Navigation Links
Small peptides as potential antibiotics
Date:3/25/2014

Drug approval requires a deep understanding of the mechanism of action

The team of Julia Bandow, who heads the RUB's Junior Research Group Microbial Antibiotic Research, has been studying the MP196 peptide as a representative of a group of very small positively charged peptides that consist of some four to ten amino acids. Earlier studies had shown that MP196 is efficient against various bacteria, including particularly problematic multi-resistant pathogens that frequently cause sepsis. How MP196 kills bacteria remained unclear. However, in order for a new substance to be approved as a drug, its mechanism of action has to be fully understood.

Peptide disrupts cell wall biosynthesis and cell respiration

The biologists have closed this gap. They showed that the MP196 peptide integrates into the bacterial cell membrane. In doing so, it delocalises proteins localised at the bacterial cell membrane that participate in vital processes. Two processes in particular are severely affected: MP196 disrupts the biosynthesis of the cell wall, i.e. of the outer envelope that encloses the cell membrane and provides physical stability. It also inhibits cell respiration and, consequently, the production of the energy-storing molecule ATP. This results in cellular energy deficiency, thus preventing the synthesis of macromolecules vital for bacterial growth.

Developing resistances against MP196 may be particularly difficult

"By delocalising crucial membrane proteins, MP196 disrupts a number of cellular processes that take place at the membrane," says Julia Bandow. "As a result, the development of resistance against the peptide seems particularly difficult." The researchers are confident that MP196 can serve as a scaffold to develop drugs that attack certain classes of bacteria without damaging human cells. The interaction of MP196 with the cell membrane was dependent on the fatty acids present in the membrane. The membrane composition varies not only between human and bacterial cells, but also between different classes of bacteria.


'/>"/>

Contact: Dr. Julia Bandow
julia.bandow@rub.de
49-234-322-3102
Ruhr-University Bochum
Source:Eurekalert

Related biology news :

1. Small step towards growing tissue in the lab
2. Newly identified small-RNA pathway defends genome against the enemy within
3. Small biomass power plants could help rural economies, stabilize national power grid, MU study finds
4. Fertilizer in small doses yields higher returns for less money
5. Researchers develop antibody-targeted treatment for recurrent small-cell lung cancer
6. Imaging dynamics of small biomolecules inside live cells
7. NIST microanalysis technique makes the most of small nanoparticle samples
8. Smaller meals more times per day may curb obesity in cats
9. Special air filter blocks small particles called UFPs from getting inside cars
10. A battery small enough to be injected, energetic enough to track salmon
11. Small non-coding RNAs could be warning signs of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... With the biometrics market to exceed ... technologies that innovative and agile startups must incorporate ... the changing competitive landscape: multifactor authentication (MFA), point-of-sale ... "Companies can no longer afford to cut ... Dimitrios Pavlakis , Industry Analyst at ABI Research. ...
(Date:2/21/2017)... PORTLAND, Ore. , Feb. 22, 2017  IBM ... Companies (Avamere Health Services, Infinity Rehab, Signature Hospice, Home ... that will apply the power of IBM cognitive computing ... health centers. By analyzing data streaming from sensors in ... physical and environmental conditions, and obtain deeper learnings into ...
(Date:2/21/2017)... , February 21, 2017 Der ... US-Dollar wachsen. Nach einem Gespräch mit mehr als 50 Vertretern ... Hindernisse zu überwinden gilt, um diese Prognose zu realisieren. ... ... die Mobilisierung der finanziellen Mittel für die Biobank, die ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... NEW YORK , Feb. 23, ... , a leading digital health company, and ... of telemedicine and remote patient monitoring, announce they ... reimbursements.  DN Telehealth maximizes collaboration ... real-time, extending consultations beyond a physical clinical setting ...
(Date:2/23/2017)... Financial Highlights (in ... Months Ended December 31,Twelve Months Ended December 31,20162015% ... $           300$     ... Revenue 3539(10)%9498(4)%Kuvan Net Product Revenue ... 756025%297303(2)%Vimizim Net Product Revenue ...
(Date:2/23/2017)... , ... February 23, 2017 , ... ... Discovery Services portfolio to include an array of biochemical analyses critical for ... data to drive their hit-to-lead and SAR programs, including inhibitor potency and selectivity, ...
(Date:2/23/2017)... 2017 /PRNewswire/ - The Fight Against Cancer Innovation Trust ... are pleased to report that Fusion Pharmaceuticals Inc. (Fusion) ... & Johnson Innovation – JJDC, Inc. (JJDC) as the ... TPG Biotechnology Partners, and Genesys Capital, as well as ... ...
Breaking Biology Technology: