Navigation Links
Solving the puzzle of cognitive problems caused by HIV infection
Date:7/1/2011

July 1, 2011 (Bronx, NY) A longstanding medical mystery why so many people with HIV experience memory loss and other cognitive problems despite potent antiretroviral therapy may have been solved by researchers at Albert Einstein College of Medicine of Yeshiva University. Their findings are published in the June 29 issue of The Journal of Neuroscience.

Even though antiretroviral treatment suppresses HIV replication and slows the progress of HIV disease, between 40 and 60 percent of HIV-infected people eventually develop mild-to-moderate neurological deficits, and up to 5 percent develop full-blown dementia. Until now, researchers have not been able to explain why these complications, collectively known as neuroAIDS, occur.

In a previous study, the Einstein researchers found that HIV infects about 5 percent of brain cells known as astrocytes. These cells bolster the blood-brain barrier, a network of blood vessels that prevents harmful substances from crossing into the brain from the bloodstream. In the present study, the researchers show that even this low-level of astrocyte infection can profoundly damage the blood-brain barrier.

"The relatively few infected astrocytes emit toxic signals through specialized channels that kill neighboring uninfected astrocytes, ultimately weakening the blood-brain barrier and allowing harmful compounds to enter the brain," said senior author Joan Berman, Ph.D., professor of pathology and of microbiology & immunology at Einstein.

The evidence came from a laboratory model of the blood-brain barrier constructed of human cells and from examining brain tissue of macaque monkeys infected with the simian form of HIV. The results suggest that drugs capable of reducing the damaging signaling cascades triggered by HIV-infected astrocytes might help in preventing or treating neuroAIDS.


'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. Horticulture students link problem-solving to employment
2. Solving the puzzle of Henry VIII
3. Solving the riddle of natures perfect spring
4. Toward resolving Darwins abominable mystery
5. Solving the puzzle of the BK ion channel
6. Brains problem-solving function at work when we daydream
7. Bowman Global Change says public engagement critical to solving climate crisis
8. Researchers solve mammoth evolutionary puzzle: The woollies werent picky, happy to interbreed
9. Selaginella genome adds piece to plant evolutionary puzzle
10. Several baffling puzzles in protein molecular structure solved with new method
11. The puzzle of biological diversity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... -- Research and Markets has announced the addition of ... their offering. The report forecasts ... grow at a CAGR of 12.28% during the period 2016-2020. ... market analysis with inputs from industry experts. The report covers the ... report also includes a discussion of the key vendors operating in ...
(Date:6/22/2016)... , June 22, 2016  The American College of ... Trade Show Executive Magazine as one of the fastest-growing ... May 25-27 at the Bellagio in Las Vegas ... the highest percentage of growth in each of the following ... exhibiting companies and number of attendees. The 2015 ACMG Annual ...
(Date:6/22/2016)... , June 22, 2016   ... management and verification solutions, has partnered with ... software solutions for Visitor Management, Self-Service Kiosks ... provides products that add functional enhancements to ... provides corporations and venues with an automated ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the ... the Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s ... how hardware projects are designed, built and brought to market. , The Design ...
(Date:6/23/2016)... 23, 2016  Blueprint Bio, a company dedicated to ... medical community, has closed its Series A funding round, ... "We have received a commitment from Forentis ... need to meet our current goals," stated Matthew ... runway to complete validation on the current projects in ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... and technical consulting, provides a free webinar on Performing Quality Investigations: ... 2016 at 12pm CT at no charge. , Incomplete investigations are still a ...
(Date:6/22/2016)... DIEGO , June 22, 2016 ... that will allow them to produce up to ... from one lot within one week. These high-quality, ... time laboriously preparing cells and spend more time ... possible through a proprietary, high-volume manufacturing process that ...
Breaking Biology Technology: