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Solving an evolutionary puzzle
Date:2/12/2014

For four decades, waste from nearby manufacturing plants flowed into the waters of New Bedford Harboran 18,000-acre estuary and busy seaport. The harbor, which is contaminated with polychlorinated biphenyls (PCBs) and heavy metals, is one of the EPA's largest Superfund cleanup sites.

It's also the site of an evolutionary puzzle that researchers at Woods Hole Oceanographic Institution (WHOI) and their colleagues have been working to solve.

Atlantic killifishcommon estuarine fishes about three inches longare not only tolerating the toxic conditions in the harbor, they seem to be thriving there. How have they been able to adapt and live in such a highly contaminated environment?

In a new paper published in BMC Evolutionary Biology, researchers found that changes in a receptor protein, called the aryl hydrocarbon receptor 2 (AHR2), may explain how killifish in New Bedford Harbor evolved genetic resistance to PCBs.

Killifish are prey fish that do not migrate. They live their whole lives in the same area, generally within a few hundred yards of the spot where they were hatched. Unlike fish that may come in and out of the harbor sporadically during the summer months to feed, the killifish are there year round and spend winters burrowing into the contaminated sediment.

Normally when fish are exposed to harmful chemicals, the body steps up production of enzymes that break down the pollutants, a process controlled by the AHR2 protein. Some of the PCBs are not broken down in this way, and their continued stimulation of AHR2 disrupts cellular functions, leading to toxicity. In the New Bedford Harbor killifish, the AHR2 system has become resistant to this effect.

"The killifish have managed to shut down the pathway," said Mark Hahn, a biologist at WHOI and coauthor of the paper. "It's an example of how some populations are able to adapt to changes in their environmenta snapshot of evolution at work."

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Woods Hole Oceanographic Institution
Source:Eurekalert  

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