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Sociable receptors: In pairs, in groups or in a crowd
Date:2/5/2014

or of the study. "In fact, it is not the size of each individual group that matters, but the composition of the entire population of groups."

The more trimers and tetramers and the fewer dimers present in the cell membrane, the stronger the repulsion signal. In contrast, a higher abundance of dimers and a smaller number of multimers produce a weaker reaction or none at all. "Thanks to this mechanism, a cell can grade its response from forcing another cell to make a U-turn to simply guiding it past at close range", Rdiger Klein says. This is an important step in understanding how migrating and growing cells navigate, and why this guidance system breaks down in some diseases.


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Contact: Stefanie Merker
merker@neuro.mpg.de
49-898-578-3514
Max-Planck-Gesellschaft
Source:Eurekalert  

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