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Solving the riddle of nature's perfect spring
Date:3/1/2011

Scientists have unravelled the shape of the protein that gives human tissues their elastic properties in what could lead to the development of new synthetic elastic polymers.

University of Manchester researchers, working with colleagues in Australia and the United States, used state-of-the-art techniques to reveal the structure of tropoelastin, the main component of elastin.

Elastin allows tissues in humans and other mammals to stretch, for example when the lungs expand and contract for respiration or when arteries widen and narrow over the course of a billion heart beats.

The study, published in the science journal PNAS (March issue), revealed how evolution has triumphed where engineering has so far failed by generating a molecule with near-perfect elasticity that will last a lifetime.

"All mammals rely on elastin to provide their tissues with the ability to stretch and then return to their original shape," said researcher Dr Clair Baldock, from the University of Manchester's Wellcome Trust Centre for Cell Matrix Research. "This high level of physical performance demanded of elastin vastly exceeds and indeed outlasts all human-made elastics.

"It is the co-ordinated assembly of many tropoelastins into elastin that gives tissues their stretchy properties and this exquisite assembly helps to generate elastic tissues as diverse as artery, lung and skin.

"We discovered that tropoelastin is a curved, spring-like molecule with a 'foot' region to facilitate attachment to cells. Stretching and relaxing experiments showed that the molecule had the extraordinary capacity to extend to eight-times its initial length and can then return to its original shape with no loss of energy, making it a near-perfect spring."

She added: "Elastics are used in applications as diverse as clothing, vehicles, tissue engineering and even space travel, so understanding how the structure of tropoelastin creates its exceptional el
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Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

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