Navigation Links
'Smothered' genes combine with mutations to yield poor outcome in cancer patients
Date:7/15/2008

ups and interferes with the gene's normal protein production, setting the stage for a lethal cancer.

Some 189 mutated genes in breast and colon cancers, previously identified by a Kimmel Cancer Center research team, were screened for methylation by Baylin's group. They found 36 genes that were infrequently mutated in cancer, but were "hyper"methylated, often in both breast and colon cancers. After reviewing samples from 30 breast and 20 colorectal cancer patients as well as information from public microarray databases, the researchers found 18 of these genes that were strongly linked to poor outcome of patients with tumors carrying these changes.

For most of the genes, the researchers were able to reverse their epigenetic change and reactivate them in test tubes by stripping off excess methyl groups. This suggests that new treatments designed to reverse hypermethylation could be a simpler and more practical approach to treating cancer than strategies that attempt to replace, deactivate or compensate for mutated genes, according to Baylin.

Baylin also believes that the methlylated genes identified in this study could be inactivated in a broader range of cancers as well. That means the current findings could be extended to other cancers, improving the ability of physicians to predict the course of additional types of tumors, he says.

"We've learned from this study that we must include both genetic and epigenetic changes when we do future microarray analyses to increase our understanding of the genetic basis of cancer," Baylin says. "Such information will provide new details about why cancers start and help us identify which cancers will be particularly aggressive in our patients."


'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists discover key patterns in the packaging of genes
2. The first autism disease genes
3. Researchers reveal types of genes necessary for brain development
4. UT Southwestern researchers identify new targets for RNAs that regulate genes
5. Texas A&M researchers develop tool to study complex clusters of genes
6. New oral angiogenesis inhibitor offers potential nontoxic therapy for a wide range of cancers
7. Scientists discover DNA knot keeps viral genes tightly corked inside shell
8. Brucella abortus S19 genome sequenced; points toward virulence genes
9. At Boston symposium, NARSAD researchers report on genes and family traits
10. New technique allows targeted inactivation of genes in research model
11. New cheaper method for mapping disease genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... linked to dandruff, eczema and other itchy, flaky maladies ... global reachesincluding Hawaiian coral reefs and the extreme environments ... review in the scientific journal PLOS Pathogens ... of the genus Malassezia in light of ... around the world. , University of Hawai,i at Mānoa ...
(Date:8/21/2014)... Juliane Mller the Fram Strait is a key region in ... passage between Greenland and Svalbard warm Atlantic water flows to ... side cold Arctic water masses and sea ice push their ... considerable portion of the Atlantic water cools here on its ... circulation of the water caused in this manner drives the ...
(Date:8/21/2014)... RUSTON, La. A team of researchers ... innovative method for using affordable, consumer-grade 3D ... implants that can contain antibacterial and chemotherapeutic ... team comprised of doctoral students and research ... nanosystems engineering programs collaborated to create filament ...
Breaking Biology News(10 mins):From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3
... builder. Using a bottom-up approach, nature takes tiny atoms ... silicon and even table salt. In all of them, ... and arrangement of atoms within the crystalline lattice. ... learned how to top nature by building crystalline materials ...
... ARLINGTON, Va.R&D Magazine honored Office of Naval Research ... "R&D 100" award on Oct. 13 for the development ... The special high-tech surface technology, HybridSil Fire/Blast, acts ... type of surface, making it blast-, ballistic- and fire-resistant. ...
... 2011 Researchers have shown for the first time that ... in cats. The research was conducted at the WALTHAM Centre ... such as WHISKAS and ROYAL CANIN. The research demonstrated ... daily water intake to a level that cannot be achieved ...
Cached Biology News:Emulating -- and surpassing -- nature 2Emulating -- and surpassing -- nature 3Spray-on protective coating wins 'R&D 100' Award 2
(Date:8/21/2014)... His Majesty Willem-Alexander, King of the Netherlands ... His Majesty Willem-Alexander, King of the Netherlands, has announced ... POET-DSM Advanced Biofuels’ Project LIBERTY cellulosic ethanol plant in ... will take part in the Grand Opening Ceremony to ... p.m. and tour the plant. POET-DSM is a joint ...
(Date:8/21/2014)... , Aug. 21, 2014  Decision Resources ... Brazil and Mexico ... uptake of several newly approved agents, the anticipated ... indication and the launch of emerging biologics will ... In particular, the emerging IL-5 inhibitors will introduce ...
(Date:8/21/2014)... -- China Cord Blood Corporation (NYSE: CO ) ... results for the first quarter of fiscal year 2015 ... the US.  The Company will host ... August 29, 2014 to discuss its financial performance and ... followed by a question and answer session.  Interested parties ...
(Date:8/21/2014)... 2014 Ontotext S4 , The ... Ontotext . Now the same enterprise hardened text ... and unstructured data is available to start-ups and mid-size ... technology. Organizations that do not have resources to evaluate ... use S4 since there is no need for on ...
Breaking Biology Technology:His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4
... WEST BRIDGEWATER, Mass., Aug. 30 Pressure,BioSciences, ... announced that it has been,issued its first ... "Pressure-Mediated Binding of Biomolecular Complexes" (Number,2,259,318), this ... pressure,cycling technology (PCT) patents previously issued in ...
... ITMN ) today announced that Daniel G. Welch, ... the Thomas Weisel,Healthcare Conference in Boston on September 5, ... at the Bear Stearns 20th Annual Healthcare,Conference in New ... EDT. To access a live audio webcast of ...
... 30 VaxGen,Inc. (Pink Sheets: VXGN) announced today ... Commission (SEC) its Annual Report on Form 10-K ... Reports on Form 10-Q for the,first three quarters ... the link titled,"SEC Filings" in the Investor Relations ...
Cached Biology Technology:Pressure BioSciences, Inc. Issued First Patent in Canada 2Pressure BioSciences, Inc. Issued First Patent in Canada 3InterMune to Present at Thomas Weisel and Bear Stearns Healthcare Conferences 2VaxGen Files 2006 Financial Statements and Provides Cash Update 2
... Purity is >95%NEN Radiolabeled Ligands\n\nReceptor-related research has ... of new radiolabeled ligands selected to keep ... wide range of products and services for ... 400 state-of-the-art radioligands. If you do not ...
Request Info...
... (patent pending) was developed using a protein engineering ... DNA binding pocket of wild-type DNase I. These ... for DNA. The result is a versatile enzyme ... and an ability to maintain at least 50% ...
Request Info...
Biology Products: