Navigation Links
Small molecules can starve cancer cells
Date:10/8/2011

All cells in our body have a system that can handle cellular waste and release building blocks for recycling. The underlying mechanism is called autophagy and literally means "self-eating". Many cancer cells have increased the activity of this system and the increased release of building blocks equip the cancer cells with a growth advantage and can render them resistant towards treatment.

"We have discovered a small molecule that can block autophagy in different cancer cells and specifically, this molecule can increase the sensitivity of breast cancer cells towards one of the most commonly used treatments for breast cancer," says Professor Anders H. Lund, at BRIC, University of Copenhagen.

The results have just been published in EMBO Journal: "microRNA-101 is a potent inhibitor of autophagy, Frankel et al."

The molecule that the researchers have studied is called microRNA-101 and is found naturally in our cells. In cancer research, there is currently a large focus on both autophagy and microRNA molecules, which can control our genes and both mechanisms are known to play an important role for cancer development.

"We have shown that microRNA-101 can turn off specific genes and thereby inhibit autophagy in cancer cells. The fact that microRNA molecules can regulate autophagy is quite new and our results disclose a large and interesting field within cancer research" says researcher Lisa Frankel, who has been leading this research project in Anders H. Lund's laboratory.

MicroRNA-101 is often lost in liver cancer, prostate cancer and breast cancer. By controlling the level of microRNA-101 in cells of different cancer types, the researchers from BRIC show that microRNA-101 regulates autophagy. In addition, the researchers have shown that breast cancer cells become more sensitive towards treatment with the anti-hormone Tamoxifen, when they via microRNA-101 turn off the autophagy system.

"This result has a clear clinical relevance, as resistance against tamoxifen is a large problem in the treatment of breast cancer," says Anders H. Lund.

The next step of the researchers is to investigate whether other microRNA molecules are involved in the regulation of autophagy in cancer cells. Further, they will take a closer look at the role of microRNA-101 in normal development of our organism and in the development of cancer.


'/>"/>

Contact: Anders H. Lund
anders.lund@bric.ku.dk
01-145-306-62303
University of Copenhagen
Source:Eurekalert

Related biology news :

1. UNC spin-off receives $3 million Small Business Innovation Research Grant
2. Small fish recover faster than large fish
3. Small bowel transplant, Crohns experts from around the world hosted by Georgetown
4. Small molecule receptor detects lipids telltale sign of cell death
5. Office of Naval Research looks for big opportunities at small business conference
6. Small molecules shed light on cancer therapies
7. Disordered networks synchronise faster than small world networks
8. Sneaky squid: Why small males have big sperm
9. TREW Marketing Introduces Smart Marketing for Engineers, a Free Guidebook for Small Businesses Targeting Technical Audiences
10. Study shows small-scale fisheries impact on marine life
11. Being small has its advantages, if you are a leaf
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)... , May 5, 2017 ... just announced a new breakthrough in biometric authentication ... exploits quantum mechanical properties to perform biometric authentication. These ... smart semiconductor material created by Ram Group and ... finance, entertainment, transportation, supply chains and security. Ram ...
(Date:4/19/2017)... , April 19, 2017 The ... vendor landscape is marked by the presence of several ... however held by five major players - 3M Cogent, ... companies accounted for nearly 61% of the global military ... companies in the global military biometrics market boast global ...
(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... DALLAS , Oct. 10, 2017 International research firm ... IoT Strategy, will speak at the TMA 2017 Annual Meeting , ... key trends in the residential home security market and how smart safety ... ... "The ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM ... firm for the life sciences and healthcare industries, announces a presentation by Subbu ... , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present a ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings ... mechanism by which its ProCell stem cell therapy ... limb ischemia.  The Company, demonstrated that treatment with ... of limbs saved as compared to standard bone ... molecule HGF resulted in reduction of therapeutic effect.  ...
(Date:10/9/2017)... Charlotte, N.C. (PRWEB) , ... October 09, 2017 , ... ... Purple announced Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and ... Dr. Stubbs was a member of the winning team for the 2015 Breakthrough Prize ...
Breaking Biology Technology: