Navigation Links
Small variations in genetic code can team up to have a bi
Date:5/2/2014

Scientists at USC have definitively demonstrated that large sets of variations in the genetic code that do not individually appear to have much effect can collectively produce significant changes in an organism's physical characteristics.

Studying the budding yeast Saccharomyces cerevisiae, USC's Matthew B. Taylor and Ian M. Ehrenreich found that the effects of these genetic variants can depend on four or more other variants in an individual's genome.

Most genetic analyses of heritable physical characteristics, including genome-wide association studies in human populations, focus on so-called "additive" variants that have effects that occur regardless of the organism's genetic background. Taylor and Ehrenreich, however, found that higher-order interactions of five or more places along the genome can have major impacts, and may help explain the so-called "missing heritability" problem, in which additive genetic variants do not entirely explain many inherited diseases and traits.

"Studies focused only on additive effects often explain just a fraction of the genetic basis of many traits. The question is, what are we missing?" said Ehrenreich, assistant professor of molecular biology at the USC Dornsife College of Letters, Arts and Sciences, and corresponding author of a paper on the study that was published by PLOS Genetics on May 1.

An alternative view of Taylor and Ehrenreich's findings is that genetic variants that have the potential to cause major changes in an organism's phenotype can be completely canceled out if they occur in the "wrong" genomic background.

"It's exciting to provide a characterized example of how genetic background can influence the effects of mutations. We hope that this will open the door for future studies to tease apart how these complex interactions happen," said Taylor, a PhD student in the Molecular and Computational Biology Section at USC.

Their work could impact g
'/>"/>

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. BRIC carries big science in small canisters
2. Too many chefs: Smaller groups exhibit more accurate decision-making
3. Devil in disguise: A small coral-eating worm may mean big trouble for reefs
4. Chemists work with small peptide chains may revolutionize study of enzymes and diseases
5. Small peptides as potential antibiotics
6. Small step towards growing tissue in the lab
7. Newly identified small-RNA pathway defends genome against the enemy within
8. Small biomass power plants could help rural economies, stabilize national power grid, MU study finds
9. Fertilizer in small doses yields higher returns for less money
10. Researchers develop antibody-targeted treatment for recurrent small-cell lung cancer
11. Imaging dynamics of small biomolecules inside live cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Mediterranean each year, but its deep-blue waters host ... 1,000 alien species, including fish, crustaceans, and algae ... activities. In the open-access journal Frontiers in ... analyzed data from a new information system developed ... introduction of alien species has changed the native ...
(Date:9/30/2014)... watermelon, salmon, and strawberries all have in common? ... of chromosomes and are diploid, these organisms are all ... chromosomesseedless watermelon and salmon have 3 and 4 sets ... this might seem surprising, in fact most plant species ... over a century ago, but only recently, with the ...
(Date:9/30/2014)... Prenatal exposure to tetrachloroethylene (PCE) in drinking water ... abruption, according to a new study led by ... , The study, published in the journal ... 1,019 unexposed pregnancies among 1,766 women in Cape ... late 1960s to the early 1980s by the ...
Breaking Biology News(10 mins):Biodiversity in the Mediterranean is threatened by alien species 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4Contaminated water linked to pregnancy complications, BU study finds 2
... an odd-looking mouse discovered through a U.S. government breeding program in ... set of ribs in its neck and nobody knew why. ... of California, San Francisco has now spilled the genetic secrets of ... new wrinkle in the genetic code an entirely unrecognized way ...
... to announce BIOLOGY OPEN (BiO), a new online only, ... of the biological sciences including cell science, developmental biology ... rapid publication for peer reviewed, scientifically sound observations and ... will address some big issues in publishing and is ...
... Two groups of small fish, one from a Caribbean island and ... fastest rates of evolution known in any organism, according to a ... found from Massachusetts to Venezuela -- and they are all pretty ... Davis graduate student working with Peter Wainwright, a professor of evolution ...
Cached Biology News:Mutant mouse reveals new wrinkle in genetic code, say UCSF scientists 2Mutant mouse reveals new wrinkle in genetic code, say UCSF scientists 3Announcing BIOLOGY OPEN from the Company of Biologists 2'Explosive' evolution in pupfish 2
(Date:10/1/2014)... METTLER TOLEDO’s newly improved XS balance ... balances as well as a dual range microbalance ... new SmartPan™ weighing pan delivers results up to twice ... balances, ergonomic design details mean users no longer need ... long periods in front of the balance. Barbara Bienlein, ...
(Date:10/1/2014)... CHICAGO , Oct. 1, 2014 ... purity Mannose (USP/NF, EP), manufactured in the ... conditions.  "Mannose has long been recognized for playing ... is a growing body of evidence that media ... and consistency of protein glycosylation," according to Dr. ...
(Date:10/1/2014)... September 30, 2014 New applications of ... that have evolved in nature over millennia are featured ... materials for applications in biophotonics in the October ... The journal is published by SPIE, the international society ... Several of the peer-reviewed articles are accessible via open ...
(Date:10/1/2014)... Sept. 30, 2014 This report ... in US$ Million by the following Product ... Enzymes. Specific end-use segments also analyzed are ... The report provides separate comprehensive analytics ... Middle East, and Latin America. Annual estimates ...
Breaking Biology Technology:METTLER TOLEDO’s XS Balance Line Delivers Performance and Ergonomics To Safeguard Health in the Workplace 2METTLER TOLEDO’s XS Balance Line Delivers Performance and Ergonomics To Safeguard Health in the Workplace 3Pfanstiehl Launches cGMP-produced Mannose for Cell Culture Media Optimization & Glycoprotein Biosynthesis 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 3Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26
... Virent , a University of Wisconsin-Madison spinoff working ... from the Department of Energy for continued research. , ,The ... and sugar in a one-step process as part of a ... of the problems of storing hydrogen, a highly explosive gas. ...
... for the 21st Century Act, commonly called Check 21, ... electronic check imaging. , ,Check 21, which will come ... the efficiency of the payments system by legalizing the ... the physical documents. Using the substitute check, banks are ...
... live in interesting times. Not so long ago, we IT practitioners may ... moons on them. What we did was a mystery to the rest ... magic trick gone bad, there was a huge puff of smoke on ... for all the world to see. , ,Somewhere in all of that, ...
Cached Biology Technology:Wisconsin firms make acquisitions for Check 21 readiness 2IT leadership is not just for CIOs anymore 2
... workstation offers precise 96 and 384-well transfers ... 100ul and 200ul disposable tips, the 96 ... and precision across a volume range from ... two positions that enable indexing into 384 ...
... Rabbit Tissue Arrays contain 60 rabbit tissue samples ... contains 4 unstained slides and 1 hematoxylin and ... slide contains 15 different tissues from 4 rabbit ... per slide. Each tissue sample (or core) is ...
A univariate (peak height or area) quantitative multi-component analysis package....
... The new, upgraded micro 10 represents ... that brings many of the benefits of ... of the small benchtop dispenser. Dispensing accurate ... well, the micro 10 has unique advantages ...
Biology Products: