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Small mutation changes brain freeze to hot foot
Date:5/8/2014

very surprising and it demonstrates that making a single-point mutation produced a profound change in the temperature sensitivity of the protein, but it did not affect the chemical sensitivity," Grandl said. "It shows these mechanisms are to some degree distinct."

Grandl said that taken together, the findings also suggest that the effectiveness of such a small mutation might have been key to a single ancestral ion channel evolving into the wide diversity of temperature-activated ion channels we see today.


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Contact: Karl Bates
karl.bates@duke.edu
919-681-8054
Duke University
Source:Eurekalert  

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