Navigation Links
Small peptides as potential antibiotics
Date:3/25/2014

Drug approval requires a deep understanding of the mechanism of action

The team of Julia Bandow, who heads the RUB's Junior Research Group Microbial Antibiotic Research, has been studying the MP196 peptide as a representative of a group of very small positively charged peptides that consist of some four to ten amino acids. Earlier studies had shown that MP196 is efficient against various bacteria, including particularly problematic multi-resistant pathogens that frequently cause sepsis. How MP196 kills bacteria remained unclear. However, in order for a new substance to be approved as a drug, its mechanism of action has to be fully understood.

Peptide disrupts cell wall biosynthesis and cell respiration

The biologists have closed this gap. They showed that the MP196 peptide integrates into the bacterial cell membrane. In doing so, it delocalises proteins localised at the bacterial cell membrane that participate in vital processes. Two processes in particular are severely affected: MP196 disrupts the biosynthesis of the cell wall, i.e. of the outer envelope that encloses the cell membrane and provides physical stability. It also inhibits cell respiration and, consequently, the production of the energy-storing molecule ATP. This results in cellular energy deficiency, thus preventing the synthesis of macromolecules vital for bacterial growth.

Developing resistances against MP196 may be particularly difficult

"By delocalising crucial membrane proteins, MP196 disrupts a number of cellular processes that take place at the membrane," says Julia Bandow. "As a result, the development of resistance against the peptide seems particularly difficult." The researchers are confident that MP196 can serve as a scaffold to develop drugs that attack certain classes of bacteria without damaging human cells. The interaction of MP196 with the cell membrane was dependent on the fatty acids present in the membrane. The membrane composition varies not only between human and bacterial cells, but also between different classes of bacteria.


'/>"/>

Contact: Dr. Julia Bandow
julia.bandow@rub.de
49-234-322-3102
Ruhr-University Bochum
Source:Eurekalert

Related biology news :

1. Small step towards growing tissue in the lab
2. Newly identified small-RNA pathway defends genome against the enemy within
3. Small biomass power plants could help rural economies, stabilize national power grid, MU study finds
4. Fertilizer in small doses yields higher returns for less money
5. Researchers develop antibody-targeted treatment for recurrent small-cell lung cancer
6. Imaging dynamics of small biomolecules inside live cells
7. NIST microanalysis technique makes the most of small nanoparticle samples
8. Smaller meals more times per day may curb obesity in cats
9. Special air filter blocks small particles called UFPs from getting inside cars
10. A battery small enough to be injected, energetic enough to track salmon
11. Small non-coding RNAs could be warning signs of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... 2017 No two people are believed ... New York University Tandon School of Engineering and ... that partial similarities between prints are common enough ... phones and other electronic devices can be more ... lies in the fact that fingerprint-based authentication systems ...
(Date:4/5/2017)... 2017 KEY FINDINGS The global ... a CAGR of 25.76% during the forecast period of ... factor for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is ... geography. The stem cell market of the product is ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... July 18, 2017 , ... ... United States Patent and Trademark Office for its Patent Applications 14/858,857 and 13/669,785 ... allowances of these patent applications further expand the protection of G-CON’s R&D investments ...
(Date:7/17/2017)... ... July 17, 2017 , ... Whitehouse Laboratories is ... to encompass the full series of ISO 80369 standard test procedures. The ISO ... device and drug delivery systems. With this recent expansion, Whitehouse Labs becomes one ...
(Date:7/17/2017)... ... July 17, 2017 , ... Neurodevelopmental disorders ... range of overlapping clinical features. The advancement of targeted next-generation sequencing (NGS) has ... research and testing. , However, designing a custom panel for disease research ...
(Date:7/16/2017)... ... July 16, 2017 , ... ... analytical instruments announced the launch of its new line of Rocking and Waving ... and waving shaker models (both analog and digital) for laboratory applications in a ...
Breaking Biology Technology: