Navigation Links
Sociable receptors: In pairs, in groups or in a crowd
Date:2/5/2014

Max Planck Institute of Neurobiology. He has been studying the language of the cells for years together with colleagues in his department. Their research focuses on the so-called Eph receptors and their ephrin ligands.

Cell communication via ephrin/Eph receptors comes into play in most encounters between cells. As a result of this communication, one cell usually repels the other, which continues to grow in another direction. Many such instances of interaction guide the cell to the right place. The guidance system itself the ephrins and Eph receptors are found on the cell surface. When the ephrin and the Eph receptor of two opposing cells meet, they form an ephrin/Eph complex. This triggers cellular processes in one or both of the cells, which eventually cause the detachment of the ephrin/Eph complex and the repulsion of the two cells from one another.

"Many receptor systems have developed a security mechanism to prevent false alarms from triggering the cellular processes", explains Rdiger Klein. "A signal is only transmitted to the cell if two receptor/ligand pairs form a dimer." However, in the case of ephrins and Eph receptors, things are different. Ephrin/Eph complexes form dimers, but often also larger groups on the cell membranes. Scientists were previously not sure how this affects repulsion and repulsive signalling strength.

The neurobiologists in Martinsried and their colleagues from the Max Planck Institute of Molecular Physiology in Dortmund have now been able to artificially trigger and study the formation of groups of Eph receptors in cell culture. The results show that the otherwise usual dimers are inactive when made up of Eph receptors. Only trimers and tetramers triggered the signals that caused cell repulsion. However, the scientists' working hypothesis that a larger group would trigger a stronger signal turned out to be too simple. "It took us quite some time to figure out the system", says Andreas Schaupp, first auth
'/>"/>

Contact: Stefanie Merker
merker@neuro.mpg.de
49-898-578-3514
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Different neuronal groups govern right-left alternation when walking
2. OU research groups awarded NSF grants to expand research and training in science and engineering
3. Shark rules need teeth, groups tell IUCN
4. Video-gaming fish play out the advantages of groups
5. Environmental groups should pool efforts to reach the public
6. 2 distinguishable gene groups detected: 1 normal and 1 problematic
7. Unleashing the power of the crowd
8. Carnegie Mellon researchers develop artificial cells to study molecular crowding and gene expression
9. CU-Boulder helps tap crowds to digitize museum records of bugs and plants
10. Crowdsourcing to kickstart comeback from ash dieback
11. Study sheds light on how cells transport materials along crowded intercellular highways
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sociable receptors: In pairs, in groups or in a crowd
(Date:12/17/2014)... 2014  Automation is fundamentally transforming the travel ... at international borders. Over the past decade, ePassports, ... veteran travelers to self process through border control ... at an increasing number of airports, seaports, and ... According to Maxine Most , Principal at ...
(Date:12/11/2014)... --Research and Markets , ... ) has announced the addition of the ... to their offering. One major ... technology. With continuous advances in technology, it is ... standard that meets the needs and expectations of ...
(Date:12/11/2014)... 2014  That blood pressure plays a role in human ... the medical term for high blood pressure – was first ... inflatable cuff that,s used in measuring blood pressure was invented ... new about hypertension, its triggers and its effects. In fact, ... and the best ways to treat it. For ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... release is available in German . ... plant introductions than extinctions, plant communities of many European ... occurring more frequently, whereas rare species are becoming extinct. ... becoming increasingly similar, but also the phylogenetic relations between ...
... The sequences of nonsense DNA that interrupt genes could ... than previously thought, according to a recent Science report ... biologists. Their study of the model organism ... demonstrate the colonization of a single lineage by "introns," ...
... 10, 2009 Arup K. SenGupta, Ph.D., a professor ... in Bethlehem, Pa., has been chosen to receive a ... the American Chemical Society, is given to individuals who ... health through their work in the chemical and related ...
Cached Biology News:Europe's flora is becoming impoverished 2Europe's flora is becoming impoverished 3Introns: A mystery renewed 2Introns: A mystery renewed 3Introns: A mystery renewed 4
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... Inc. (Nasdaq: NPSP ) announced today that ... and chief,executive officer-elect is scheduled to present at ... Miami on Wednesday, March,19, 2008 at 3:15 p.m. ... live,webcast with a replay available approximately 24 hours ...
... /PRNewswire-FirstCall/ - AEterna Zentaris Inc.,(NASDAQ: AEZS ... focused on,endocrine therapy and oncology, today announced ... Senior Vice President, Administrative & Legal,Affairs and ... position of,Vice President and Chief Financial Officer ...
... 29 Alfacell Corporation,(Nasdaq: ACEL ) today announced ... 11 a.m. EST on Friday, March 7. During the ... Kenyon, chief operating,officer and chief financial officer, will present ... quarter 2008, ended January 31,2008., To participate in ...
Cached Biology Technology:AEterna Zentaris Announces the Departure of SVP, Administrative and Legal Affairs 2Alfacell to Host Fiscal Second Quarter 2008 Financial Results Conference Call and Webcast 2
... Gene silencing experiments often call for ... NeoFX Transfection Agent refines siRNA transfection ... NeoFXs lipid-based formulation can be used ... they are subcultured without increased ...
Kit for BASE20/50 dual control unit, includes mounting plate, HOLDER50T, HEATERPAD50, SRTDX temperature probe(s)....
... CHEMICON® CaspaTag™ Pan-Caspase In Situ Assay Kit ... active caspases in cells undergoing apoptosis. The ... for use in diagnostic or therapeutic procedures. ... use a novel approach to detect active ...
... nM is available for in vivo ... in: Z. Hassani, G.-F. Lemkine, P. Erbacher, ... B.-A. Demeneix. Lipid-mediated siRNA delivery down regulates ... at picomolar levels. J. Gene Med., 2005, ...
Biology Products: