Navigation Links
Small protein plays big role in asthma severity
Date:8/1/2013

Bethesda, MDA new culprit has been identified that likely plays a big role in the severity of asthmaa small protein chemokine called CCL26. These findings were published in the Journal of Leukocyte Biology and represent the first demonstration that CCL26 is a potent regulator of the migration of asthmatic eosinophils, commonly observed in asthmatic airways. Results from this discovery may lead to new drug targets for the treatment of asthma.

"We hope that these studies will help to develop a new treatment that would specifically abrogate bronchial inflammation and provide a specific, efficacious and well-tolerated alternative to the current therapy," said Michel Laviolette, M.D., a researcher involved in the work from the Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Qubec, Facult de Mdecine, Universit Laval, Qubec, Canada.

Specifically, data from the report suggest that the chemokine CCL26 plays a crucial role in asthma pathogenesis and its severity by supporting the recruitment of eosinophils early in the development of the disease, and possibly later in severe asthma associated with persisting lung eosinophilia. To make this discovery, scientists used blood from healthy and asthmatic subjects to isolate eosinophils and measure their migration response to CCL26 in vitro. Researchers also assessed their response to other chemokines, CCL11 and CCL24, and showed that only CCL26 induced an amplified eosinophil migration of asthmatic eosinophils compared to healthy cells. Interestingly, this additional migration occurred after a 6-hour incubation and, in contrast to the migration induced by the other chemokines, was not eradicated by blocking the chemokine receptor CCR3 shared by these three chemokines.

"The control of eosinophils is central to asthmatic diseases and the underlying mechanisms are prime targets for treatments for the de
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Small packages delivering huge results
2. Genetically modified cotton improves diet quality for small-scale farmers in India
3. Small but speedy: Short plants live in the evolutionary fast lane
4. A surprising new function for small RNAs in evolution
5. Goosefish capture small puffins over deep water of Northwest Atlantic
6. Notre Dame researcher is studying role small dams play in pollution control
7. How our cells cope with toxic small molecules
8. Developing microbial cell factories by employing synthetic small regulatory RNAs
9. EGFR mutation not prognostic factor in non-small cell lung cancer
10. Small Animal Regional Anesthesia and Analgesia
11. Small Animal Soft Tissue Surgery, (with DVD-ROM)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014  Automation is fundamentally transforming the travel ... at international borders. Over the past decade, ePassports, ... veteran travelers to self process through border control ... at an increasing number of airports, seaports, and ... According to Maxine Most , Principal at ...
(Date:12/11/2014)... --Research and Markets , ... ) has announced the addition of the ... their offering. One major trend ... multimodal biometric systems. Multimodal biometric systems utilize more ... and identification purposes. This helps to reduce the ...
(Date:12/10/2014)... , Dec. 8, 2014 You,ve been here before: ... but can,t remember your password, site key or the answer ... your first grade teacher? Today, Hoyos ... app that will finally put an end to the ... 1U TM . 1U leverages a user,s smartphone to ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... the future of their health? On May 27, researchers ... National Cancer Institute (NCI), along with Group Health Cooperative in ... that question during the one-day symposium "Multiplex Initiative: Implications for ... symposium. It will be held from 7:30 a.m. 3:30 ...
... Ariz. May 12, 2010 Dr. James Bogenberger ... the American Cancer Society to research acute myeloid leukemia ... myeloid leukemia (AML), the most common and deadliest acute ... the body,s white blood cells that battle infections. ...
... tool that relies on magnetic fields and radio ... soft tissuesmay soon become even more useful. ... has unveiled the first "phantom" for calibrating MRI ... prototype, named Phannie, was developed in collaboration with ...
Cached Biology News:Symposium: Implications for the future of personalize medicine 2Symposium: Implications for the future of personalize medicine 3TGen researcher awarded American Cancer Society fellowship 2Meet Phannie, NIST's standard 'phantom' for calibrating MRI machines 2
(Date:12/19/2014)... Dec. 19, 2014 Decision Resources Group finds ... at a 12 percent compound annual growth rate through ... aging population and the increasing adoption of dental implants. ... will also spur demand for dental biomaterials because ... and periodontal treatments. Other key findings from ...
(Date:12/19/2014)... December 18, 2014 Ed Bilsky, Ph.D., ... the Center for Excellence in the Neurosciences (CEN), and ... has been selected as a member of the prestigious ... first neuroscientist from Maine to receive this honor. , ... supported entirely by the Dana Foundation. Its mission ...
(Date:12/19/2014)... With only 2 weeks left of ... Sartorius Biohit products . The product specials include Buy ... Pipette Trade-in Program, and free pipette tips. , Sartorius ... the world. They are ideal for lab technicians performing ... ,     Full volume range of 0.1 uL to ...
(Date:12/17/2014)... 2014 The Activated Carbon Manufacturing ... is why IBISWorld updated its original industry research report. ... from an intensified focus on environmental policy. Over the ... standards for power plants and a range of other ... Industry Analyst Sarah Kahn, “a range of downstream industrial ...
Breaking Biology Technology:Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 3Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3
... May 11 /PRNewswire-Asia-FirstCall/ -- China,Baicaotang Medicine Ltd. (OTC Bulletin Board: ... in the, Guangxi Province of China announced today that ... the,Company. , , , ... Mr. Tang Hui Tian , Chairman and CEO of CBT, ...
... of more affordable drugs, vaccines and diagnostics that would ... from a growing number of collaborations between biotech firms ... published Mon. May 10 in the UK journal ... countries, together with colleagues at Canada,s McLaughlin-Rotman Centre for ...
... May 10 /PRNewswire-Asia-FirstCall/ -- China Sky One Medical,Inc. ("China Sky ... pharmaceutical company producing over-the-counter drugs in, the People,s Republic of China , ... of $10.1 million for the first quarter,ended March 31, ... ...
Cached Biology Technology:Harbinger Research Initiates Coverage on China Baicaotang Medicine, Ltd. 2Harbinger Research Initiates Coverage on China Baicaotang Medicine, Ltd. 3Cheaper drugs, vaccines forecast as collaborations grow between developing countries' biotech firms 2Cheaper drugs, vaccines forecast as collaborations grow between developing countries' biotech firms 3Cheaper drugs, vaccines forecast as collaborations grow between developing countries' biotech firms 4Cheaper drugs, vaccines forecast as collaborations grow between developing countries' biotech firms 5Cheaper drugs, vaccines forecast as collaborations grow between developing countries' biotech firms 6Cheaper drugs, vaccines forecast as collaborations grow between developing countries' biotech firms 7China Sky One Medical Announces Preliminary First Quarter 2010 Results; Reschedules Earnings Conference Call 2China Sky One Medical Announces Preliminary First Quarter 2010 Results; Reschedules Earnings Conference Call 3China Sky One Medical Announces Preliminary First Quarter 2010 Results; Reschedules Earnings Conference Call 4China Sky One Medical Announces Preliminary First Quarter 2010 Results; Reschedules Earnings Conference Call 5China Sky One Medical Announces Preliminary First Quarter 2010 Results; Reschedules Earnings Conference Call 6
This free-standing laminar flow hood provides a vertical flow of HEPA-filtered air to create a clean processing area. It includes a fluorescent light and motorized sliding shield. Options include wor...
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. ID clarifier: rack ...
... GX-1000 3-D Shaker , ,Product Information ... of the GyroTwister GX-1000 is extremely efficient, ... general mixing as well as staining gels, ... continuously adjustable across a broad range. A ...
...
Biology Products: