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SomaLogic researchers describe revolutionary new approach to protein analysis and application to early diagnosis of lung cancer
Date:12/2/2010

SOMAmers are essentially small bits of DNA, current DNA measurement technologies like microarrays can be used to measure them and provide a readout of protein or biomarker types and concentrations in a fast and simple analysis. This powerful combination specific binding to individual proteins and DNA-based quantification allows the researchers to accurately detect and measure literally a thousand proteins in as little as a few drops of blood in a single experiment. The first PLoS One paper describes this breakthrough technology in detail, and demonstrates its power through application to samples from patients with chronic kidney disease, finding not only known markers of the disease but many previously unknown protein biomarkers.

Today, single protein biomarkers are the foundation of clinical diagnostics: but both normal and disease biology is far more complex than a single measurement can capture: We need to look at multiple biomarkers, or a signature of proteins, that is truly revealing about health and disease at that moment, said Steve Williams, Chief Medical Officer of SomaLogic. The SOMAmer technology empowers us for the first time to measure real biology in a clinically meaningful way.

In the second PLoS One paper, SomaLogic researchers and their collaborators at multiple sites describe the application of SOMAmers at large scale, uncovering a panel of biomarkers that announce the presence of lung cancer. Lung cancer is the leading cause of cancer deaths, mostly because it is detected under current technologies only at its latest stages. By applying SOMAmer technology to over 1300 clinical samples, the researchers rapidly identified a panel or signature of 12 proteins that together accurately reveal the presence of lung cancer in at-risk patients (e.g., long-term smokers). This finding is the basis for a new diagnostic test under development for clinical application in the next year.

By being able to detect lung cancer early, we fi
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Contact: Jeff Walker
jwalker@somalogic.com
303-625-9021
SomaLogic, Inc.
Source:Eurekalert

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