Navigation Links
Soft drink could enhance effects of an anticancer drug
Date:11/10/2010

Experiments with an artificial stomach suggest that a popular lemon-lime soft drink could play an unexpected role in improving the effectiveness of an oral anticancer drug. The experiments produced evidence that patients will absorb more of the unnamed drug, tested in Phase I in clinical trials, when taken with "flat" or degassed Sprite. The study appears in ACS' Molecular Pharmaceutics, a bi-monthly journal.

Faraj Atassi and colleagues note that efforts are underway to develop more anticancer medications that patients can take by mouth. However, biological variations among patients due to variations in stomach acidity and other factors can reduce the effectiveness of oral anticancer drugs. Such was the case with the unnamed anticancer drug in the study, identified only as "Compound X." There were wide differences in how the drug was absorbed in the first patients who took it.

The scientists combined Compound X with Captisol, a substance that helps improve the solubility of drug ingredients, and turned to the artificial stomach. That glass-and-plastic device is used to study how drugs and foods dissolve through the GI tract. They showed that Sprite seemed to control stomach acidity in a way likely to allow greater absorption of the drug into the body. Based on the results, the scientists suggest that patients in future clinical trials take the drug with Sprite.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Drinking 100 percent fruit juice is linked to higher intake of essential nutrients
2. $7.5M grant to fund research on interaction of drinking and HIV infection
3. Electrified nano filter promises to cut costs for clean drinking water
4. Drink milk and lose more weight, according to Ben-Gurion University of the Negev research
5. Manganese in drinking water: Study suggests adverse effects on childrens intellectual abilities
6. New study finds milk drinkers may have a healthy weight advantage
7. Energy drinks may give young sports teams an edge, study says
8. School-based intervention successfully lowers drinking rates in at risk children
9. Bees warm up with a drink, too!
10. Research shows sugary drinks do not cause weight gain
11. Drinking alcohol during pregnancy may damage semen quality in sons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... , June 9, 2016  Perkotek an innovation leader in attendance control systems ... seamlessly log work hours, for employers to make sure the right employees are actually ... http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
(Date:6/3/2016)... , June 3, 2016 ... von Nepal hat ... Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung ... in der Produktion und Implementierung von Identitätsmanagementlösungen. ... Ausschreibung im Januar teilgenommen, aber Decatur wurde ...
(Date:6/2/2016)... -- Perimeter Surveillance & Detection Systems, Biometrics ... Support & Other Service  The latest report ... analysis of the global Border Security market . ... $17.98 billion in 2016. Now: In November ... software and hardware technologies for advanced video surveillance. ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... , Nov. 30, 2016  Tempus, a technology ... care, and Penn,s Abramson Cancer Center have partnered ... positive response to immunotherapy treatment based on next ... As part of a research collaboration, Tempus will ... melanoma cancer patient data to Penn. Utilizing next-generation ...
(Date:11/30/2016)... 30, 2016 Part of 5m$ Investment ... ... Aptuit, LLC today announced that it had successfully completed ... novel compounds have increased the Screening Collection to over 400,000. ... discovery capabilities of the company. This expansion, complemented by new ...
(Date:11/30/2016)... Woburn, MA (PRWEB) , ... November 30, 2016 ... ... broadband light sources for advanced technology applications, introduces the 5th generation, ultra-bright, Laser-Driven ... the highly successful Laser-Driven Light Source (LDLS™) technology, the EQ-77 offers higher radiance ...
(Date:11/30/2016)... ... November 30, 2016 , ... With growth rates averaging ... after five years and look forward to continuing their expansion in their new office ... area which has been traditionally favoured by the creative industries, so Random42 Scientific Communication ...
Breaking Biology Technology: