Navigation Links
Socially isolated rats are more vulnerable to addiction, report researchers
Date:1/23/2013

amine and alcohol.

The results were striking, said Mickal Degoulet, a postdoctoral researcher in Morikawa's lab. The isolated rats were much quicker to form a preference for the small, distinctive box in which they received amphetamine or alcohol than were the never-isolated control group. Nearly all the isolated rats showed a preference after just one exposure to either drug. The control rats only became conditioned after repeated exposures.

Morikawa said that this kind of preference for the environmental context in which the reward was received provides researchers with a more useful way of understanding addiction than seeing it as a desire for more of the addictive substance.

"When you drink or take addictive drugs, that triggers the release of dopamine," he said. "People commonly think of dopamine as a happy transmitter or a pleasure transmitter, which may or may not be true, but it is becoming increasingly clear that it is also a learning transmitter. It strengthens those synapses that are active when dopamine is released. It tells our brain that what we're doing at that moment is rewarding and thus worth repeating."

In an important sense, says Morikawa, you don't become addicted to the experience of pleasure or relief but to the constellation of environmental, behavioral and physiological cues that are reinforced when the substance triggers the release of dopamine in the brain.

Morikawa and Whitaker have also been able to document these changes at the neuronal level. Social isolation primes dopamine neurons in the rats' brain to quickly learn to generate spikes in response to inputs from other brain areas. So dopamine neurons will learn to respond to the context more quickly.

If the control, group-housed rats are given enough repeated exposure to amphetamine, they eventually achieve the same degree of addiction as the socially isolated rats. Even from this point of comparable addiction, however, there are d
'/>"/>

Contact: Daniel Oppenheimer
daniel.oppenheimer@utexas.edu
512-745-3353
University of Texas at Austin
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related biology news :

1. Cancer stem cells isolated from kidney tumors
2. Increasing drought stress challenges vulnerable hydraulic system of plants, GW professor finds
3. The challenges facing the vulnerable Antarctic
4. Energy requirements make Antarctic fur seal pups vulnerable to climate change
5. Crabs, insects and spiders vulnerable to oil spill, but also resilient
6. New study will help protect vulnerable birds from impacts of climate change
7. Invading species can extinguish native plants despite recent reports
8. Study reports iron oxide nanoparticles effective for labeling human endothelial cells
9. Report from the front lines of personalized reproductive medicine revolution
10. New report finds increase in media coverage of synthetic biology
11. Cell Transplantation reports islet cell advancement increases impact on transplantation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Socially isolated rats are more vulnerable to addiction, report researchers
(Date:6/19/2013)... June 19, 2013 A study published in the ... the first report of an oral probiotic supplement significantly ... , The lead author on the study, Mitchell ... Presentation Prize from the New York Academy of Sciences ... week,s Probiotics, Prebiotics, and the Host Microbiome: The ...
(Date:6/19/2013)... the Marine Biological Laboratory (MBL), Woods Hole, Massachusetts, ... by the American Society for Microbiology (ASM). ... and the scientists who worked there that have ... microbiology. A ceremony unveiling the plaque that ... June 22, 2013, at 4:30 pm in the ...
(Date:6/19/2013)... A team of researchers at the University of ... outer coating of HIV, that could be potential ... avoid generating resistance. These new agents are quite ... The research was published in the June 2013 ... Chemotherapy . , The first of many probable ...
Breaking Biology News(10 mins):Study shows probiotic Lactobacillus reuteri NCIMB 30242 significantly increased vitamin D levels 2Microbial diversity course designated as a 'Milestones in Microbiology' site 2HIV-derived antibacterial shows promise against drug-resistant bacteria 2
... under scrutiny lately due to adverse cardiovascular side-effects stemming ... models, researchers reveal another adverse effect of Celecoxib; this ... independent of the COX-2 enzyme. Satpal Singh ... rate of Drosophila, a good model for human cardiac ...
... friends used to think he was eccentric, crawling like ... Pennsylvania, hauling dental tools and a jack hammer. ... gotten over it, and are congratulating him on receiving ... Society, presented at the Geological Society of Americas recent ...
... of medical and scientific books and journals, was ... content is immediately available on www.springerlink.com ... and more than 22,000 eBooks. Beginning with the ... purchase Humana Press journals through Springer. All issues ...
Cached Biology News:Academy volunteer wins national paleontology award 2Humana Press journals now available on SpringerLink 2
(Date:6/19/2013)... Raleigh, NC (PRWEB) June 19, 2013 ... and eclinical commerce network for clinical trials, today ... technology at DIA 2013 (booth #2000) in Boston, ... is the industry’s first and only fully configurable, ... technology, ClinPay®, the flagship module within Clinverse’s eClinical ...
(Date:6/19/2013)... 19, 2013  Continuing its long history of proven ... Beckman Coulter , Inc. announces the U.S. Food and ... AccuTnI+3 troponin I assay for use on its Access ... on Beckman Coulter,s troponin I test for ... the proven performance to continue providing dependability to laboratories ...
(Date:6/19/2013)... 2013 Today DuPont Executive Vice President ... become leaders in the greatest challenge facing our time ... 2050. Borel spoke at the International Food ... about urgent need for students to contribute their time ... sustainable and reached in collaboration with others. , “Food ...
(Date:6/19/2013)... Bloomington, Indiana (PRWEB) June 19, 2013 ... Valentine joined the speaking faculty at 2013’s BioLogistics ... , The conference, coordinated by Cold Chain IQ ... surrounding biologics. This “complexity” is, in part, attributed ... medicine. , “Implicit within these trends is ...
Breaking Biology Technology:Clinverse, Inc. Exhibiting and Showcasing Its Technology at DIA 2013 2Beckman Coulter Announces FDA Clearance of New Access AccuTnI+3 Troponin I Assay for the Access 2 Immunoassay System 2Beckman Coulter Announces FDA Clearance of New Access AccuTnI+3 Troponin I Assay for the Access 2 Immunoassay System 3DuPont Leader Calls for New Generation of Food Visionaries to Fight Hunger 2BioConvergence® Presents at BioLogistics Summit on Risk Matrix for Biosamples during Shipment 2
... Chindex International,Inc. (Nasdaq: CHDX ), an independent ... products in the People,s,Republic of China, today announced ... ended March 31, 2008., For the 2008 ... $130.1,million, an increase of 23% over the prior ...
... Takes Prominent Position and ... WEST SENECA, N.Y., June 11 Palladian Muscular Skeletal,Health ... a high-profile presence at a leading healthcare event -- ... June,18 to Friday, June 20, 2008., "We have ...
... Rosetta Genomics has Signed a Binding Term Sheet to Acquire Parkway ... ... Significantly Streamline the Development and Commercialization of Rosetta Genomics, microRNA-based ... Needs to Market and Sell its microRNA-based Tests in the U.S. and ...
Cached Biology Technology:Chindex International, Inc. Announces Fiscal 2008 Year End and Fourth Quarter Results 2Chindex International, Inc. Announces Fiscal 2008 Year End and Fourth Quarter Results 3Chindex International, Inc. Announces Fiscal 2008 Year End and Fourth Quarter Results 4Chindex International, Inc. Announces Fiscal 2008 Year End and Fourth Quarter Results 5Chindex International, Inc. Announces Fiscal 2008 Year End and Fourth Quarter Results 6Chindex International, Inc. Announces Fiscal 2008 Year End and Fourth Quarter Results 7Chindex International, Inc. Announces Fiscal 2008 Year End and Fourth Quarter Results 8Chindex International, Inc. Announces Fiscal 2008 Year End and Fourth Quarter Results 9Chindex International, Inc. Announces Fiscal 2008 Year End and Fourth Quarter Results 10Palladian Muscular Skeletal Health (formerly Prism Health Networks) to Promote Collaborative, Expanded Practice Model at Major Insurance Conference in June 2Rosetta Genomics Executes Binding Term Sheet to Acquire U.S. CLIA-Certified Lab to Expedite Commercialization of Diagnostic Tests 2Rosetta Genomics Executes Binding Term Sheet to Acquire U.S. CLIA-Certified Lab to Expedite Commercialization of Diagnostic Tests 3Rosetta Genomics Executes Binding Term Sheet to Acquire U.S. CLIA-Certified Lab to Expedite Commercialization of Diagnostic Tests 4Rosetta Genomics Executes Binding Term Sheet to Acquire U.S. CLIA-Certified Lab to Expedite Commercialization of Diagnostic Tests 5Rosetta Genomics Executes Binding Term Sheet to Acquire U.S. CLIA-Certified Lab to Expedite Commercialization of Diagnostic Tests 6
... Rabbit polyclonal to Taura ... Abpromise for all tested ... Synthetic peptide: VTNSEGSTIL MNDIPITNQN ... ATEFNQ, corresponding to N terminal ...
Goat polyclonal to SART3 ( Abpromise for all tested applications). Antigen: Synthetic peptide: MSNADFAKLFLRK, corresponding to C terminal amino acids 951-963 of Human SART3 Entrez Gene ID: 9...
... Immunogen: KLH-conjugated, synthetic peptide ... which [ Ac K] corresponds to acetyl ... Accession Number: NM_003493 ... Quality Assurance: Routinely ...
Blank Calibration Particles, 3.0-3.4 mu m 5 ml...
Biology Products: