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'Snooze button' on biological clocks improves cell adaptability
Date:2/17/2013

k down in the algae, but it did have a more subtle, but potentially as profound effect: It significantly reduced cell survival at certain temperatures.

"Xu figured that the biological clock with optimized codons might work better at lower temperatures and it did," Johnson said. However the substitution also modified the biological clock so it ran with a longer, 30-hour period. When forced to operate in a 24-hour daily light/dark cycles, the bacteria with the optimized clock grew significantly slower than "wild-type" cells. "In cyanobacteria, it's as if writing speed changes the meaning," said Rokas.

The potential importance of changes in synonymous codon usage in adapting to environmental factors is magnified by the fact that they can influence the operation of biological clocks, which function as a key adaptation to daily environmental rhythms. Biological clocks control and influence dozens of different basic biological processes, including sleeping and feeding patterns, core body temperature, brain activity, hormone production and cell regeneration.

"It is now clear that variations in codon usage is a fundamental and underappreciated form of gene regulation," said Rokas.

Recognition of the importance of this process has a number of potential applications in biotechnology. For example, "it should be possible to improve the ability of algae to robustly express biofuel-producing proteins from other organisms by optimizing the codons that they use," Johnson said.


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Contact: David Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
Source:Eurekalert

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