Navigation Links
Solving the puzzle of the BK ion channel
Date:6/23/2010

an answer, published in the June 24 issue of the journal Neuron.

It turns out that the mutation makes part of the channel more rigid, altering its dynamics in a way that makes it easier to toggle it open. This is the first time, says Cui, that protein dynamics have been implicated in the functioning of an ion channel.

Ion channels

Life itself depends on ion channels, the tiny pores in our cells that open on cue, letting charged atoms rush in or out. These influxes and effluxes create the electrical signals that make our eyes blink or our ribs expand to draw breath.

But because the channels are tiny and stuck in the greasy cell membrane, they are hard to study. Their existence wasn't even confirmed until the 1970s. Working out the structure and function of a single ion channel (there are more than 300 types) earned researchers a Nobel Prize as recently as 2003.

Nerve impulses are actually changes in the electrical potential across a nerve cell's membrane. The traveling wave of electrical excitation, known as an action potential, is orchestrated by the synchronized opening and closing of ion channels.

At rest, cells are slightly more negative (a matter of millivolts) inside than they are outside. An action potential starts when sodium channels open, allowing positively charged sodium atoms to rush into the cell, reversing the polarization of the membrane.

The sodium channels then automatically close and potassium channels open, repolarizing the membrane by allowing positively charged potassium ions to flood out of the cell.

What the BK channel does

One of the BK channel's functions is to allow a nerve to adapt to constant stimulation by becoming less responsive. This loss of sensitivity is what allows us, for example, to ignore the constant pressure of our clothing.

Ion channels are gated, or triggered, in a variety of ways. Voltage-gated channels respond to the vol
'/>"/>

Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Brains problem-solving function at work when we daydream
2. Bowman Global Change says public engagement critical to solving climate crisis
3. Fossils and layers: Solving the terrane puzzle of the North American cordillera
4. Solving an avian scourge could also provide benefits to human health
5. New tool for resolving fisheries conflicts
6. Magnetic snakes control fluids, gravity-defying droplets, and solving a dragonfly mystery
7. McGill team discovers a piece of the puzzle for individualized cancer therapy via gene silencing
8. Key piece of puzzle sheds light on function of ribosomes
9. CSHL scientists harness logic of Sudoku math puzzle to vastly enhance genome-sequencing capability
10. New piece found in the puzzle of epigenetics
11. Biologists devise unifying framework to explain evolutionary puzzles
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Solving the puzzle of the BK ion channel
(Date:2/5/2015)... , Jan. 28, 2015 Research and ... the addition of the "Global Biometrics Market ... Regions and Countries " report to their offering. ... Asia-Pacific is anticipated to ... 2015, owing to increasing government spending towards IT ...
(Date:1/22/2015)... , Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the leading ... the launch of its new website design. "When ... its infancy", says Peter O,Neill , founder and CEO ... the industry needs involvement from the key players on a ...
(Date:1/22/2015)... NXTD and NXTDW) a biometric authentication company focused on ... Wocket™ smart wallet at CES 2015 in Las Vegas ... the "11 Hot Products at CES" in a review published in Wired.com, ... Newseveryday.com and "The top 10 gadgets from CES 2015" by Danny ...
Breaking Biology News(10 mins):Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 3Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... Dr. William Phillips, an Office of Naval Research ... lecture at ONR,s spring distinguished lecture series May ... the Coolest Stuff," highlighted the importance of basic ... scientists. Among the attendees at Phillips, lecture ...
... . , It is the concentration of a few ... the early development of organisms. In the renowned journal ... Pia Aanstad of the University of Innsbruck reports that a ... concentration of the signaling molecule Hedgehog. The development ...
... Stockholm, Sweden and Addis Ababa, Ethiopia Current research ... The related report by Rahman et al, "Compartmentalization of ... cells but elevated levels of FoxP3+ regulatory T cells ... issue of The American Journal of Pathology . ...
Cached Biology News:Nobel Laureate underscores importance of investment in basic research 2Why the thumb of the right hand is on the left hand side 2TB -- hiding in plain sight 2
(Date:2/27/2015)... -- Bionomics Limited (ASX:BNO, ADR:BMICY) is to present important ... patients with metastatic renal cancer at the ASCO Genitourinary ... The data will be presented by Dr. Sumanta ... Center in California in his ... Ferritin and IL-8 as two baseline biomarkers that correlate ...
(Date:2/27/2015)... BOSTON , Feb. 27, 2015   PureTech ... identifying, inventing and commercializing disruptive products and technologies in ... Christopher Viehbacher , former CEO and Member of the ... Directors.  "It,s has been a pleasure ... very excited that we will be working together more ...
(Date:2/26/2015)... 2015   Synageva BioPharma Corp. (NASDAQ: ... therapeutic products for rare disorders, today reported 2014 ... other key objectives, and financial guidance.  Synageva,s management ... 4:30 p.m. EST to review the financial results ... in today,s call by telephone, please dial (877) ...
(Date:2/26/2015)... On behalf of biotech client GenScript ... Goldman & Spitzer, P.A. (Wilentz) secured a significant ... Inc. in excess of $10 million. The jury determined ... and that it improperly hired one or more of ... motions for judgment notwithstanding the verdict, a new trial, ...
Breaking Biology Technology:New BNC105 Biomarker Data to be Presented at US Cancer Conference 2New BNC105 Biomarker Data to be Presented at US Cancer Conference 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 5Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 3Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 4Synageva BioPharma Reports 2014 Full Year Financial Results 2Synageva BioPharma Reports 2014 Full Year Financial Results 3Synageva BioPharma Reports 2014 Full Year Financial Results 4Synageva BioPharma Reports 2014 Full Year Financial Results 5Synageva BioPharma Reports 2014 Full Year Financial Results 6Synageva BioPharma Reports 2014 Full Year Financial Results 7Synageva BioPharma Reports 2014 Full Year Financial Results 8Synageva BioPharma Reports 2014 Full Year Financial Results 9Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3
... hemostatic powder is available in ready-to-use applicator, ATLANTA, ... biomaterials, medical device and tissue processing company, announced,today that ... Hemostase MPH for use in general, cardiac and vascular ... U.S., the United,Kingdom and Germany in the second quarter ...
... References to the Brazilian,ethanol industry in the ... the Amsterdam-based non-government organization Friends of,the Earth, ... outdated,information that in no way reflects current ... comes from Marcos Sawaya Jank, president of ...
... and Products Offset Patent Expirations, SAN FRANCISCO, ... of major neuropathic pain (NP) conditions is currently ... a report released today by,WWMR, Inc. Growth over ... by the,successful launch of Lyrica (pregabalin) for diabetic ...
Cached Biology Technology:CryoLife Expands Distribution of Hemostase MPH(R) to France through Laboratoire Gamida 2CryoLife Expands Distribution of Hemostase MPH(R) to France through Laboratoire Gamida 3Friends of the Earth Report on Biofuel Production Offers Incomplete, Outdated and Inaccurate Picture, According to Brazilian Sugarcane Industry Association 2Friends of the Earth Report on Biofuel Production Offers Incomplete, Outdated and Inaccurate Picture, According to Brazilian Sugarcane Industry Association 3US Neuropathic Pain Market Value Doubles to $5 Billion by 2018 2US Neuropathic Pain Market Value Doubles to $5 Billion by 2018 3
... Ligands\n\nReceptor-related research has long been enabled by ... selected to keep pace with new discoveries. ... and services for receptor research and drug ... you do not find exactly what you ...
... UltraPure Agarose and SYBR Safe DNA Gel Stain ... Saves money versus buying these same products separately ... alternative to ethidium bromide ... Agarose resolves DNA and RNA fragments from 100 bp ...
... Odyssey images are easily imported for data analysis , ... ... , Extensive background and signal options to optimize, ... results , ...
... optimized for siRNA applications, contains magnetic nanoparticles ... nucleic acid of interest. Exploiting magnetic force ... rapidly drawn towards and delivered into the ... Reagent can be used for adherent cells; ...
Biology Products: