Navigation Links
Smoking turns on genes -- permanently
Date:8/29/2007

Smoking tobacco is no longer considered sexy, but it may prove a permanent turn on for some genes. Research published today in the online open access journal BMC Genomics could help explain why former smokers are still more susceptible to lung cancer than those who have never smoked.

A Canadian team led by Wan L Lam and Stephen Lam from the BC Cancer Agency, took samples from the lungs of 24 current and former smokers, as well as from non-smokers who have never smoked. They used these lung samples to create libraries using a technique called serial analysis of gene expression (SAGE), which helps to identify patterns of gene activity.

Only about a fifth of the genes in a cell are switched on at any given time, but environmental changes such as smoking lead to changes in gene activity. The researchers found changes that were irreversible, and some changes that were reversed by stopping smoking. The reversible genes were particularly involved in xenobiotic functions (managing chemicals not produced in the body), nucleotide metabolism and mucus secretion. Some DNA repair genes are irreversibly damaged by smoking, and smoking also switched off genes that help combat lung cancer development.

The researchers identified a number of genes not previously associated with smoking that are switched on in active smokers. One example is CABYR, a gene involved in helping sperm to swim and associated with brain tumours, which may have a ciliary function. The team also further investigated changes in genes involved in airway repair and regeneration, and within this group identified genes that fell into three categories following cessation of smoking: reversible (TFF3, encoding a structural component of mucus; CABYR, in it's newly discovered bronchial role), partially reversible (MUC5AC, a mucin gene) and irreversible (GSK3B, involved in COX2 regulation). These findings were tested against a second cohort of current, former and non-smokers.


'/>"/>

Contact: Charlotte Webber
press@biomedcentral.com
44-020-763-19980
BioMed Central
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research shows smoking adds a decade to reproductive age of IVF patients
2. OHSU research shows vitamin C counteracts some negative impacts of smoking on unborn babies
3. Indias smoking gun: Dino-killing eruptions
4. Smoking damages key regulatory enzyme in the lung
5. Alcoholism, smoking and genetics among Plains American Indians
6. Both alcoholism and chronic smoking can damage the brains prefrontal cortex
7. Researchers test new way to quit smoking
8. Blood test predicts success of quitting smoking using the nicotine patch
9. Quitting smoking improves lung function considerably
10. Smoking changes brain chemistry
11. Cigarette smoking impedes tendon-to-bone healing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... PLEASANTON, Calif. , July 9, 2015 /PRNewswire/ ... tools, today announcing its acquisition of Avid Nano. ... dynamic light scattering (DLS) systems.    ... world,s smallest, fastest and easiest to use protein ... system that measures a protein,s hydrodynamic size, size ...
(Date:7/8/2015)... 2015  Trovagene, Inc. (NASDAQ: TROV ), ... the launch of a study that aims to ... (PCM) technology for predicting response to treatment in ... of the novel immunotherapy agents Yervoy® (ipilumumab), a ... The 50-patient study will be led by researchers ...
(Date:7/7/2015)... , July 7, 2015 NXT-ID, Inc. (NASDAQ: ... on the growing mobile commerce market announces a revised version of ... week. The commercial will air on CNBC in New ... Angeles and San Francisco metro ... commercial focuses on Wocket,s ability to replace all the cards in ...
Breaking Biology News(10 mins):Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 3
... D. Johnson, PhD, and Shinya Yamanaka, MD, PhD, have been ... for their excellence in original scientific research. It is one ... in the United States. They join 70 other ... today. UCSF now has 40 current faculty members in ...
... another piece to the obesity puzzle, showing how and why ... of the brain contributes to weight gain. This research appeared ... Elson and his team in the Institute,s Molecular Genetics Department ... genetically engineered to lack this protein, called protein tyrosine phosphatase ...
... (VC) funding in the Life Sciences sector, ... in terms of dollar investments during the first quarter ... "A Case for Cautious Optimism."   The report includes ... MoneyTree™ Report, based on data from Thomson Reuters . ...
Cached Biology News:UCSF scientists honored by National Academy of Sciences 2Weizmann Institute scientists discover: A protein that contributes to obesity 2Life Sciences Venture Capital Investment Level Rebounds in Q1 2011 but Deal Volume Declines, According to the MoneyTree Report 2Life Sciences Venture Capital Investment Level Rebounds in Q1 2011 but Deal Volume Declines, According to the MoneyTree Report 3Life Sciences Venture Capital Investment Level Rebounds in Q1 2011 but Deal Volume Declines, According to the MoneyTree Report 4
(Date:7/29/2015)... , July 29, 2015 US-Australian drug ... ) today confirmed it is committed to progressing its ... soon as practicable and to ensure the Company delivers ... Executive Officer, Iain Ross , said the Company ... the lead pre-clinical programs, discovery programs and academic partnerships ...
(Date:7/29/2015)... SAN FRANCISCO , July 29, 2015 /PRNewswire/ ... trialling mobile molecular testing for applications in food ... Ubiquitome,s hand-held, battery powered real-time PCR device, the ... the farm right through to the supermarket shelf ... world. This includes involvement in animal disease control ...
(Date:7/29/2015)... -- AmnioChor Inc., an early stage biotech startup based on ... that the Musculoskeletal Transplant Foundation of Edison ... seed round of development of the proprietary AmnioCept™ product ... AmnioChor,s technology allows cryopreservation of the amniotic membrane ... within those tissues. Amnion is a well-established source of ...
(Date:7/29/2015)... ... July 29, 2015 , ... The third Medical Innovation Impact Index (MI3) ... in particular, drug/device combinations. The current system received a score of 0 (range -10 ... Centered Innovation (iPCI) of Fairleigh Dickinson University’s ( FDU ) Rothman Institute of ...
Breaking Biology Technology:Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2The Musculoskeletal Transplant Foundation Agrees to Invest in AmnioChor 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 3
... Introduction , ... ® expression data. These statistical algorithms, created in ... typical distribution of data found in microarray experiments. The ... optimized to accommodate advancements in array and probe selection ...
... , Chromatography and Mass Spectrometry Application Note ... Ph.D, , Thermo Electron Corporation, ... Introduction , The Deferred ... of monitoring the reliability of process chromatography. The DS consists of an injection ...
... Spectrometry Application Note , Key Words Sensitivity ... Xiaoying Xu 1 , Gary Paul 2 , Qiao Zhou1, ... 1 Department of Drug Metabolism and ... NJ, USA , Overview , ...
Cached Biology Technology:New statistical algorithms for Monitoring Gene Expression on GeneChip® Probe Arrays 2New statistical algorithms for Monitoring Gene Expression on GeneChip® Probe Arrays 3New statistical algorithms for Monitoring Gene Expression on GeneChip® Probe Arrays 4New statistical algorithms for Monitoring Gene Expression on GeneChip® Probe Arrays 5New statistical algorithms for Monitoring Gene Expression on GeneChip® Probe Arrays 6Accurate Evaluation of the Finnigan Surveyor Autosampler Performance using a Deferred Standard 2Accurate Evaluation of the Finnigan Surveyor Autosampler Performance using a Deferred Standard 3Accurate Evaluation of the Finnigan Surveyor Autosampler Performance using a Deferred Standard 4Increased Analyte Sensitivity through the Utility of Enhanced Mass-Resolution on the FinniganTSQ Quantum Discovery 2Increased Analyte Sensitivity through the Utility of Enhanced Mass-Resolution on the FinniganTSQ Quantum Discovery 3Increased Analyte Sensitivity through the Utility of Enhanced Mass-Resolution on the FinniganTSQ Quantum Discovery 4Increased Analyte Sensitivity through the Utility of Enhanced Mass-Resolution on the FinniganTSQ Quantum Discovery 5Increased Analyte Sensitivity through the Utility of Enhanced Mass-Resolution on the FinniganTSQ Quantum Discovery 6
SHEEP ANTI DEHYDROEPIANDROSTERONE...
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure Grade DAPI is greater than or equal to 98% pure by HPLC....
... et.al. (1997) • Contains short ... biochemistry & molecular biology, arranged ... Entries give details of biochemical ... which they are involved and ...
... • This book describes the basic ... preparing samples for protein transfer and ... bioluminescence-enhanced detection systems are also included. ... and characterization of glycoprotein carbohydrate chains ...
Biology Products: