Navigation Links
Small molecule receptor detects lipid's telltale sign of cell death
Date:9/12/2011

CHESTNUT HILL, MA (9/13/2011) Researchers from Boston College have developed a new class of small molecule receptors capable of detecting a lipid molecule that reveals the telltale signs of cellular death, particularly cancer cells targeted by anti-cancer drugs, the team reports in the current electronic edition of the Journal of the American Chemical Society.

Researchers led by Assistant Professor of Chemistry Jianmin Gao successfully grafted the key residues of the milk protein lactadherin onto the molecular scaffolding of a short but sturdy circular chain of amino acids to create cyclic lactadherin (cLac) mimics capable of binding to apoptotic, or dying, cells.

Gao said his team spent a year and a half focused on a finding a new method of measuring cell death. The team wanted to create an alternative to traditional tests that measure whether or not a tumor has shrunk in size after several weeks of treatment. The team's focus was on finding a way to measure the presence of dead cells, not the absence of tumor cells.

"We started by looking for a method to detect dying cells," said Gao. "The sensitivity of scientific and medical imaging is better if you look for the appearance of something, rather than the disappearance. What we wanted to look for is that in the initial stages of treatment the therapy's molecules are beginning to trigger the death of cancer cells. That can give you an idea a drug is working much sooner than the current methods of evaluation."

The newly engineered cLac molecules could prove useful as a prognostic tool which could enable oncologists to determine the effectiveness of anti-cancer drugs in a matter of days rather than several weeks, said Gao, who added that further research and testing will need to be conducted.

"Given the small size and ease of synthesis and labeling, cLacs hold great promise for noninvasive imaging of cell death in living animals and, ultimately, in human p
'/>"/>

Contact: Ed Hayward
ed.hayward@bc.edu
617-552-4826
Boston College
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Office of Naval Research looks for big opportunities at small business conference
2. Small molecules shed light on cancer therapies
3. Disordered networks synchronise faster than small world networks
4. Sneaky squid: Why small males have big sperm
5. TREW Marketing Introduces Smart Marketing for Engineers, a Free Guidebook for Small Businesses Targeting Technical Audiences
6. Study shows small-scale fisheries impact on marine life
7. Being small has its advantages, if you are a leaf
8. Researchers engineer functioning small intestine in laboratory experiments
9. Treatment approach to human Usher syndrome: Small molecules ignore stop signals
10. Transport Phenomena and Membrane Digestion in Small Intestinal Mucosa by Pensoft
11. Oceans harmful low-oxygen zones growing, are sensitive to small changes in climate
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Small molecule receptor detects lipid's telltale sign of cell death
(Date:5/11/2015)... a well-rounded UAS delegation representing private industry, government, and academia, ... AUVSI,s Unmanned 2015 conference last week in Atlanta ... UAS industry met with over 200 hundred people from companies ... ecosystem. "Our message is clear and consistent," ... Rich Knoll . "If you want to fly UAS, you ...
(Date:5/6/2015)... TEL AVIV, Israel , May 6, 2015 /PRNewswire/ ... the world,s most established helmet producer, announced today that ... LifeBEAM Smart Helmet, the world,s first bio-sensing cycling helmet ... will be released in two new colors in order ... demand for the product. In addition, LifeBEAM and Lazer ...
(Date:4/21/2015)... 21, 2015 High crime ... are boosting access control systems market in ... a recently published report by TechSci Research " Saudi ... access control systems market in Saudi Arabia ... 2020.The access control systems market in the Kingdom is ...
Breaking Biology News(10 mins):Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... Scientists know more today than ever before about the microbes ... fact, that gathering all of the relevant bits of information ... in itself. Now, grantees of the National Institute of ... of Health, and their international colleagues intend to solve this ...
... of Michigan researchers are investigating a radical new design ... water-filled compartments that enable non-native creatures to sneak into ... non-native aquatic species have been identified in the Great ... of most---including the notorious zebra and quagga mussels and ...
... actions and dispositions of strangers by observing others ... show an ability to recognize certain behavioral traits ... of these traits in strangers in similar situations ... from the George Washington University in Washington DC ...
Cached Biology News:Scientists launch first comprehensive database of human oral microbiome 2Scientists launch first comprehensive database of human oral microbiome 3U-M 'ballast-free ship' could cut costs while blocking aquatic invaders 2U-M 'ballast-free ship' could cut costs while blocking aquatic invaders 3Who's bad? Chimps figure it out by observation 2
(Date:5/25/2015)... Aviv, Israel (PRWEB) May 25, 2015 ... analytics software provider, announced the availability, beginning May ... The new version of Phenome One solidifies Phenome Networks’ ... user interface supporting a simple and intuitive breeding workflow ... performance; the ability to customize field design, and more. ...
(Date:5/22/2015)... Warren, NJ (PRWEB) May 22, 2015 ... a new white paper that explores the potential of ... industries. The white paper was developed to help life ... they can leverage data to gain critical business insights. ... generated large amounts of data driven by patient profiling, ...
(Date:5/21/2015)... 21, 2015 Specialty Pharmacy Times ... been admitted to BPA Worldwide as a business ... track audience data for Specialty Pharmacy Times based ... “By becoming a member of BPA Worldwide, Specialty ... our clients with the most reliable, unequaled data,” ...
(Date:5/21/2015)... NOVATO, Calif. , May 21, 2015 /PRNewswire-USNewswire/ ... Orrin Hatch (R-UT) and Amy ... Product Extensions Now Accelerating Cures & Treatments, or ... 150 rare disease patient advocacy organizations, this bipartisan ... effective, and affordable medicines to rare disease patients ...
Breaking Biology Technology:Phenome Networks Announces its Next Generation Plant Breeding Management and Analytics Software 2Phenome Networks Announces its Next Generation Plant Breeding Management and Analytics Software 3New White Paper Explores the Potential of Big Data Analytics in Life Sciences and Healthcare 2Specialty Pharmacy Times Joins BPA Worldwide 2Advocates Cheer Senate Leaders for Introducing Bipartisan Bill to Increase Number of Rare Disease Treatments 2
... Milwaukee, Wis. - Marshfield ... clinical information management software developed by TeraMedica ... product, known as Evercore, will be deployed to ... and non-medical images, then distribute them within the ...
... Wis . - Alex Vodenlich believes his life-science company, ... acquisition of a protein chip platform from GlaxoSmithKline , ... which the technology improves the quality of data GenTel delivers ... chip used by cancer researchers, announced the acquisition during an ...
... In a move to strengthen its ability to fight ... has acquired NetEconomy , a financial crime management ... Netherlands. , ,Financial terms of the acquisition were not ... applications for anti-money laundering, fraud prevention, and compliance. Those ...
Cached Biology Technology:GenTel acquires GlaxoSmithKline chip platform 2GenTel acquires GlaxoSmithKline chip platform 3
Coating : Poly-D-Lysine ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vol working : 2.5-3.0 ml ...
BD BioCoat Collagen IV 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse collagen type IV....
BD BioCoat Matrigel Matrix 35 mm Culture Dishes Coating : BD MatrigelTM Basement Membrane Matrix ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vo...
... Compatible with AutoGen AutoGenesys, BioRobotics BioPick, BioGrid, ... colony picking systems This CLS number is ... match Cornings product number. If showing no ... Sigma-Aldrich number (D9314) or contact customer service ...
Biology Products: