Navigation Links
Smoking turns on genes -- permanently
Date:8/29/2007

Smoking tobacco is no longer considered sexy, but it may prove a permanent turn on for some genes. Research published today in the online open access journal BMC Genomics could help explain why former smokers are still more susceptible to lung cancer than those who have never smoked.

A Canadian team led by Wan L Lam and Stephen Lam from the BC Cancer Agency, took samples from the lungs of 24 current and former smokers, as well as from non-smokers who have never smoked. They used these lung samples to create libraries using a technique called serial analysis of gene expression (SAGE), which helps to identify patterns of gene activity.

Only about a fifth of the genes in a cell are switched on at any given time, but environmental changes such as smoking lead to changes in gene activity. The researchers found changes that were irreversible, and some changes that were reversed by stopping smoking. The reversible genes were particularly involved in xenobiotic functions (managing chemicals not produced in the body), nucleotide metabolism and mucus secretion. Some DNA repair genes are irreversibly damaged by smoking, and smoking also switched off genes that help combat lung cancer development.

The researchers identified a number of genes not previously associated with smoking that are switched on in active smokers. One example is CABYR, a gene involved in helping sperm to swim and associated with brain tumours, which may have a ciliary function. The team also further investigated changes in genes involved in airway repair and regeneration, and within this group identified genes that fell into three categories following cessation of smoking: reversible (TFF3, encoding a structural component of mucus; CABYR, in it's newly discovered bronchial role), partially reversible (MUC5AC, a mucin gene) and irreversible (GSK3B, involved in COX2 regulation). These findings were tested against a second cohort of current, former and non-smokers.


'/>"/>

Contact: Charlotte Webber
press@biomedcentral.com
44-020-763-19980
BioMed Central
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research shows smoking adds a decade to reproductive age of IVF patients
2. OHSU research shows vitamin C counteracts some negative impacts of smoking on unborn babies
3. Indias smoking gun: Dino-killing eruptions
4. Smoking damages key regulatory enzyme in the lung
5. Alcoholism, smoking and genetics among Plains American Indians
6. Both alcoholism and chronic smoking can damage the brains prefrontal cortex
7. Researchers test new way to quit smoking
8. Blood test predicts success of quitting smoking using the nicotine patch
9. Quitting smoking improves lung function considerably
10. Smoking changes brain chemistry
11. Cigarette smoking impedes tendon-to-bone healing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Nine researchers from Beth Israel Deaconess Medical Center (BIDMC ... World,s Most Influential Scientific Minds 2014," a comprehensive ... a web resource for science metrics and research performance ... the most influential "are performing and publishing work that ... their science," according to a Thomson Reuters statement. Researchers ...
(Date:8/21/2014)... heard of the water window? It consists of radiations ... not absorbed by the water in biological tissues. New ... coherent radiations within the water window. These could be ... high-contrast image of the biological samples or to be ... identifies the physical mechanism needed to efficiently generate the ...
(Date:8/21/2014)... feeding tube connectors, designed by an international standards process, ... , According to an invited review published in the ... ( NCP ), the official journal of the American ... connectors will greatly reduce the occurrence of misconnection that ... Small-bore connectors, which are used to join medical devices, ...
Breaking Biology News(10 mins):BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3Water window imaging opportunity 2New feeding tube connectors will improve patient safety 2
... are under attack. Since 2006, more than a million have ... there has not been enough evidence to implicate the suspectuntil ... Geomyces destructans is the causal agent of White-nose Syndrome (WNS), ... is coauthored by Justin Boyles, a post-doctoral research associate in ...
... Dalhousie University in Nova Scotia have identified a key ... growth if their findings are confirmed. In ... journal of the American Association for Cancer Research, lead ... Biochemistry and Molecular Biology and Pathology, and Canada Research ...
... alphabet expanded. Scientists discovered that an extra letter or ... cells and brain cells. Now, researchers at Emory ... by that letter in the brains of mice, observing ... during development and aging. Those patterns, stable or ...
Cached Biology News:UT scientist helps confirm link between fungus and bat epidemic 2Key driver of metastasis identified 2Patterns of new DNA letter in brain suggest distinct function 2
(Date:8/21/2014)... 21, 2014 2014 Deep ... is a professional and in-depth research report ... provides basic Seaweed Fertilizer information, including Seaweed ... structure as well as industry overview. This ... domestic market as well as global industry ...
(Date:8/21/2014)... 21, 2014  Decision Resources Group finds that ... and Mexico currently ... newly approved agents, the anticipated label extension of ... launch of emerging biologics will substantially increase the ... emerging IL-5 inhibitors will introduce a new dynamic to ...
(Date:8/21/2014)... NJ (PRWEB) August 21, 2014 ... personal selling optimization technology and services for Life ... of “Grading Pharma’s Use of New Commercial Sales ... Measurement & Analytics. , The article examines some ... yield that are being tested in the pharmaceutical ...
(Date:8/20/2014)... 2014 Clintrax Global, Inc., a worldwide ... Raleigh, NC , recently announced the ... President of Administration. As Vice ... processes, including their alignment with company objectives and ... as an HR executive, specializing in needs assessments, ...
Breaking Biology Technology:Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2Clintrax Global, Inc. Announces Addition to Executive Team 2
... EMERYVILLE, Calif., Jan. 2 Onyx,Pharmaceuticals, Inc. (Nasdaq: ... present,at the JPMorgan Healthcare Conference on Monday, January ... access a live webcast of the,presentation at:, ... listeners log on 15 minutes early in order ...
... - Oncolytics Biotech Inc.,("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced ... has filed a protocol with the U.S. ... 1/2 clinical trial for patients with,metastatic ovarian, ... and intraperitoneal administration of REOLYSIN(R), Oncolytics,proprietary formulation ...
... LOS GATOS, Calif., Dec. 31 Three ... announced that it has received 510(k) clearance,from ... for its WorkstationOne(TM),Breast Imaging Workstation. WorkstationOne is ... mammography images, and was developed with,the goal ...
Cached Biology Technology:Oncolytics Biotech Inc. Announces Filing of Phase 1/2 Clinical Trial with REOLYSIN(R) 2
Recombinant Feline IFN-alpha...
Rabbit polyclonal to Presenilin 1, prediluted ( Abpromise for all tested applications). entrezGeneID: 5663 SwissProtID: P49768...
Mouse monoclonal [LPL4A.1] to Plastin L ( Abpromise for all tested applications). SwissProtID: P13796...
... MaV203 Competent Yeast Cells are designed ... (Figure 1). S. cerevisiae strain MaV203 contains ... genes for use with GAL4-based two-hybrid systems. ... mutations for selection of ProQuest bait and ...
Biology Products: