Navigation Links
Smart orthopedic implants and self-fitting tissue scaffolding created by UMMS researchers
Date:4/5/2010

WORCESTER, Mass. Orthopedic surgeons are often hamstrung by less-than-ideal grafting material when performing surgeries for complex bone injuries resulting from trauma, aging or cancer. Conventional synthetic bone grafts are typically made of stiff polymers or brittle ceramics, and cannot readily conform to the complex and irregular shapes that often result from injury; in addition, they often require metallic fixation devices that require open surgeries to insert and remove. Ideally, a scaffolding graft would conform to complex shapes of an injury site, provide weight-bearing support, require less invasive surgical delivery, and ultimately disappear when no longer needed.

Using a nanoparticle core, Jie Song, PhD, assistant professor of orthopedics & physical rehabilitation and cell biology at the University of Massachusetts Medical School, and postdoctoral fellow Jianwen Xu, have fashioned a new type of tissue and bone scaffolding polymer that addresses a number of these long-standing limitations. Research published in the online Early Edition of Proceedings of the National Academy of Sciences, describes the development of a class of heat-activated smart materials that combine tissue-like properties and strength that are clinically safe to deploy and able to integrate with surrounding tissue.

The key feature of the new polymer is its heat-activated malleability and shape memory. Using CT scans and MRI images of the injury site, Song envisions physicians creating a polymer mold of the scaffolding needed to stabilize a skeletal injury site, in the lab, prior to surgery. Heat activated at a safe 50C, the smart polymer could then be reshaped to a more compressed form suitable for insertion in the body through a small, minimally invasive incision. Once at the injury site, the idea is to then thermally re-activate the polymer to cause it to revert to its original, pre-molded shape in seconds, according to Song.

In addition to providing mechanical stabilization to the skeletal structure, because the biodegradable material is similar to those used in dissolvable sutures, it can be safely reabsorbed by the body as it breaks down over time. Therefore, there is no need for a second surgery to remove the implant. Additionally, as the scaffolding degrades, the polymer provides a porous structure that promotes tissue growth and integration. At the same time, the polymer has the ability to deliver therapeutics to accelerate new bone growth and integration.

"Strong and resorbable smart implants could have paradigm-changing impact on a number of surgical interventions that currently rely on the use of more invasive and less effective metallic cages, fixators and stents," said Song. "From spinal fusion to alleviate chronic lower back pain, vertebroplasty for treating vertebral fractures to angioplasty for widening narrowed or obstructed blood vessels, there are tremendous clinical applications for smart polymers."

Song and colleagues are testing the safety and efficacy of the material in animal models, which they hope will pave the way for future clinical trials.


'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Related biology news :

1. Like little golden assassins, smart nanoparticles identify, target and kill cancer cells
2. Smart coating opens door to safer hip, knee and dental implants
3. Vidient SmartCatch Protecting Exit Lanes at Major UK Airport
4. NOAA deploys new smart buoy off Annapolis
5. WCC Smart Search & Match and Priv-ID Announce Global Collaboration
6. NSF Emerging Frontiers program supports development of smart materials based on study of fish
7. Spread your sperm the smart way
8. Cancer: The cost of being smarter than chimps?
9. Ultrasound imaging now possible with a smartphone
10. Intruder alert: Tel Aviv Universitys Smart Dew will find you!
11. Reducing CO2 through technology and smart growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/17/2016)...  AIC announces that it has just released a new white paper authored by ... plus high speed data transfer storage solutions. Photo - http://photos.prnewswire.com/prnh/20161116/440463 ... ... ... Setting up a high performance computing or HPC system can ...
(Date:11/14/2016)... CLARA, Calif. , Nov. 14, 2016 ... the biometric identification market, Frost & Sullivan ... Frost & Sullivan Award for Visionary Innovation ... player in the biometric identification market by ... multi-modal verification solution for instant, seamless, and ...
(Date:6/21/2016)... 2016 NuData Security announced today that Randy ... principal product architect and that Jon Cunningham ... development. Both will report directly to Christopher ... reflect NuData,s strategic growth in its product and ... demand and customer focus values. ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... TORONTO , Nov. 30, 2016 /PRNewswire/ - Portage ... Canadian Securities Exchange: PBT.U), is excited to announce ... company focused on developing preclinical ophthalmology assets through ... a potent anti-inflammatory created by Portage Pharmaceuticals Limited ... patients with ocular surface and anterior segment diseases. ...
(Date:11/30/2016)... , Nov. 30, 2016 /PRNewswire/ -  Equicare Health ... solutions, has been recognized as one of the top ... an annual international listing that distinguishes the top digital ... pushed a great step forward this year continually upgrading ... our own customer base and team," says Len ...
(Date:11/30/2016)... 2016   Merck , ein führendes ... einer Reihe von Vereinbarungen mit Evotec AG ... Screeningleistungen für Mercks Palette genetischer Reagenzien wie ... diese Bibliotheken in Kombination mit Evotecs Expertise ... zur Ermittlung und Erforschung neuer Arzneimitteltargets.    ...
(Date:11/30/2016)... ... November 30, 2016 , ... SSCI, the established leader in small-molecule cocrystal ... the latest FDA guidance on pharmaceutical cocrystals as drug substance . The ... , The event follows the successful November 15th event that took place in ...
Breaking Biology Technology: