Navigation Links
Solving stem cell mysteries
Date:10/26/2012

Baltimore, MD The ability of embryonic stem cells to differentiate into different types of cells with different functions is regulated and maintained by a complex series of chemical interactions, which are not well understood. Learning more about this process could prove useful for stem cell-based therapies down the road. New research from a team led by Carnegie's Yixian Zheng zeroes in on the process by which stem cells maintain their proper undifferentiated state. Their results are published in Cell October 26.

Embryonic stem cells go through a process called self-renewal, wherein they undergo multiple cycles of division while not differentiating into any other type of cells. This process is dependent on three protein networks, which guide both self-renewal and eventual differentiation. But the integration of these three networks has remained a mystery.

Using a combination of genetic, protein-oriented and physiological approaches involving mouse embryonic stem cells, the teamwhich also included current and former Carnegie scientists Junling Jia, Xiaobin Zheng, Junqi Zhang, Anying Zhang, and Hao Jianguncovered a mechanism that integrates all three networks involved in embryonic stem cell self-renewal and provide a critical missing link to understanding this process.

The key is a protein called Utf1. It serves three important roles. First, it balances between activating and deactivating the necessary genes to direct the cell toward differentiation. At the same time, it acts on messenger RNA that is the transcription product of the genes when they're activated by tagging it for degradation, rather than allowing it to continue to serve its cellular function. Lastly, it blocks a genetic feedback loop that normally inhibits cellular proliferation, allowing it to occur in the rapid nature characteristic of embryonic stem cells.

"We are slowly but surely growing to understand the physiology of embryonic stem cells," Zheng
'/>"/>

Contact: Yixian Zheng
zheng@ciwemb.edu
410-246-3032
Carnegie Institution
Source:Eurekalert

Page: 1 2

Related biology news :

1. Are methane hydrates dissolving?
2. Solving the stink from sewers
3. Speed and power of X-ray laser helps unlock molecular mysteries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... VIEW, Calif. , Nov. 20, 2014 ... higher driver efficiency are piloting the North American and ... number of accidents growing, gesture recognition systems that are ... make a mark in the industry. ... the Automotive Gesture Recognition Market in Europe ...
(Date:11/18/2014)... , Nov. 17, 2014   ... and EMC collaborate to develop The Partners Data ... , The Partners Data Lake will allow researcher ... improve diagnostics, treatment and the lives of patients ... research and clinical activities across the Partners system, ...
(Date:11/12/2014)... , Nov. 12, 2014 Crossmatch™, a leading ... its U.are.U ® fingerprint readers have been deployed ... Central Mexico . The bakery chain ... eliminate payroll issues caused by employees clocking in for ... U.are.U fingerprint readers, Montparnasse relied on paper timecards and ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... Spring Harbor, N.Y. Much like cancer cells, plant ... normal milieu, in culture dishes, have highly unstable genomes. ... help cells cope with challenging culture conditions but inadvertently ... bits of DNA that can jump around in the ...
... change will reach a tipping point in less than ... of the planet,s coral reef ecosystems according to the ... by the Global Coral Reef Monitoring Network and the ... "Status of Coral Reefs of the World: 2008" provides ...
... State University chemist could eventually lead to a quicker ... key to treating a number of diseases, including cancer, ... and research often are made within genetically modified ... to collect into what scientists call inclusion bodies. Those ...
Cached Biology News:CSHL researchers map changing epigenetic modifications that enable transposons to run amok 2Time running out on coral reefs as climate change becomes increasing threat 2Time running out on coral reefs as climate change becomes increasing threat 3
(Date:12/17/2014)... Texas , Dec. 16, 2014  Vermillion, Inc. ... focused on gynecologic disease, today announced the next step ... a premier bio-analytics solutions provider with the naming of ... President and Chief Executive Officer, while current Chairman of ... continue to serve as Chairman. These changes are effective ...
(Date:12/17/2014)... LEXINGTON, Mass. , Dec. 17, 2014   ... a biopharmaceutical company developing therapeutic products for rare disorders, ... Healthcare Conference being held in San Francisco, ... , President and Chief Executive Officer, will present on ... p.m. EST).  The presentation will be webcast live and ...
(Date:12/15/2014)... NEW YORK , Dec. 15, 2014  GlassesOff ... Yuval Bar-Gil as an independent director of ... was founder of AeroScout and served as its CEO ... Decker in 2012, a $240 million transaction. Recognized as ... under Mr. Bar-Gil,s leadership, AeroScout provided Wi-Fi -based RFID ...
(Date:12/13/2014)... , Dec. 12, 2014 /CNW/ - MaRS and Virgin ... today that they have joined forces to support Canadian entrepreneurs ... , Virgin Group Founder was at the MaRS Centre to ... new, national impact venture fund. This fund has $1 million ... Vancouver -based Mindset Social Innovation Foundation, founded ...
Breaking Biology Technology:Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3MaRS and Virgin Unite partner to invest in business as a force for good 2MaRS and Virgin Unite partner to invest in business as a force for good 3
... Barr Pharmaceuticals,Inc. (NYSE: BRL ) today announced ... Jersey has ruled in favor of its subsidiary, Barr,Laboratories, ... Bayer Schering,Pharma, AG in connection with Bayer Schering,s Yasmin(R) ... Peter G.,Sheridan found that the patent at issue was ...
... Iomai Corporation,(Nasdaq: IOMI ) today announced that ... before the markets open and hold a,conference call and ... March 6, 2008 at 1:30 p.m. Eastern Time., ... call on Thursday, March 6 at 1:30 p.m.,Eastern Time ...
... in a row,the capital markets succumbed to fears of inflation ... the Dow dropped over 300 points after,oil prices pushed past ... was dragged down with the Burrill Biotech Select Index,dropping 4% ... closed down,3%., "The biotech sector started 2008 on a ...
Cached Biology Technology:Barr Announces Favorable Ruling in Yasmin(R) Patent Challenge 2Barr Announces Favorable Ruling in Yasmin(R) Patent Challenge 3Barr Announces Favorable Ruling in Yasmin(R) Patent Challenge 4Iomai to Announce Fourth Quarter and Year-End 2007 Financial Results and Host Webcast on Thursday, March 6 2Biotech Drops Amid Tough Markets in February 2Biotech Drops Amid Tough Markets in February 3
Anti-Cohesin (Scc1/Rad21) Monoclonal Antibody Research Focus: signal transduction Storage: -20C Shipping Temperature: +4C...
Proline-serine-threonine phosphatase-interacting protein 2...
Anti-gamma Glutamyl Transferase (gammaGT) Host: mouse monoclonal Species Reactivity: human Applications: WB, IP, FC Storage: 4C...
... Goat polyclonal to Cholesterol Oxidase ... / Specificity Cross-reacts with bacteria. Not ... Information Cholesterol oxidases exist as both ... are implicated in bacterial pathogenesis. In addition, ...
Biology Products: