Navigation Links
Solving the puzzle of the BK ion channel
Date:6/23/2010

In 2004, Washington University in St. Lous researcher Jianmin Cui was handed a puzzling clue to the structure of an ion channel his lab had been studying for five years.

Scientists at the Cleveland Clinic Foundation in Ohio had located a large family whose members suffered from epilepsy, sudden attacks of involuntary movement or both, a syndrome called generalized epilepsy and paroxysmal dyskinesia (GEPD).

By analyzing the DNA of the 16 family members who had inherited the syndrome, the Cleveland Clinic scientists identified a mutation in the study family in the gene that encodes the big-conductance potassium ion channel (also known as the BK or MaxiK channel). This was one of the ion channels Cui, PhD, the Spencer T. Olin Associate Professor of Biomedical Engineering in the School of Engineering & Applied Science, had long studied.

Ion channels are small, highly selective pores in the cell membrane that allow specific ions (charged atoms) to enter or leave the cell. They are not continuously open but instead have gates, which open briefly and then close again in response to electrical, mechanical or chemical signals.

The mutation changes a single amino acid, or protein building block, in the BK channel.

The scientists thought that the mutation led to an increase in channel activity and thus nerve-cell excitability, causing epilepsy or involuntary movement, depending on which parts of the central nervous system were affected by the mutation.

But there was a problem. The altered amino acid was not part of the gate that opens and closes the channel.

Cui and his colleagues were thus faced with the problem of action at a distance. How did the mutation that apparently didn't interfere with the channel's gate nevertheless alter how often it was open?

Meticulous work that involved mutating other amino acids and testing the electrical properties of the mutated channels in frog eggs finally led to
'/>"/>

Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Brains problem-solving function at work when we daydream
2. Bowman Global Change says public engagement critical to solving climate crisis
3. Fossils and layers: Solving the terrane puzzle of the North American cordillera
4. Solving an avian scourge could also provide benefits to human health
5. New tool for resolving fisheries conflicts
6. Magnetic snakes control fluids, gravity-defying droplets, and solving a dragonfly mystery
7. McGill team discovers a piece of the puzzle for individualized cancer therapy via gene silencing
8. Key piece of puzzle sheds light on function of ribosomes
9. CSHL scientists harness logic of Sudoku math puzzle to vastly enhance genome-sequencing capability
10. New piece found in the puzzle of epigenetics
11. Biologists devise unifying framework to explain evolutionary puzzles
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Solving the puzzle of the BK ion channel
(Date:4/21/2015)... 2015 High crime rate, ... boosting access control systems market in Saudi ... recently published report by TechSci Research " Saudi Arabia Access ... control systems market in Saudi Arabia ... access control systems market in the Kingdom is growing ...
(Date:4/14/2015)... YORK , April 14, 2015  HYPR ... IDentity Online (FIDO ® ) Alliance tm , ... specifications. FIDO members commit to share technology and ... methods that are interoperable, more secure and private, ... enable biometric identity verification that protects sensitive user ...
(Date:4/10/2015)... , April 10, 2015 Research ... of the "Security Competitive Profiles - NEC" ... , NEC will continue to supply a ... the market, with a company focus on the development ... Winning opportunities in the Asia-Pacific ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3NEC Security Competitive Profile 2015 2
... Veterinary Medicine have identified a gene in Labrador retriever dogs ... intense hunting or retrieving exercise, activities these dogs are trained ... hind limbs. In most cases, their legs get wobbly ... dogs may die. Labradors are the most common dog ...
... mean solar or wind power. In fact, the alternative ... engineering professor James Dumesic look a lot like the ... That,s because the new fuels are identical at the ... is where they come from. Funded by the ...
... have succeeded in tracing intricate biochemical networks involving a ... in specific tissues at particular moments in development. ... Krainer, Ph.D., both professors at CSHL and heads of ... call RNA splicing. Splicing is a key step ...
Cached Biology News:U of M researchers identify gene linked to common ailment in labrador retrievers 2New process derives 'green gasoline' from plant sugars 2CSHL team traces extensive networks regulating alternative RNA splicing 2CSHL team traces extensive networks regulating alternative RNA splicing 3CSHL team traces extensive networks regulating alternative RNA splicing 4
(Date:4/27/2015)... 27, 2015 tru Shrimp™ Systems announced ... Texas A&M University for the exclusive worldwide rights to ... raceway systems. The license agreement for the patented technology, ... to countries such as China, Taiwan, France, Germany, Italy, ... “We have had inquires from all over the world ...
(Date:4/25/2015)... (PRWEB) April 25, 2015 Join us ... 29th: Analyzing Kinase Inhibitor Residence Times using the Transcreener® ... of inhibitor residence times is increasingly being incorporated into ... can result in improved efficacy, increased therapeutic window and ... determined using immobilized ligand methods such surface plasmon resonance, ...
(Date:4/24/2015)... McKinney, Texas (PRWEB) April 24, 2015 ... products for use in applications such as animal ... fat and oil reduction in wastewater treatment plants ... be an exhibitor at the National Restaurant Association’s ... 16-19. , Representatives of the company will ...
(Date:4/24/2015)... , April 24, 2015  Navitas Life Sciences is ... as Head of Clinical and Regulatory Services. Shalabh is a ... a co-founder and CEO of Kinapse, as well as a ... Logo - http://photos.prnewswire.com/prnh/20150423/201261LOGO ... Tizzard commented "I am delighted to welcome Shalabh into ...
Breaking Biology Technology:tru Shrimp™ Systems Acquires Global Patent for Tidal Basin™ Shrimp Production 2BellBrook Labs Webinar: Analyzing Kinase Inhibitor Residence Times using the Transcreener® ADP Assay 2DryLet to Showcase Bio-React at the National Restaurant Association’s NRA Show 2015 May 16-19, 2015 in Chicago, Illinois 2Shalabh Kumar Joins Navitas Life Sciences to Lead their Clinical and Regulatory Services Teams 2
... COLOGNE, Germany and BANGALORE, India ... its seventh laboratory worldwide in Electronics City in,the Indian city ... The world,leader in independent safety and quality testing for solar ... test centre, which in particular will,offer services to India,s ...
... , PINE BROOK, N.J. , Aug. 4 ... company, announced today that it has been awarded a second ... for the advanced development of Anthim for the prevention and ... is in addition to $16.8 million already received ...
... 4 /PRNewswire-FirstCall/ - Aeterna Zentaris Inc. (NASDAQ: AEZS, TSX: ... endocrinology, will announce its second quarter 2010 financial and operating results before ... host a conference call and webcast to discuss these results later that ... , , ...
Cached Biology Technology:New Test Centre in India: TUV Rheinland Continues Worldwide Investment Programme for Solar Industry 2New Test Centre in India: TUV Rheinland Continues Worldwide Investment Programme for Solar Industry 3Elusys Awarded Additional $40.6 Million Under Existing U.S. Government Contract to Fund Advanced Development of Anthim, a New Treatment for Anthrax 2Elusys Awarded Additional $40.6 Million Under Existing U.S. Government Contract to Fund Advanced Development of Anthim, a New Treatment for Anthrax 3
... Immunogen: Synthetic phosphopeptide corresponding to ... Ser603 residue of rat Synapsin ... synapsin I when phosphorylated at ... Rat (positive control: rat brain ...
EMBP (FL-222)...
... PhosphatidylEthanolamine-Binding Protein (PEBP) does not share ... inhibitors. PEBP is expressed in ... ovary, muscle, and stomach. One ... is exerting inhibitory activity against several ...
Anti-Rsk2/MAPKAP Kinase 1b, #0 SK2/MAPKAP K1 beta Smartpool&t 3T3 cell lysate Non-specific Control Pool , #D 1X Universal Buffer...
Biology Products: