Navigation Links
Small peptides as potential antibiotics
Date:3/25/2014

Drug approval requires a deep understanding of the mechanism of action

The team of Julia Bandow, who heads the RUB's Junior Research Group Microbial Antibiotic Research, has been studying the MP196 peptide as a representative of a group of very small positively charged peptides that consist of some four to ten amino acids. Earlier studies had shown that MP196 is efficient against various bacteria, including particularly problematic multi-resistant pathogens that frequently cause sepsis. How MP196 kills bacteria remained unclear. However, in order for a new substance to be approved as a drug, its mechanism of action has to be fully understood.

Peptide disrupts cell wall biosynthesis and cell respiration

The biologists have closed this gap. They showed that the MP196 peptide integrates into the bacterial cell membrane. In doing so, it delocalises proteins localised at the bacterial cell membrane that participate in vital processes. Two processes in particular are severely affected: MP196 disrupts the biosynthesis of the cell wall, i.e. of the outer envelope that encloses the cell membrane and provides physical stability. It also inhibits cell respiration and, consequently, the production of the energy-storing molecule ATP. This results in cellular energy deficiency, thus preventing the synthesis of macromolecules vital for bacterial growth.

Developing resistances against MP196 may be particularly difficult

"By delocalising crucial membrane proteins, MP196 disrupts a number of cellular processes that take place at the membrane," says Julia Bandow. "As a result, the development of resistance against the peptide seems particularly difficult." The researchers are confident that MP196 can serve as a scaffold to develop drugs that attack certain classes of bacteria without damaging human cells. The interaction of MP196 with the cell membrane was dependent on the fatty acids present in the membrane. The membrane composition varies not only between human and bacterial cells, but also between different classes of bacteria.


'/>"/>

Contact: Dr. Julia Bandow
julia.bandow@rub.de
49-234-322-3102
Ruhr-University Bochum
Source:Eurekalert

Related biology news :

1. Small step towards growing tissue in the lab
2. Newly identified small-RNA pathway defends genome against the enemy within
3. Small biomass power plants could help rural economies, stabilize national power grid, MU study finds
4. Fertilizer in small doses yields higher returns for less money
5. Researchers develop antibody-targeted treatment for recurrent small-cell lung cancer
6. Imaging dynamics of small biomolecules inside live cells
7. NIST microanalysis technique makes the most of small nanoparticle samples
8. Smaller meals more times per day may curb obesity in cats
9. Special air filter blocks small particles called UFPs from getting inside cars
10. A battery small enough to be injected, energetic enough to track salmon
11. Small non-coding RNAs could be warning signs of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2016)... RALEIGH, N.C. and GENEVA, Dec, 20, 2016 ... performance biometric data sensor technology, and STMicroelectronics ... across the spectrum of electronics applications, announced today ... scalable development kit for biometric wearables that includes ... integrated with Valencell,s Benchmark™ biometric sensor ...
(Date:12/16/2016)... -- The global wearable medical device market, in terms of value, ... 5.31 billion in 2016, at a CAGR of 18.0% during the ... ... medical devices, launch of a growing number of smartphone-based healthcare apps ... providers, and increasing focus on physical fitness. Furthermore, ...
(Date:12/15/2016)... 15, 2016 Advancements in biometrics ... wellness and wellbeing (HWW), and security of ... new passenger vehicles begin to feature fingerprint ... heart beat monitoring, brain wave monitoring, stress ... and pulse detection. These will be driven ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... 18, 2017  HUYA Bioscience International, (HUYA), the leader ... pharmaceutical innovations, announced today a strategic collaboration ... Investment Company (referred to as CAS Innovation). The collaboration ... by leading scientists at CAS to meet the medical ... is the first company to have recognized ...
(Date:1/18/2017)... 2017 /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: SQD; ... that develops and commercializes proprietary technologies and products ... today announced that Cameron Prange , President ... from its Board of Directors.  Mr. Prange,s resignation ... that have limited both his ability to act ...
(Date:1/17/2017)... ... January 17, 2017 , ... LGC Maine Standards ... VALIDATE® SP2 calibration verification / linearity test kit. VALIDATE® SP2 evaluates Albumin, C-reactive ... SP2 kit is prepared using the CLSI recommended “equal delta” method for linearity ...
(Date:1/17/2017)... , Jan. 17, 2017 The ... at a CAGR of around 7.5% over the ... 2025. Some of the prominent trends that the ... incidences of diseases & graft transplant surgeries and ... Material the market is categorized into immunomodulatory biomaterials, ...
Breaking Biology Technology: