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Sodium transporter appears likely target for treating salt-sensitive hypertension
Date:2/26/2013

sensitivity, reduced oxidative stress and reduced renal injury when you feed these animals a high-salt diet," O'Connor said.

If he's correct, targeted treatment for salt-sensitive hypertension may emerge. "We think it might be an interesting target to help inhibit oxidative-stress related cardiovascular disease," O'Connor said.

Although free radicals are a known contributor to cardiovascular disease, antioxidants haven't proven effective therapy, said O'Connor, who would like to directly inhibit the source of free radicals rather than scavenge for them once they are formed. An estimated 1-in-50 patients in the United States develop treatment-resistant hypertension, which increases the risk of heart attack, stroke and other complications, according to studies published in the American Heart Association journal Circulation.

HV1 was discovered in 2006 in immune cells where is helps ensure the proper activity of the enzyme NADPH oxidase, which actually produces free radicals. It's now been found in a variety of cell types, and scientists are exploring its potential role in maladies such as ischemic stroke and cancer. O'Connor notes that his HIV mutant rats do not appear to have a compromised immune system.

O'Connor joined the MCG faculty in 2011.


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Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University
Source:Eurekalert  

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