Navigation Links
Small molecules found to protect cells in multiple models of Parkinson's disease
Date:12/28/2009

amage.

"Those two things are obviously related," says Pavan Auluck, first co-author and a visiting scientist in the Lindquist lab. "We're trying to figure out what the connections are between them. And there are a number of ways they can be related."

Lindquist agrees: "There are very deeply rooted processes that connect protein trafficking and mitochondrial viability," says Lindquist, who is also a Howard Hughes Medical Institute investigator and a professor of biology at MIT. "That emphasizes that the underlying problem caused by alpha-synuclein is a general cellular defect that is part of the machinery of all eukaryotic cells. The specific problems in Parkinson's are due to the neurons being particularly sensitive to that process going awry."

As for the future of the specific compounds identified in this study, Daniel Tardiff, a Lindquist postdoctoral researcher, remains optimistic.

"Theoretically if a compound is having a beneficial effect on yeast cells, and in a worm, and in primary neurons, then possibly through years and years of work, it might actually be a potential therapeutic avenue or drug," says Tardiff. "Though we started in yeast, one of those compounds could actually have some potential for human health in Parkinson's disease. That's always a lofty goal."


'/>"/>

Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Emerald BioStructures announces discovery of small molecule modulators of PDE4
2. Small changes in protein chemistry play large role in Huntingtons disease
3. Research yields new agent for some drug-resistant non-small cell lung cancers
4. Small addition to cancer drug may make big difference
5. Small nanoparticles bring big improvement to medical imaging
6. Small, beautiful and additive-free
7. Small mechanical forces have big impact on embryonic stem cells
8. Fate Therapeutics announces creation of small molecule platform for commercial-scale reprogramming
9. Conservation targets too small to stop extinction
10. Small molecule inhibits pathology associated with myotonic dystrophy type 1
11. Small rodents encourage the formation of scrubland in Spain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... NEW YORK CITY (September 22, 2014)The Brain ... the award of NARSAD Young Investigator ... to 200 of the world,s most promising ... grants for groundbreaking neurobiological research will seek ... prevention strategies for psychiatric disorders that affect ...
(Date:9/22/2014)... If you,re overweight, you may be at greater ... cardiovascular disease and cancer, according to a new ... that psychological stress can trigger biological responses similar ... inflammation. While normal inflammation is an important part ... contribute to chronic and life-threatening diseases. , ...
(Date:9/21/2014)... Mothers of children with autism are significantly less likely ... pregnancies than the mothers of children who are developing ... MIND Institute has found. , Low iron intake was ... the child if the mother was 35 or older ... she suffered from metabolic conditions such as obesity hypertension ...
Breaking Biology News(10 mins):Brain & Behavior Research Foundation awards 200 NARSAD Young Investigator grants 2Obesity and stress pack a double hit for health 2Mothers of children with autism less likely to have taken iron supplements 2
... received a $3.3 million contract from the U.S. Defense Advanced ... be so soft and squishy that they will be able ... morph back into something 10 times larger, and ultimately biodegrade. ... conduct dangerous or difficult operations are clear, and the U.S. ...
... essential hypertension also develop diabetes and other complications in ... discovered a common molecular mechanism in a strain of ... in mammals. , The bioengineering researchers at UC San ... drug developed for unrelated purposes in humans was effective ...
... Crohn,s disease researchers has combined data from three ... associated with the inflammatory bowel disorder, bringing the ... Several of these are involved with the immune ... that disruptions in a process called autophagy may ...
Cached Biology News:Tufts to develop morphing 'chemical robots' 2Tufts to develop morphing 'chemical robots' 3A single mechanism for hypertension, insulin resistance and immune suppression 2A single mechanism for hypertension, insulin resistance and immune suppression 3A single mechanism for hypertension, insulin resistance and immune suppression 4International team identifies 21 new genetic risk factors for Crohn's disease 2
(Date:9/22/2014)... 22, 2014 Research and ... of the "Global Biotechnology Reagents Market 2014-2018" ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) Biotechnology reagents are chemical ... system to detect and examine another substance to ... in laboratories to prepare, collect, and examine specimens ...
(Date:9/22/2014)... components developed by researchers at the USC Viterbi ... build a 3-D microfluidic system quickly and cheaply ... , Microfluidic systems are used in many ... manipulate small volumes of fluids for use in ... detection, clinical diagnostic testing, and synthetic chemistry. Traditionally, ...
(Date:9/22/2014)... Platelets, the tiny cell fragments whose job it is ... a cell nucleus. But they can "feel" the physical ... have discovered. , Platelets respond to surfaces with greater ... they "turn on" other platelets and other components of ... smarter than we give them credit for, in that ...
(Date:9/22/2014)... Analysis of circulating tumor cells (CTCs) in a mouse ... expression in several groups of CTCs, including significant differences ... ability to generate metastases. In their study reported ... , investigators from the Massachusetts General Hospital (MGH) Cancer ... found unexpected factors that may prove to be targets ...
Breaking Biology Technology:Global Biotechnology Reagents Market 2014-2018: Key Vendors are Agilent, BD Biosciences, Bio-Rad, F. Hoffmann-La Roche, Sigma-Aldrich and Thermo Fisher 2Global Biotechnology Reagents Market 2014-2018: Key Vendors are Agilent, BD Biosciences, Bio-Rad, F. Hoffmann-La Roche, Sigma-Aldrich and Thermo Fisher 3Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 2Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 3Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 4Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 5Platelets modulate clotting behavior by 'feeling' their surroundings 2Massachusetts General study reveals gene expression patterns in pancreatic CTCs 2Massachusetts General study reveals gene expression patterns in pancreatic CTCs 3
... 18 Caliper Life,Sciences, Inc. (Nasdaq: CALP ... Global Life Sciences Conference in New York City, ... 3:30 p.m. EDT. Kevin Hrusovsky, President,and CEO of ... company,s business.,The audio-only webcast can be accessed at, ...
... Cellectar, Inc., a,privately-held radiopharmaceuticals company that designs and ... today announced the,appointment of Charles C. Harwood, Jr., ... 55, is a Healthcare Industry Advisor for Avista ... working with Avista,Mr. Harwood was President and Chief ...
... 18 CJPS Enterprises, LLC, the,operator of the ... schedule available to Michigan companies interested in learning,about ... healthcare,industry. CJPS Enterprises, LLC (http://www.CJPS-Enterprises.com ) was ... (MEDC) as,part of the Life Sciences Pipeline initiative, ...
Cached Biology Technology:Charles C. Harwood, Jr., Joins Cellectar, Inc.'s Board of Directors 2The Michigan Life Sciences Pipeline Announces New Best Practices Seminars Tailored to Michigan Businesses 2
... For our novel expression vectors, we in-troduced ... dual controls: (i) at tran-scriptional level at the ... replication level by amplifying the plasmid copy number, ... is that it retains practically all of the ...
... is a new product number, created to ... no availability yet, please order under the ... service for assistance. Feature: tissue-culture ... area 21 cm 2 D ...
... allows you to store and manage very ... a secure central relational database. Storing and ... invaluable resource for clone tracking and enables ... immediate analysis. LabShare software integrates seamlessly with ...
... is the ultimate tool for investigating dynamic ... applications previously have been limited at wavelengths ... do not transmit in the deep UV. ... spectroscopy, introduces a filter-based confocal system (the ...
Biology Products: