Navigation Links
Small molecule receptor detects lipid's telltale sign of cell death
Date:9/12/2011

CHESTNUT HILL, MA (9/13/2011) Researchers from Boston College have developed a new class of small molecule receptors capable of detecting a lipid molecule that reveals the telltale signs of cellular death, particularly cancer cells targeted by anti-cancer drugs, the team reports in the current electronic edition of the Journal of the American Chemical Society.

Researchers led by Assistant Professor of Chemistry Jianmin Gao successfully grafted the key residues of the milk protein lactadherin onto the molecular scaffolding of a short but sturdy circular chain of amino acids to create cyclic lactadherin (cLac) mimics capable of binding to apoptotic, or dying, cells.

Gao said his team spent a year and a half focused on a finding a new method of measuring cell death. The team wanted to create an alternative to traditional tests that measure whether or not a tumor has shrunk in size after several weeks of treatment. The team's focus was on finding a way to measure the presence of dead cells, not the absence of tumor cells.

"We started by looking for a method to detect dying cells," said Gao. "The sensitivity of scientific and medical imaging is better if you look for the appearance of something, rather than the disappearance. What we wanted to look for is that in the initial stages of treatment the therapy's molecules are beginning to trigger the death of cancer cells. That can give you an idea a drug is working much sooner than the current methods of evaluation."

The newly engineered cLac molecules could prove useful as a prognostic tool which could enable oncologists to determine the effectiveness of anti-cancer drugs in a matter of days rather than several weeks, said Gao, who added that further research and testing will need to be conducted.

"Given the small size and ease of synthesis and labeling, cLacs hold great promise for noninvasive imaging of cell death in living animals and, ultimately, in human p
'/>"/>

Contact: Ed Hayward
ed.hayward@bc.edu
617-552-4826
Boston College
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Office of Naval Research looks for big opportunities at small business conference
2. Small molecules shed light on cancer therapies
3. Disordered networks synchronise faster than small world networks
4. Sneaky squid: Why small males have big sperm
5. TREW Marketing Introduces Smart Marketing for Engineers, a Free Guidebook for Small Businesses Targeting Technical Audiences
6. Study shows small-scale fisheries impact on marine life
7. Being small has its advantages, if you are a leaf
8. Researchers engineer functioning small intestine in laboratory experiments
9. Treatment approach to human Usher syndrome: Small molecules ignore stop signals
10. Transport Phenomena and Membrane Digestion in Small Intestinal Mucosa by Pensoft
11. Oceans harmful low-oxygen zones growing, are sensitive to small changes in climate
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Small molecule receptor detects lipid's telltale sign of cell death
(Date:10/14/2014)... JOLLA, CA – October 14, 2014 – Scientists from ... million from the National Institutes of Health (NIH) to ... prevalent virus-induced hemorrhagic fever disease in Africa. The study ... and why some patients die, while others survive the ... to understand the basic mechanism of how Lassa fever ...
(Date:10/14/2014)... an international team of researchers, led by the Chinese ... journal Nature Genetics a brief genomic history ... of the tomato plant. , The C.M. Rick Tomato ... role in this study by providing seed of both ... study, which builds on the first tomato genome sequence ...
(Date:10/14/2014)... – Over the past decades, we have seen numerous ... the needs of infants for social contact and stimulation ... thrive. , Infancy and childhood are critical ... A generation of research suggests that enriched environments, full ... cognitive function. In contrast, deprivation and stress may compromise ...
Breaking Biology News(10 mins):Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2Institutional rearing may increase risk attention-deficit disorder 2
... research team coordinated at the IRCM in Montral found ... Dr. Tarik Mry, the IRCM,s President and Scientific Director, ... "Achilles, heel" and could be targeted to develop a ... current treatments such as chemotherapy and radiation therapy. The ...
... common element but is found in old paints (including ... water, and the atmosphere from lead-containing vehicular fuels, even ... also causes seemingly trivial symptoms such as headaches. However, ... to the organs, the kidneys in particular, and the ...
... prostate cancer is the most common cancer in elderly ... aged between 35 and 50. Scientists at the European ... with several other research teams in Germany*, have discovered ... different mechanism from that which causes the disease at ...
Cached Biology News:Researchers discover 'Achilles' heel' for lymphoid leukemia 2Is lead poisoning behind some juvenile crime? 21 disease, 2 mechanisms 2
(Date:10/17/2014)... Germany , October 17, 2014 /PRNewswire/ ... research in cancer and other diseases will benefit ... Society of Human Genetics annual meeting   ... Ingenuity ®  Knowledge Base greatly exceeds any comparable ... Ingenuity ®  Variant Analysis™ adds fully integrated BIOBASE ...
(Date:10/17/2014)... The Europe Fuel Additives Market report ... with analysis and forecast of revenue. , Browse through ... to get an idea of the in-depth analysis provided. ... the European fuel additives market, and is supported by ... , Fuel additives are chemicals that are used to ...
(Date:10/17/2014)... The report “Feed Antioxidants Market by Type (BHA, ... Aquatic Animals & Others), by Geography - Global Trends ... feed antioxidant market with analyses and projection of the ... feed antioxidants. , The global market for feed antioxidants, ... around $191.1 million in 2013 and is projected to ...
(Date:10/17/2014)... The report "Thermocouples and High End ... Petrochemical, Consumer Utility, Glass, and Aerospace & Defense) ... Analysis & Forecast to 2010 - 2020", defines ... pyrometer market into various sub-segments with an in-depth ... the drivers and restraints for this market with ...
Breaking Biology Technology:QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 3QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 4QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 5QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 6The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 2The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 3The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 4Feed Antioxidants Market Projected To Reach $238.5 Million by 2018 - New Report by MarketsandMarkets 2Feed Antioxidants Market Projected To Reach $238.5 Million by 2018 - New Report by MarketsandMarkets 3Feed Antioxidants Market Projected To Reach $238.5 Million by 2018 - New Report by MarketsandMarkets 4Thermocouples Market Growing at CAGR of 3.70% & High End Optical Pyrometers Market Growing at CAGR of 13.81% - New Report 2Thermocouples Market Growing at CAGR of 3.70% & High End Optical Pyrometers Market Growing at CAGR of 13.81% - New Report 3Thermocouples Market Growing at CAGR of 3.70% & High End Optical Pyrometers Market Growing at CAGR of 13.81% - New Report 4
... the Project on Emerging Nanotechnologies (PEN) at the ... variety of voluntary options available for the oversight ... Voluntary Initiatives, Regulation, and Nanotechnology Oversight: Charting a ... Center for Environmental Policy at American University, provides ...
... content="bioMerieux and Biocartis Sign Strategic Partnership in Molecular Diagnostics. Co-development of ... launch in 2012,bioMerieux gains exclusive rights in microbiology,bioMerieux takes equity stake ... in Molecular... -- MARCY L,ETOILE, France and LAUSANNE, Switzerland, Nov. 4, ... ...
... Novavax, Inc. (Nasdaq: NVAX ) announced ... grants under the Internal Revenue Service,s Qualifying Therapeutic Discovery ... Protection and Affordable Care Act of 2010 to provide ... of eligible qualified investments in therapeutic discovery projects during ...
Cached Biology Technology:bioMerieux and Biocartis Sign Strategic Partnership in Molecular Diagnostics 2bioMerieux and Biocartis Sign Strategic Partnership in Molecular Diagnostics 3bioMerieux and Biocartis Sign Strategic Partnership in Molecular Diagnostics 4bioMerieux and Biocartis Sign Strategic Partnership in Molecular Diagnostics 5bioMerieux and Biocartis Sign Strategic Partnership in Molecular Diagnostics 6bioMerieux and Biocartis Sign Strategic Partnership in Molecular Diagnostics 7bioMerieux and Biocartis Sign Strategic Partnership in Molecular Diagnostics 8bioMerieux and Biocartis Sign Strategic Partnership in Molecular Diagnostics 9
...
... Detection Kit is intended for quantitative detection ... peptides, which can result from the gradual, ... aspartic acid residues during storage or handling. ... the monitoring of charge differences for detection, ...
...
...
Biology Products: