Navigation Links
Small molecules mimic natural gene regulators
Date:6/3/2009

ANN ARBOR, Mich.---In the quest for new approaches to treating and preventing disease, one appealing route involves turning genes on or off at will, directly intervening in ailments such as cancer and diabetes, which result when genes fail to turn on and off as they should.

Scientists at the University of Michigan and the University of California at Berkeley have taken a step forward on that route by developing small molecules that mimic the behavior and function of a much larger and more complicated natural regulator of gene expression. The research, by associate professor of chemistry Anna Mapp and coworkers, is described in the current issue of the journal ACS Chemical Biology.

Molecules that can prompt genes to be active are called transcriptional activators because they influence transcription---the first step in the process through which instructions coded in genes are used to produce proteins. Transcriptional activators occur naturally in cells, but Mapp and other researchers have been working to develop artificial transcription factors (ATFs)---non-natural molecules programmed to perform the same function as their natural counterparts. These molecules can help scientists probe the transcription process and perhaps eventually be used to correct diseases that result from errors in gene regulation.

In previous work, Mapp and coworkers showed that an ATF they developed was able to turn on genes in living cells, but they weren't sure it was using the same mechanism that natural activators use. Both natural transcriptional activators and their artificial counterparts typically have two essential parts: a DNA-binding domain that homes in on the specific gene to be regulated, and an activation domain that attaches itself to the cell's machinery through a key protein-to-protein interaction and spurs the gene into action. The researchers wanted to know whether their ATFs attached to the same sites in the transcriptional machine
'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2

Related biology news :

1. Social parasites of the smaller kind
2. Small animal imaging facility is big boon to research
3. Handbook of small grain insects available now
4. New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed
5. 2007 ozone hole smaller than usual
6. Cilia: small organelles, big decisions
7. Research shows loggerhead sea turtles threatened by small-scale fishing operations
8. Small-scale fishing in Mexico rivals industrial fisheries in accidental turtle deaths
9. Sweet potato shines as new promise for small enterprise and hunger relief in developing countries
10. Identification of a novel class of (not-so) small RNAs
11. Small RNA plays parallel roles in bacterial metabolism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... Den 10. internationale konference om Genomik (ICG-10, ... - 25. oktober i Shenzhen , ... i år. Siden starten i 2006 er ICB blevet ... og er en af de mest dynamiske, entusiastiske og ... nylige gennembrud og fremskridt inden for ,omik,-forskning, som yderligere ...
(Date:7/31/2015)... La 10 th International Conference on Genomics ... 22 al 25 de octubre de 2015 en ... conferencia celebra su décimo aniversario. Desde su inauguración en el ... reuniones anuales más influyentes del mundo en el campo ,ómico, ... y mejores a nivel científico. ICG-10 se ...
(Date:7/30/2015)... , July 30, 2015 Cellecta, ... for gene function analysis and biomarker discovery, announced ... (sgRNA) Knockout Library targeting all human protein coding ... permanently "knock out" a gene,s function. Cellecta,s new ... high throughput screening tool so that researchers can ...
Breaking Biology News(10 mins):Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2
... to reduce sickness and death from infections that patients ... identifying ways to reduce the problem at its source. ... cubes or to rinse medical equipment is increasingly being ... contribute to many of these life-threatening infections. , Infection ...
... Commissioner Antonia C. Novello, M.D., M.P.H., Dr.P.H., today announced ... and Education campaign to help combat the potential spread ... virus that causes AIDS. , Dr. Novello said, "In ... strain of HIV in New York City, we must ...
... characteristic of diverse species of birds, but how this ... proves useful have remained uncertain. Researchers this week report ... bobbing is critical for the stabilization of their visual ... enables the accurate detection of objects such as food ...
Cached Biology News:Distributed Basic Local Alignment Search Toolkit (W.ND-BLAST) 2Distributed Basic Local Alignment Search Toolkit (W.ND-BLAST) 3AIDS Public Awareness Campaign Expands Following Report Of Rapidly Progressive HIV 2AIDS Public Awareness Campaign Expands Following Report Of Rapidly Progressive HIV 3Bobbing birds do it for a reason 2
(Date:8/4/2015)... , Aug. 4, 2015 Trigemina, Inc., a ... non-narcotic, nasally delivered, analgesic drug products, announced today that ... the position of chief medical officer. Dr. Kori brings ... much of which has been focused in the neuroscience ... add Dr. Kori to our clinical team given his ...
(Date:8/4/2015)... , ... August 04, 2015 , ... On August 4, ... a diverse selection of entrepreneurs from across the United States to talk about their ... is honored to be chosen to be among the attendees. , One of the ...
(Date:8/3/2015)... 2015 At the 11th hour, ... waved the shortfall of Jude Liversage,s campaign ... the first time.      (Photo: http://photos.prnewswire.com/prnh/20150803/254228 ... ) The Selective Dorsal Rhizotomy (SDR) procedure ... carry out his wish to kick a ball around ...
(Date:8/3/2015)... SAN DIEGO , Aug. 3, 2015  Aethlon Medical, ... affinity biofiltration devices to treat life-threatening diseases, today announced ... investor conference call and webcast on Thursday, August 13, ... call and webcast will follow the release of fiscal ... call will be available approximately two hours after the ...
Breaking Biology Technology:Trigemina Appoints Dr. Shashi Kori to the Position of Chief Medical Officer 2Trigemina Appoints Dr. Shashi Kori to the Position of Chief Medical Officer 3White House Invites uBiome CEO Jessica Richman to First-Ever Startup Demo Day 2Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 2Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 3Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2
... Imaging Diagnostic Systems, Inc., (OTC Bulletin Board: ... exhibit the CT Laser Mammography (CTLM(R)) system at the Arab ... Arab Emirates (UAE). The company will demonstrate the CTLM ... UAE and intends to secure prospective sales of the CTLM ...
... and consulting firm, Fadel Partners Inc., a certified partner ... year revenue growth of 13% for 2008, and expects ... company,s report stands in contrast to analyst estimates of ... U.S. IT services industry overall, as the economic downturn ...
... Development Program Has Been Approved For Second-Year Funding ... of the Chief Scientist-NES-ZIONA, Israel, Jan. 27 ... that its Israeli-based R&D subsidiary has received approval ... Office of the Chief Scientist ("OCS") in support ...
Cached Biology Technology:Imaging Diagnostic Systems Exhibits at Major Middle East Health Conference 2Fadel Partners Announces 13% Growth Despite IT Services Industry Downtrend 2Modigene Awarded Second-Year Grant by Israeli Government to Support Development of Its Longer-Acting Human Growth Hormone 2Modigene Awarded Second-Year Grant by Israeli Government to Support Development of Its Longer-Acting Human Growth Hormone 3Modigene Awarded Second-Year Grant by Israeli Government to Support Development of Its Longer-Acting Human Growth Hormone 4
Derlin-2 (C-18)...
CBF-B (G-2)...
Mouse monoclonal [164-12-2] to Ampicillin ( Abpromise for all tested applications)....
Flotillin-2 (ESA) Purified Anti-Mouse, Anti-Rat, Anti-Human, Anti-Dog, Anti-Chicken clone 29, Isotype Mouse IgG 1 , 150 µg Consult technical datasheet for details....
Biology Products: