Navigation Links
Small variations in genetic code can team up to have a bi
Date:5/2/2014

Scientists at USC have definitively demonstrated that large sets of variations in the genetic code that do not individually appear to have much effect can collectively produce significant changes in an organism's physical characteristics.

Studying the budding yeast Saccharomyces cerevisiae, USC's Matthew B. Taylor and Ian M. Ehrenreich found that the effects of these genetic variants can depend on four or more other variants in an individual's genome.

Most genetic analyses of heritable physical characteristics, including genome-wide association studies in human populations, focus on so-called "additive" variants that have effects that occur regardless of the organism's genetic background. Taylor and Ehrenreich, however, found that higher-order interactions of five or more places along the genome can have major impacts, and may help explain the so-called "missing heritability" problem, in which additive genetic variants do not entirely explain many inherited diseases and traits.

"Studies focused only on additive effects often explain just a fraction of the genetic basis of many traits. The question is, what are we missing?" said Ehrenreich, assistant professor of molecular biology at the USC Dornsife College of Letters, Arts and Sciences, and corresponding author of a paper on the study that was published by PLOS Genetics on May 1.

An alternative view of Taylor and Ehrenreich's findings is that genetic variants that have the potential to cause major changes in an organism's phenotype can be completely canceled out if they occur in the "wrong" genomic background.

"It's exciting to provide a characterized example of how genetic background can influence the effects of mutations. We hope that this will open the door for future studies to tease apart how these complex interactions happen," said Taylor, a PhD student in the Molecular and Computational Biology Section at USC.

Their work could impact genetic mapping studies, suggesting that researchers will need to take an approach to understanding the genotype-phenotype relationship that encompasses complex non-additive effects.

Taylor and Ehrenreich plan to take a closer look at the molecular mechanisms that underlie these interactions, in the hopes of providing basic insights into how they occur in biological systems.


'/>"/>

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California
Source:Eurekalert

Related biology news :

1. BRIC carries big science in small canisters
2. Too many chefs: Smaller groups exhibit more accurate decision-making
3. Devil in disguise: A small coral-eating worm may mean big trouble for reefs
4. Chemists work with small peptide chains may revolutionize study of enzymes and diseases
5. Small peptides as potential antibiotics
6. Small step towards growing tissue in the lab
7. Newly identified small-RNA pathway defends genome against the enemy within
8. Small biomass power plants could help rural economies, stabilize national power grid, MU study finds
9. Fertilizer in small doses yields higher returns for less money
10. Researchers develop antibody-targeted treatment for recurrent small-cell lung cancer
11. Imaging dynamics of small biomolecules inside live cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2016)... PROVO and SANDY, Utah ... Ontario (NSO), which operates the highest sample volume laboratory ... and Tute Genomics and UNIConnect, leaders in clinical sequencing ... announced the launch of a project to establish the ... panel. NSO has been contracted by ...
(Date:3/15/2016)... 15, 2016 --> ... Transparency Market Research "Digital Door Lock Systems Market - Global ... 2023," the global digital door lock systems market in terms ... and is forecast to grow at a CAGR of 31.8% ... and medium enterprises (MSMEs) across the world and high industrial ...
(Date:3/11/2016)... 11, 2016 http://www.apimages.com ) - --> ... is available at AP Images ( http://www.apimages.com ) - ... used to produce the new refugee identity cards. DERMALOG will be ... CeBIT in Hanover next week.   --> ... be used to produce the new refugee identity cards. DERMALOG will ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... Baltimore, MD (PRWEB) , ... April 27, 2016 ... ... appointed Greg Lamka, PhD to its Scientific Advisory Board. Dr. Lamka will assist ... of plant pathogen detection. , PathSensors deploys the CANARY® test platform for ...
(Date:4/27/2016)... ... ... Global Stem Cells Group and the University of Santiago Biotechnology Lab have ... for potential stem cell protocol management for 2016 – 2020. , In 2015, ... establish a working agenda and foster initiatives to promote stem cell research and development ...
(Date:4/26/2016)... ANGELES, Calif. (PRWEB) , ... April 27, 2016 ... ... Angeles office of Lewis Roca Rothgerber Christie LLP as an associate in the ... prosecuting U.S. and international electrical, mechanical and electromechanical patent applications. He has an ...
(Date:4/26/2016)... ... April 26, 2016 , ... Heidelberg ... the latest technology innovation for its Volume Pattern Generator (VPG) line of lithography ... of advanced photomasks as well as a solution for mid volume direct write ...
Breaking Biology Technology: