Navigation Links
Small peptides as potential antibiotics
Date:3/25/2014

Drug approval requires a deep understanding of the mechanism of action

The team of Julia Bandow, who heads the RUB's Junior Research Group Microbial Antibiotic Research, has been studying the MP196 peptide as a representative of a group of very small positively charged peptides that consist of some four to ten amino acids. Earlier studies had shown that MP196 is efficient against various bacteria, including particularly problematic multi-resistant pathogens that frequently cause sepsis. How MP196 kills bacteria remained unclear. However, in order for a new substance to be approved as a drug, its mechanism of action has to be fully understood.

Peptide disrupts cell wall biosynthesis and cell respiration

The biologists have closed this gap. They showed that the MP196 peptide integrates into the bacterial cell membrane. In doing so, it delocalises proteins localised at the bacterial cell membrane that participate in vital processes. Two processes in particular are severely affected: MP196 disrupts the biosynthesis of the cell wall, i.e. of the outer envelope that encloses the cell membrane and provides physical stability. It also inhibits cell respiration and, consequently, the production of the energy-storing molecule ATP. This results in cellular energy deficiency, thus preventing the synthesis of macromolecules vital for bacterial growth.

Developing resistances against MP196 may be particularly difficult

"By delocalising crucial membrane proteins, MP196 disrupts a number of cellular processes that take place at the membrane," says Julia Bandow. "As a result, the development of resistance against the peptide seems particularly difficult." The researchers are confident that MP196 can serve as a scaffold to develop drugs that attack certain classes of bacteria without damaging human cells. The interaction of MP196 with the cell membrane was dependent on the fatty acids present in the membrane. The membrane composition varies not only between human and bacterial cells, but also between different classes of bacteria.


'/>"/>

Contact: Dr. Julia Bandow
julia.bandow@rub.de
49-234-322-3102
Ruhr-University Bochum
Source:Eurekalert

Related biology news :

1. Small step towards growing tissue in the lab
2. Newly identified small-RNA pathway defends genome against the enemy within
3. Small biomass power plants could help rural economies, stabilize national power grid, MU study finds
4. Fertilizer in small doses yields higher returns for less money
5. Researchers develop antibody-targeted treatment for recurrent small-cell lung cancer
6. Imaging dynamics of small biomolecules inside live cells
7. NIST microanalysis technique makes the most of small nanoparticle samples
8. Smaller meals more times per day may curb obesity in cats
9. Special air filter blocks small particles called UFPs from getting inside cars
10. A battery small enough to be injected, energetic enough to track salmon
11. Small non-coding RNAs could be warning signs of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by Solution ... Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to 2022", ... 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at a ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... Research and Markets has announced the addition ... their offering. ... tracking market to grow at a CAGR of 30.37% during the ... 2017-2021, has been prepared based on an in-depth market analysis with ... its growth prospects over the coming years. The report also includes ...
(Date:4/11/2017)... 11, 2017 NXT-ID, Inc. (NASDAQ:   ... announces the appointment of independent Directors Mr. Robin D. ... Board of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , ... forward to their guidance and benefiting from their considerable expertise ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... DuPont Pioneer and recently ... have entered into a multiyear collaboration to identify and characterize novel CRISPR-Cas nucleases. ... for gene editing across all applications. , Under the terms of the agreement, ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Rosalind™, the first-ever genomics analysis platform specifically designed for life science researchers ... honor of pioneering researcher Rosalind Franklin, who made a major contribution to ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ComplianceOnline’s Medical Device ... on 7th and 8th June 2018 in San Francisco, CA. The Summit brings together ... as several distinguished CEOs, board directors and government officials from around the world to ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the ... million people each year. Especially those living in larger cities are affected by air ... one of the most pollution-affected countries globally - decided to take action. , “I ...
Breaking Biology Technology: