Navigation Links
Social stress leads to atherosclerosis
Date:12/6/2010

Studies on genetically engineered mice show that social stress activates the immune system and accelerates the development of atherosclerosis. Commonly used drugs to reduce blood pressure, however, may stop this process. This is the conclusion of a thesis presented at the University of Gothenburg, Sweden.

Several large studies have clearly shown that there is a correlation between psychosocial stress and the risk of developing cardiovascular disease. However, little is known about why this is the case.

"The aim of my thesis was to study the underlying mechanisms by which stress leads to atherosclerosis and subsequent cardiovascular disease", explains Evelina Bernberg, researcher at the Department of Molecular and Clinical Medicine, at the Sahlgrenska Academy.

The study has been conducted using mice that have been genetically modified to spontaneously develop atherosclerosis. Using mice as experimental animals allows the scientists to study cause and effect relationships in a controlled situation.

"We found that situations that disrupt the social environment in which the mice normally live increased atherosclerosis, while more physical forms of stress did not", explains Evelina Bernberg.

The scientists discovered that social stress increased blood levels of different markers of inflammation - which previously have been shown to accelerate the development of atherosclerosis.

"When the sympathetic nervous system is activated, adrenalin is released and this increases the heart rate. We also found some evidence that the sympathetic nervous system is responsible for the release of these inflammatory markers", Evelina Bernberg relates.

This release could be reduced by commonly used blood pressure medication, beta-blockers. The same beta-blockers also reduced atherosclerosis and the release of inflammatory markers in unstressed mice, showing that the sympathetic nervous system plays an important rol
'/>"/>

Contact: Evelina Bernberg
evelina.bernberg@wlab.gu.se
46-070-361-0791
University of Gothenburg
Source:Eurekalert

Page: 1 2

Related biology news :

1. Natural and social sciences: ICSU embraces the need to work more closely together
2. Social interactions can alter gene expression in the brain, and vice versa
3. International Journal of Social Robotics debuts at Springer
4. How mirror neurons allow us to learn and socialize by going through the motions in the head
5. 2 genes influence social behavior, visual-spatial performance in people with Williams syndrome
6. Social support during breast-feeding helps humans have more children
7. Execretion analysis aids primate social studies
8. LabRoots Launches Social Networking Site for Scientists & Engineers
9. Social separation stops flu spread, but must be started soon
10. Researchers find genetic link between physical pain and social rejection
11. Making the case for the social sciences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... team of biologists, led by Clemson University associate professor ... pest that will pave the way for novel anti-fouling ... for medical and industrial applications. , The team,s findings, ... the last larval stage of barnacles that attaches to ... possibly polymeric material that acts as an underwater heavy-duty ...
(Date:7/30/2014)... today announced an across-the-board increase in Impact Factors ... InCites Journal Citation Reports (Thomson Reuters, 2014) show ... , Essays in Biochemistry , Biochemical ... all received increases in their Impact Factors. The ... published by Portland Press Limited. , 2014 Impact ...
(Date:7/30/2014)... professor from Wayne State University,s College of Engineering ... Science Foundation for the project, "Nanoparticle-directed synthesis of ... Science Foundation, nanotechnology is the creation and utilization ... properties and functions. A major bottleneck in scaling ... that connect different functional materials into one device. ...
Breaking Biology News(10 mins):Study: Marine pest provides advances in maritime anti-fouling and biomedicine 2Across-the-board Impact Factor increases for Portland Press Limited 2NSF grant to Wayne State supports new concept for manufacturing nanoscale devices 2
... mean lighting more bush fires, ecologists have proposed. ... threatened by encroaching woodland that is destroying their habitat, ... and Stanford University (USA) has shown. "Broad-headed snakes ... km of Sydney, and those small communities are fast ...
... Over the past few years, honey bee keepers have experienced ... honey bee populations, causing some growers of fruits, nuts and ... the future. A new study published in the Annals ... bees, which are not affected by CCD, may serve as ...
... team of scientists from the National Institute of Oceanography ... expedition on research vessel Polarstern. The cooperative project Lohafex ... But it has dampened hopes on the potential of ... dioxide (CO 2 ) and thus mitigate global warming. ...
Cached Biology News:Australia's most endangered snake might need burning 2Wild bees can be effective pollinators 2Lohafex provides new insights on plankton ecology 2Lohafex provides new insights on plankton ecology 3Lohafex provides new insights on plankton ecology 4
(Date:7/30/2014)... July 30, 2014 Yuma Regional ... and complementary therapies brings comprehensive cancer care to ... Yuma Regional Cancer Center has officially opened. A ... program includes services such as open, semi-private and ... American Cancer Society Resource Center, hematology, rehabilitation center, ...
(Date:7/30/2014)... July 30, 2014 Researchers often use ... biology, but such devices can do much more ... As such, researchers have looked to patterned assemblies ... metabolic engineering to characterize – and potentially ... devices are envisioned to recreate animal and human ...
(Date:7/30/2014)... , July 30, 2014  RXi Pharmaceuticals ... biotechnology company focused on discovering, developing and ... needs using RNA-targeted technologies, today announced that ... RXI-109, for the reduction of recurrence of ... has been initiated. Logo - ...
(Date:7/30/2014)... Diego, CA (PRWEB) July 30, 2014 ... contract from the U.S. Environmental Protection Agency (EPA). ... expertise in developmental toxicity models, including tests designed ... neuron formation and the formation of connections between ... Inhibition of neurodifferentiation and synapse formation by environmental ...
Breaking Biology Technology:Sate-of-the-Art Yuma Regional Cancer Center Officially Opens 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 3UMD Researchers Bridge Gap between Microelectronics, Biological Systems 4RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 2RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 3RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 4RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 5U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 2U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 3
... 10 Varian, Inc.,(NasdaqGS: VARI) announced the release ... applications involving liquid-state samples. The,OneNMR Probe product line ... a single probe rather than switching probes for,different ... and,research chemists performing a broad range of common ...
... TOKYO, and REDWOOD CITY, Calif., March 10, Otsuka ... PDLI ) today announced the closing of ... PDL,s,rights to IV Busulfex(R) (busulfan), including trademarks, patents,intellectual ... inventory,value., IV Busulfex is an oncologic product ...
... (Amex: PTN ) announced today the completion ... novel, long-acting natriuretic peptide,receptor A (NPRA) agonist under ... (CHF). The Phase I trial was a,randomized, double-blind, ... volunteers who received the medication or placebo,subcutaneously. The ...
Cached Biology Technology:Double Resonance Probe for Liquid State NMR Applications From Varian, Inc. Increases Productivity for Routine Analyses 2Otsuka Pharmaceutical and PDL BioPharma Close Sale of IV Busulfex 2Otsuka Pharmaceutical and PDL BioPharma Close Sale of IV Busulfex 3Otsuka Pharmaceutical and PDL BioPharma Close Sale of IV Busulfex 4Palatin Technologies, Inc. Reports Positive Results of a Phase I Clinical Study With PL-3994 for the Treatment of Congestive Heart Failure 2Palatin Technologies, Inc. Reports Positive Results of a Phase I Clinical Study With PL-3994 for the Treatment of Congestive Heart Failure 3Palatin Technologies, Inc. Reports Positive Results of a Phase I Clinical Study With PL-3994 for the Treatment of Congestive Heart Failure 4
APO-BrdU™ TUNEL Assay Kit *with Alexa Fluor® 488 anti-BrdU* *60 assays*...
The FlowTACS Apoptosis Detection Kit is designed specifically for in situdetection of apoptotic...
Recombinant Rat PTX2/SAP...
Request Info...
Biology Products: