Navigation Links
Small molecules shed light on cancer therapies

Patients suffering from an aggressive brain cancer will benefit from the results of a University of Illinois study that could advance the development of targeted gene therapies and improve prognosis.

"We have advanced the understanding of the role of microRNAs on glioblastoma multiforme, a deadly brain cancer, by studying the networks between the microRNAs and their target genes associated with different stages of cancer development and progression," said Kristin Delfino, a U of I doctoral candidate in animal science with a focus in genetics and bioinformatics.

What exactly are microRNAs? microRNAs are small, non-coding RNA molecules that regulate the expression of genes such as oncogenes or tumor suppressor genes. U of I researchers used a novel approach to identify the simultaneous association between tens of thousands of microRNAs, target genes, and glioblastoma progression and survival.

Delfino integrated clinical information such as race, gender, therapy, survival, and cancer stage from 253 patients together with genome-wide microRNA and gene expression data.

"We looked at the big picture and how microRNAs work together," Delfino said. "When you look at a single microRNA alone, it can seem significant. But when you evaluate it in the context of all other microRNAs, some turn out to be more significant and others may not be as significant as they appear on their own. The systems biology approach that we implemented is critical for understanding the gene pathways influencing cancer."

The study evaluated 534 microRNAs together, unlike the typical method of studying one at a time. They confirmed 25 microRNAs previously associated with glioblastoma survival and identified 20 other microRNAs associated with initiation or growth of other cancer types such as breast cancer, ovarian cancer and gastric adenocarcinoma.

"These findings suggest common pathways that can be targeted with similar drugs already developed and tested for other cancers," said Sandra Rodriguez Zas, co-researcher and U of I professor of animal science and bioinformatics.

In addition, researchers found that some of the microRNA biomarkers of survival are personalized, Rodriguez Zas said. This means that they are particularly useful for patients of a specific race, gender or therapy. Other microRNAs are equally effective regardless of the clinical conditions of the patient.

"These biomarkers can serve as the basis to dig deeper into cancer studies," Delfino said. "Cancer affects us all in one way or another. Unfortunately, we still don't know how it's caused, what takes place when it is caused and how to cure it. But these biomarkers give us guidance into developing specific gene therapies to target glioblastoma."

Today patients can easily and cheaply be screened for microRNA and target gene levels, Rodriguez Zas said.

"Based on our research, that information can be used to select the most effective therapy and develop prognosis strategies," Rodriguez-Zas said.


Contact: Jennifer Shike
University of Illinois College of Agricultural, Consumer and Environmental Sciences

Related biology news :

1. Disordered networks synchronise faster than small world networks
2. Sneaky squid: Why small males have big sperm
3. TREW Marketing Introduces Smart Marketing for Engineers, a Free Guidebook for Small Businesses Targeting Technical Audiences
4. Study shows small-scale fisheries impact on marine life
5. Being small has its advantages, if you are a leaf
6. Researchers engineer functioning small intestine in laboratory experiments
7. Treatment approach to human Usher syndrome: Small molecules ignore stop signals
8. Transport Phenomena and Membrane Digestion in Small Intestinal Mucosa by Pensoft
9. Oceans harmful low-oxygen zones growing, are sensitive to small changes in climate
10. Wired for sound: A small fishs brain illustrates how people and other vertebrates produce sounds
11. Small change makes a big difference for ion channels
Post Your Comments:
(Date:11/17/2015)... , Nov. 17, 2015  Vigilant Solutions announces ... joined its Board of Directors. --> ... after recently retiring from the partnership at TPG Capital, ... companies with over $140 Billion in revenue.  He founded ... across all the TPG companies, from 1997 to 2013.  ...
(Date:11/12/2015)... Nov. 12, 2015  A golden retriever that stayed ... dystrophy (DMD) has provided a new lead for treating ... the Broad Institute of MIT and Harvard and the ... . Cell, pinpoints a protective ... the disease,s effects. The Boston Children,s lab of ...
(Date:11/11/2015)... --  MedNet Solutions , an innovative SaaS-based eClinical technology company ... to announce that it will be a Sponsor of the ... be held November 17-19 in Hamburg , ... iMedNet , MedNet,s easy-to-use, proven and affordable ... been able to deliver time and cost savings of up ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... ... , ... Matthew “Tex” VerMilyea, PhD, HCLD, has joined Texas Fertility Center as ... lab procedures as well as continue his research efforts into the emerging technologies of ... New Zealand to bring home a High Complexity Clinical Laboratory Director named Tex,” says ...
(Date:11/30/2015)... ... 30, 2015 , ... Global Stem Cells Group ... the Santiago Marriott. The Global Stem Cells Group GMP facility is equipped with ... qualified medical researchers and practitioners, experienced in administering stem cell protocols using highly ...
(Date:11/30/2015)... 2015 Partnership includes an MPP ... for the u niversity , s ... treatment s cale - up through ... Africa , where licensees based anywhere in the world will have ... --> Africa , where licensees based anywhere in the world ...
(Date:11/30/2015)... Spherix Incorporated (Nasdaq: SPEX ) an ... and monetization of intellectual property, today provided an ... to create shareholder value. Anthony ... on published reports, the total addressable market of ... Spherix will seek to secure fair and reasonable ...
Breaking Biology Technology: