Navigation Links
Software helps synthetic biologists customize protein production
Date:7/21/2011

A software program developed by a Penn State synthetic biologist could provide biotechnology companies with genetic plans to help them turn bacteria into molecular factories, capable of producing everything from biofuels to medicine.

"It's similar to how an engineer designs a plane or a car," said Howard M. Salis, assistant professor in agricultural and biological engineering, and chemical engineering. "When designing a biological organism, there are many combinations that the engineer must test to find the best combination. This technology allows us to quickly identify the best DNA sequence for a particular biotechnological application."

The program, called a DNA compiler, designs synthetic DNA sequences to control protein production inside simple organisms. Salis said narrowing down the exact genetic plans from the billions of possible sequence combinations will save biotechnology companies money and time.

To produce proteins, which are integral for creating and maintaining cells, an organism's DNA sequence controls the proteins that it makes and how much of each protein is produced.

DNA serves as a genetic template to create messenger RNA -- mRNA. Another form of RNA, transfer RNA, carries amino acids, the components of proteins, as ingredients for the proteins.

The software predicts how fast an organism will produce a specific protein. It can also design new DNA sequences to increase or decrease protein production across a large scale and to find the best protein production rates.

Salis, whose work appears in a recent issue of Methods in Enzymology, said that synthetic DNA sequences will play a more important role in industries as diverse as medicine and manufacturing. The biofuel industry is particularly interested in maximizing the amount of proteins produced to optimize metabolism. To be profitable, companies have to produce large quantities of biofuels.

"We're learning how to predict, control and design the behavior of biological organisms," said Salis. "We can do it much faster than evolution."

In one of the software's modes, genetic engineers can type strings of letters A, T, G and C that represent adenine, thymine, guanine and cystosine -- molecules in DNA-- into the software, which then calculates which protein will be made and how much protein will be produced, said Salis. In another mode, engineers select a protein's production rate inside the organism and the software optimizes a synthetic DNA sequence to achieve that rate.


'/>"/>

Contact: Matt Swayne
aem1@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Related biology news :

1. New software aids fight against nitrates in Floridas groundwater
2. CU researchers develop new software to advance brain image research
3. Signaling pathway is executive software of airway stem cells
4. Open-source software designed to minimize synthetic biology risks
5. SoftGenetics to Supply Forensic Analysis Software for IntegenXs Automated DNA Identity Profiling System
6. New software quantifies leaf venation networks, enables plant biology advances
7. High-tech software, umanned planes allow scientists to keep tabs on Arctic seals
8. New software eases analysis of insect in motion
9. Aware to Introduce Several New Software Products at the Biometrics Consortium Conference
10. SailPoint Signs International Reseller Agreement with BMC Software
11. Systems biology software package developed at VBI is now open source for all users
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/2/2019)... ... November 01, 2019 , ... Stay on top of current hot topics ... Access to all webinars is free, so be sure to register today to save ... http://www.xtalks.com to see our upcoming webinars: , CLINICAL OPERATIONS , November 14 ...
(Date:10/30/2019)... ... October 30, 2019 , ... Analogous to ... encoded by the ordering of monomer residues into specific sequences along their ... attachment to the backbone amide-nitrogen atoms. They are resistant to protease degradation ...
(Date:10/26/2019)... ... October 23, 2019 , ... ... Christina Hughes , to its executive leadership team. , As a market leader ... allow growth-stage biotech and pharma companies to reduce timelines and improve quality with ...
Breaking Biology News(10 mins):
(Date:11/12/2019)... ... November 12, 2019 , ... ... software solutions for biopharmaceutical R&D, today announced that Immatics Biotechnologies , ... Genedata Biologics® to streamline their R&D operations related to the ...
(Date:11/9/2019)... ... November 08, 2019 , ... PathAI, a ... today announced the results of analyses examining the severity of nonalcoholic steatohepatitis ... selonsertib studies (STELLAR). Strong correlations were demonstrated between AI-powered and manual pathologist ...
(Date:11/5/2019)... ... 2019 , ... Focal Healthcare , an innovator of ... Bx 2.0 prostate fusion biopsy solution. By combining information from multiparametric MRI (mpMRI) ... urologists across Europe the ability to perform targeted transrectal and transperineal prostate biopsies. ...
(Date:11/2/2019)... ... October 31, 2019 , ... drug360 ... intelligence pioneer tellic. drug360 brings tellic’s expertise in biomedical language processing and ... to quickly uncover relationships between genes, diseases, variants, phenotypes, and other biomedical entities. ...
Breaking Biology Technology: