a biopharmaceutical company ... address the major global problem of antibiotic resistance ... intravenous (IV) formulation of MGB-BP-3, designed for the treatment ... The intravenous formulation of MGB-BP-3 is currently ...
Breaking Biology Technology:Cirrascale® Announces Support for Intel® Xeon® Processor E3-1200 v4 Product Family; Launches Server Offering Optimized for Low Cost-per-Stream Transcoding Applications 2Cirrascale® Announces Support for Intel® Xeon® Processor E3-1200 v4 Product Family; Launches Server Offering Optimized for Low Cost-per-Stream Transcoding Applications 3BioClinica Names David Peters New Chief Financial Officer 2China Cord Blood Corporation's Special Committee Appoints Independent Financial Advisor and Legal Counsel to Evaluate Non-binding "Going Private" Proposal 2China Cord Blood Corporation's Special Committee Appoints Independent Financial Advisor and Legal Counsel to Evaluate Non-binding "Going Private" Proposal 3MGB Biopharma Succeeds in Developing an IV Formulation of MGB-BP-3 for the Treatment of Systemic Susceptible and Resistant Gram-Positive Hospital-Acquired Infections 2MGB Biopharma Succeeds in Developing an IV Formulation of MGB-BP-3 for the Treatment of Systemic Susceptible and Resistant Gram-Positive Hospital-Acquired Infections 3
... 28 Entest BioMedical, Inc., a newly formed wholly-owned ... Bulletin Board: BMSN) announced today the launch of its ... to focus on new stem cell research, including a ... traumatic brain injury (TBI) using autologous adipose-derived (fat) stem ...
... ("MedMira") (TSX Venture: MIR, NASDAQ: MMIRF ), ... solutions, announced today that VWR International, LLC (VWR) has ... Chester, Pennsylvania, VWR is a global laboratory supply and ... billion. , "The U.S. is an important market for ...
... Diagnostics scientists will present results of three studies revealing ... treatment of chronic myeloid leukemia (CML) and prostate cancer ... of Clinical Oncology (ASCO), scheduled for May 29 through ... DGX ) is the world,s leading provider ...
Cached Biology Technology:New Stem Cell Web Site to Focus on Traumatic Brain Injury, Spinal Cord Injury and Diabetes 2MedMira Strengthens North American Sales Channels, Adding VWR as Distributor for the United States 2Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting 2Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting 3Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting 4Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting 5
... cm, is used for vertical slab gel electrophoresis ... The cell is supplied without spacers and combs. ... gaskets, lower buffer chamber, lid with cables, 2 ... buffer dam, casting stand with gaskets, leveling bubble, ...
... PROTEAN II xi cell, 20 cm, is used ... and proteins in agarose gels. The cell is ... a central cooling core with gaskets, lower buffer ... plates, 4 sandwich clamps, upper buffer dam, casting ...
CleanCut agarose is used to prepare genomic DNA plugs for use in pulsed field gel electrophoresis (PFGE) applications. Supplied as a 12 ml solution of 2% agarose....
... minor groove-binding probe for DNA. Binds to ... to AT rich DNA), forming a stable ... than DAPI alone. DAPI is several times ... DNA in agarose gels. It may be ...
Biology Products: