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Sodium transporter appears likely target for treating salt-sensitive hypertension
Date:2/26/2013

AUGUSTA, Ga. Genetics and demographics likely put you at risk for salt-sensitive hypertension, and scientists are looking for a way to protect you.

The concept is that free radicals in the kidney prompt the organ to hold onto sodium rather than eliminate excess through urination. Excess sodium, in turn, increases free radical production, said Dr. Paul O'Connor, hypertension researcher in the Section of Experimental Medicine at the Medical College of Georgia at Georgia Regents University.

Blocking the hydrogen transporter HVI best known for its role in helping immune cells produce large amounts of free radicals to kill bacteria may stop the unhealthy, vicious cycle.

"We think HVI overexpression in the kidney fuels the production of too many free radicals, which can activate the sodium transporters to hold onto more sodium, leading to hypertension and kidney damage," O'Connor said.

With the help of a New Investigator Award from the American Heart Association and a HV1 mutant rat, he plans to find out.

Sodium helps the kidneys regulate fluid volume and blood pressure. However being older, black and obese are risk factors for holding onto too much sodium. Nearly 40 percent of blacks and 30 percent of whites with healthy blood pressure have a tendency to hold onto salt and so-called salt sensitivity occurs in nearly 75 percent of blacks and more than half of whites with hypertension.

O'Connor has found HVI in the nephrons of the kidneys where decisions are made about how much sodium to retain. And, when looking at sodium transport inside renal tubule cells, he found a drug he was using inhibited free radical production and started putting the pieces together.

O'Connor and his collaborators developed the HV1 mutant of the Dahl salt-sensitive rat, which becomes hypertensive on a high-salt diet, to test the emerging hypothesis.

"We think if HV1 is not present, you will have reduced salt
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Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University
Source:Eurekalert  

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