Navigation Links
Small protein plays big role in asthma severity
Date:8/1/2013

Bethesda, MDA new culprit has been identified that likely plays a big role in the severity of asthmaa small protein chemokine called CCL26. These findings were published in the Journal of Leukocyte Biology and represent the first demonstration that CCL26 is a potent regulator of the migration of asthmatic eosinophils, commonly observed in asthmatic airways. Results from this discovery may lead to new drug targets for the treatment of asthma.

"We hope that these studies will help to develop a new treatment that would specifically abrogate bronchial inflammation and provide a specific, efficacious and well-tolerated alternative to the current therapy," said Michel Laviolette, M.D., a researcher involved in the work from the Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Qubec, Facult de Mdecine, Universit Laval, Qubec, Canada.

Specifically, data from the report suggest that the chemokine CCL26 plays a crucial role in asthma pathogenesis and its severity by supporting the recruitment of eosinophils early in the development of the disease, and possibly later in severe asthma associated with persisting lung eosinophilia. To make this discovery, scientists used blood from healthy and asthmatic subjects to isolate eosinophils and measure their migration response to CCL26 in vitro. Researchers also assessed their response to other chemokines, CCL11 and CCL24, and showed that only CCL26 induced an amplified eosinophil migration of asthmatic eosinophils compared to healthy cells. Interestingly, this additional migration occurred after a 6-hour incubation and, in contrast to the migration induced by the other chemokines, was not eradicated by blocking the chemokine receptor CCR3 shared by these three chemokines.

"The control of eosinophils is central to asthmatic diseases and the underlying mechanisms are prime targets for treatments for the debilitating and sometimes life-threatening symptoms of asthma and allergy," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "This report shows that CCL26 could be a novel drug target to regulate eosinophils in these diseases."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Small packages delivering huge results
2. Genetically modified cotton improves diet quality for small-scale farmers in India
3. Small but speedy: Short plants live in the evolutionary fast lane
4. A surprising new function for small RNAs in evolution
5. Goosefish capture small puffins over deep water of Northwest Atlantic
6. Notre Dame researcher is studying role small dams play in pollution control
7. How our cells cope with toxic small molecules
8. Developing microbial cell factories by employing synthetic small regulatory RNAs
9. EGFR mutation not prognostic factor in non-small cell lung cancer
10. Small Animal Regional Anesthesia and Analgesia
11. Small Animal Soft Tissue Surgery, (with DVD-ROM)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... LLC , a medical device company focused on improving the safety ... ISO 13485 Certification, the global standard for medical device quality management ... ... for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, as it validates our ...
(Date:6/30/2017)... , June 30, 2017 Today, ... developer and supplier of face and eye tracking ... Featured Product provider program. "Artificial ... innovative way to monitor a driver,s attentiveness levels ... from being able to detect fatigue and prevent ...
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at ... between startups and global businesses, taking place in ... startups will showcase the solutions they have built with IBM ... France is one of the most ... increase in the number of startups created between 2012 and ...
Breaking Biology News(10 mins):
(Date:9/22/2017)... ... September 22, 2017 , ... HOLLOWAY AMERICA, a ... at premier packaging event PACK EXPO International in Las Vegas from September 25 ... (PMMI). , At this year’s PACK EXPO at the Last Vegas Convention Center, ...
(Date:9/21/2017)... ... September 21, 2017 , ... Vixiar Medical ... engineering and manufacturing functions to The LaunchPort™ Accelerator at the City Garage in ... range of manufacturing and business services to its Residents. , Vixiar Medical ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... enable the world’s most progressive pharma and biotech organizations to do more clinical ... pharma and biotech events in Q4. , DrugDev will demonstrate DrugDev Spark™, the ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... the election of Paul Hermes, Entrepreneur in Residence at Medtronic, Inc., to serve ... developed a proprietary, tissue-engineered scaffold for anterior cruciate ligament (ACL) reconstruction that is ...
Breaking Biology Technology: