Navigation Links
Snoozing worms help Penn researchers explain the evolution of sleep
Date:1/11/2008

PHILADELPHIA The roundworm C. elegans, a staple of laboratory research, may be key in unlocking one of the central biological mysteries: why we sleep. Researchers at the University of Pennsylvania School of Medicine report in this weeks advanced online edition of Nature that the round worm has a sleep-like state, joining most of the animal kingdom in displaying this physiology. This research has implications for explaining the evolution and purpose of sleep and sleep-like states in animals.

In addition, genetic work associated with the study provides new prospects for the use of C. elegans to identify sleep-regulatory genes and drug targets for sleep disorders.

First author David M. Raizen, MD, PhD, Assistant Professor of Neurology, in collaboration with other researchers at the Penn Center for Sleep, showed that there is a period of behavioral quiescence during the worms development called lethargus that has sleep-like properties. Just as humans are less responsive during sleep, so is the worm during lethargus, explains Raizen. And, just as humans fall asleep faster and sleep deeper following sleep deprivation, so does the worm.

By demonstrating that worms sleep, Raizen and colleagues have not only demonstrated the ubiquity of sleep in nature, but also propose a compelling hypothesis for the purpose for sleep.

Because the time of lethargus coincides with a time in the round worms life cycle when synaptic changes occur in the nervous system, they propose that sleep is a state required for nervous system plasticity. In other words, in order for the nervous system to grow and change, there must be down time of active behavior. Other researchers at Penn have shown that, in mammals, synaptic changes occur during sleep and that deprivation of sleep results in a disruption of these synaptic changes.

In addition, the research team used C. elegans as a model system to identify a gene that regulates sleep. This
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scientists alter sexual orientation in worms
2. Drug commonly used to treat bipolar disorder dramatically increases lifespan in worms
3. Worms take the sniff test to reveal sex differences in brain
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. U of MN researchers discover noninvasive diagnostic tool for brain diseases
9. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
10. Researchers discover new strategies for antibiotic resistance
11. Researchers find new taste in fruit flies: carbonated water
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Snoozing worms help Penn researchers explain the evolution of sleep
(Date:4/16/2014)... of the Physical Biosciences Division of Lawrence Berkeley ... is recognized as a leading authority on the ... and their application to systems and synthetic biology, ... the 2013 Ernest Orlando Lawrence Award by U.S. ... the Department of Energy (DOE),s highest scientific honor, ...
(Date:4/16/2014)... or to conquer the world? Surprisingly, bacteria also ... in Munich have now shown how these organisms ... , The bacterium Bacillus subtilis is ... on agar surfaces by means of flagella. Alternatively, ... the bacteria proliferate most effectively in this stationary ...
(Date:4/16/2014)... Prechtl, Leo Heim and their colleagues at the University ... method of generating hydrogen using water and formaldehyde. The ... when it comes to fuel cell technologies. The results ... using water and formaldehyde", have recently been published in ... applications, the new approach can be used to recycle ...
Breaking Biology News(10 mins):Berkeley Lab's Adam Arkin wins 2013 Lawrence Award 2Berkeley Lab's Adam Arkin wins 2013 Lawrence Award 3Theoretical biophysics: Adventurous bacteria 2
... bats can deform the shapes of their ears in a way ... of a second, these bats are able to change their outer ... Mller , associate professor of mechanical engineering at Virginia Tech. ... that is appearing this week in Physical Review Letters ...
... This release is available in German . ... Trojan" software for the online monitoring of telecommunication between ... decisions provokes public disapproval. However, as a recent experimental ... components of our social repertoire. Human beings show a ...
... valves that link the lymphatic and blood systems were first ... those valves form and identified a gene that is critical ... led by Guillermo Oliver, Ph.D., a member of the St. ... and maintenance of the entire lymphatic vasculature. The lymphatic vasculature ...
Cached Biology News:Bats show ability to change their ear shapes, making their hearing more flexible 2Bats show ability to change their ear shapes, making their hearing more flexible 3Punishment of egoistic behavior is not rewarded 2Punishment of egoistic behavior is not rewarded 3Story of lymphatic system expands to include chapter on valve formation 2
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... thing for a dictator to control a relative handful ... another for a totalitarian regime to block information that ... , ,Perhaps that explains why some global web-o-crats are ... from its American roots and substitute United Nations-style regulation, ...
... position in stem-cell research is strong, there are pitfalls and ... its leading position, according to UW-Madison stem cell researcher ... to assist with its stem-cell work, spoke this week at ... of the Wisconsin Technology Council, about the current state of ...
... latest business venture of Mike Strand in Eau Claire ... competition, has landed $250,000 from the Chippewa Valley ... has a plan to put video screens showing advertising ... the statewide business-plan competition finals, it won the emerging ...
Cached Biology Technology:Democracy and the Net - How American ideals are quietly influencing the world 2Democracy and the Net - How American ideals are quietly influencing the world 3Competition for stem cell research is fierce 2Competition for stem cell research is fierce 3
... Agencourt offers quick turnaround sequencing of ... copy and high copy plasmids. Agencourt's world-class, ... million Phred20 bases per day. The ... Sequencing service are 24 48 hour ...
Great for biotinylating DNA/RNA probes...
...
...
Biology Products: