Navigation Links
Social stress and the inflamed brain
Date:4/21/2013

BOSTON Depression is the leading cause of disability with more than 350 million people globally affected by this disease. In addition to debilitating consequences on mental health, depression predisposes an individual to physiological disease such as heart disease, and conversely heart disease increases the risk of depression. According to the World Health Organization by the year 2020 heart disease and depression will be the number one and number two leading causes of disability in developed countries. While the co-occurrence of these disorders is well recognized, an understanding of the underlying mechanisms that lead to this relationship are lacking.

Dr. Susan K. Wood, a Research Associate at the Children's Hospital of Philadelphia, investigates brain-related biomarkers for depression-heart disease comorbidity. She uses a rodent model of social stress likened to bullying in people that she has found to produce depressive-like behaviors and dysfunctional cardiovascular changes in a susceptible subset of rodents. Her previous work highlighted a role for the stress-related neurohormone corticotropin-releasing factor in rendering an individual vulnerable to stress-induced depression and heart disease. Intrigued by what other biomarkers may be distinct her latest study is the first to identify gene and protein expression differences in the brains of rodents that are either vulnerable or resilient to developing stress-induced depressive-like behaviors and cardiovascular dysfunction.

The study, conducted in male rats, compared expression of 88 genes involved in signaling within the brain between socially stressed and non-stressed rats. It revealed more than 35 genes in stressed rats that had altered expression compared with non-stressed controls. Many of the genes that were differentially expressed were related to inflammation. Follow-up studies measuring protein levels revealed that Interleukin-1β and Monocyte chemotactic protein-1, inflammatory markers known to play a role in depression and heart disease, were suppressed in the brains of the resilient subset of rats and Interleukin-1β was increased in the vulnerable group. Dr. Wood measured the gene and protein levels under resting conditions 24 hours after just 5 daily 30-minute exposures to social stress.

The identification of factors in the brain that distinguish susceptibility and resiliency to depression and heart disease comorbidity would be a major advance in predicting, preventing and treating these disorders. Dr. Wood is continuing these studies as an Assistant Professor at the University of South Carolina School of Medicine with the hope that these findings will uncover new targets to treat the mind and body.

Her findings will be presented April 21st, 2013 during Experimental Biology 2013 in Boston, MA.


'/>"/>

Contact: Jim Bernstein
jbernstein@aspet.org
301-646-3259
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Do I know you? Memory patterns help us recall the social webs we weave, finds new Cornell study
2. Social bees mark dangerous flowers with chemical signals
3. Socially isolated rats are more vulnerable to addiction, report researchers
4. The benefits of social grooming
5. They hunt, they kill, they cheat: Single-celled algae shed light on social lives of microbes
6. Social synchronicity
7. German Research Foundation to fund globally unique twin study on social inequality
8. Learning whos the top dog: Study reveals how the brain stores information about social rank
9. Social factors trump genetic forces in forging friendships, CU-led study finds
10. Hermit crabs socialize to evict their neighbors
11. Academia should fulfill social contract by supporting bioscience startups, case study says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
(Date:6/2/2016)...   The Weather Company , an IBM Business (NYSE: ... capability in which consumers will be able to interact with ... via voice or text and receive relevant information about the ... Marketers have long sought an advertising solution that can create ... relevant and valuable; and can scale across millions of interactions ...
(Date:5/24/2016)... care by providing unparalleled technology to leaders of the medical imaging industry.  As such, ... to the range of products distributed by Ampronix. Photo - http://photos.prnewswire.com/prnh/20160524/371420 ... ... ... With ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... pleased to announce the launch of their brand, UP4™ Probiotics, into Target stores ... 35 years, is proud to add Target to its list of well-respected retailers. ...
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
(Date:6/23/2016)... 2016  The Prostate Cancer Foundation (PCF) is pleased to announce ... cures for prostate cancer. Members of the Class of 2016 were selected from ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission ... hardware projects are designed, built and brought to market. , The Design Lab ...
Breaking Biology Technology: