Navigation Links
Small genetic variant can predict response to hepatitis C treatment
Date:6/12/2010

nd condition as well as why they might react or not to therapy for it. In this case, approximately half of the patients studied had responded successfully to therapy, giving the scientists the opportunity to compare their genomes with those from patients who had not responded.

"Using a gene-chip technology, a team of clinicians, geneticists and statisticians looked at over one million polymorphic nucleotides, the letters A, C, G and T of the DNA sequence", said Dr. Kutalik. "Our analysis revealed that a single nucleotide polymorphism, or SNP, was present in a gene called IL28B, which encodes for interferon lambda. This was significantly associated with both natural and drug-induced clearance of the hepatitis C virus from the body. This polymorphism may exert its influence by modulating the expression level of the interferon lambda gene."

Individuals who carry the protective allele (letter) at this genetic locus are twice as likely to clear the virus and, even if they do not, they will respond to therapy in a sustained manner; the scientists say. "Individuals infected with the less malignant subtype of the virus and carrying no risk allele were five times more likely to respond than those who were infected with other subtypes and who carried at least one copy of the risk allele. Based on our results we can speculate that the interferon lamda gene is key to increasing the success of therapy, as such therapy could, in theory, compensate for the effect of the polymorphism. Phase 1B trials of interferon lamda therapy in patients with hepatitis C have already shown promising results", Dr. Kutalik said.

The scientists intend to follow up their work by focusing on a better understanding of the more complex characteristics of hepatitis C, including finding the genetic variants that are responsible for hepatitis C liver fibrosis. "This disease affects up to 300 million people worldwide. It is insidious, and often individuals are not awar
'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
European Society of Human Genetics
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers discover new mechanism for clearing blockages from smallest blood vessels
2. Small mammals -- and rest of food chain -- at greater risk from global warming than thought
3. Even small patches of urban woods are valuable for migrating birds
4. EPA awards small businesses to develop new environmental technologies
5. UCLA researchers show how worlds smallest coffee ring may help biosensors detect disease
6. Weird, ultra-small microbes turn up in acidic mine drainage
7. Moffitt Cancer Center: Growing interest in prognostic test for non-small cell lung cancer
8. Bacterial food supplements for small algae
9. Study finds that low-income women living in small cities have higher chance of obesity
10. University of Minnesota scientist finds that big plant seeds dont always beat out small seeds
11. Lifes smallest motor, cargo carrier of the cells, moves like a seesaw
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... a group of fish began exploring land and evolved into ... how these ancient fish used their fishy bodies and fins ... play remain scientific mysteries. , Researchers at McGill University ... living fish, called Polypterus , to help show what ... of the water. Polypterus is an African fish ...
(Date:8/27/2014)... An invasive grass species frequently found in forests has ... feed on American toads, a new University of Georgia ... introduced to the U.S. in the early 1900s, is ... spread to more than a dozen states in the ... roads and in forests, it can survive in widely ...
(Date:8/27/2014)... /PRNewswire-iReach/ -- The IEEE Engineering in Medicine and Biology ... International Conference (EMBC,14), this year being held at the ... Illinois , from Tuesday, August 26 through Saturday, ... industry professionals in science, medicine, and engineering are registered ... This year,s conference theme is ...
Breaking Biology News(10 mins):Walking fish reveal how our ancestors evolved onto land 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 3Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 2Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 3
... N.Y. (September 30, 2010) Autism Speaks is pleased ... Fellows. Made possible by a multi-year grant from the ... Morgan CEO Sir Dennis Weatherstone, eight fellowship projects were ... $448,000 over the next two years. The fellowship awards ...
... Iowa - An Iowa State University researcher searched for ... a type of mosquito that is not only a ... professor of entomology, along with colleagues from around the ... quinquefasciatus ) with various pathogens to see which mosquito ...
... will award up to $64 million over five years ... ideas that have the potential for extraordinary impact. ... program allows investigators to sidestep conventional stumbling blocks they ... such as the need for preliminary data or a ...
Cached Biology News:Autism Speaks awards second class of Dennis Weatherstone pre-doctoral fellowships 2Autism Speaks awards second class of Dennis Weatherstone pre-doctoral fellowships 3Iowa State University researcher examines mosquito gene for new disease response 2
(Date:8/27/2014)... WriteResult, LLC – a premier provider of ... superiority when it comes to meeting the needs of ... of their most recent study closeout on-time and with ... digital writing platform to collect Patient Reported Outcomes electronically ... drew data from a number of assessments including the ...
(Date:8/26/2014)... what they believe is the thinnest-possible semiconductor, a ... only three atoms thick. , The University of ... single-layer semiconductor materials can be connected in an ... result could be the basis for next-generation flexible ... and solar technologies. , "Heterojunctions are fundamental elements ...
(Date:8/26/2014)... Diego, CA, and Bellingham, WA (PRWEB) August 26, ... and optical engineering, visions for next-generation wearable technology, ... 2015 among numerous highlights at this year’s brighter, ... the San Diego, California, Convention Center. More than ... last week attended conferences, courses, an exhibition, and ...
(Date:8/26/2014)... (PRWEB) August 26, 2014 The 20 ... of ALS (YFALS) community issued the following statement on ... bringing awareness and driving new funding specifically for ALS ... of water and some ice would raise all this ... with our families, and on behalf of the entire ...
Breaking Biology Technology:A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2Scientists craft atomically seamless, thinnest-possible semiconductor junctions 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 3ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 4
... Peterson, president and CEO of ZyStor Therapeutics, Inc. ... for attendees of this year's Midwestern bioscience forum. , ... Wisconsin biotechnology companies with another presenter, Dr. Irene Hrusovsky, ... of molecular diagnostic products. , ,Like many of the ...
... engine optimization (SEO) tactics have one thing in common: ... and incorporating them into a web site, marketers can ... a desirable search engine ranking requires good information about ... website's industry or topic. A good place to start ...
... - CDW Corp. , a $6 billion-a-year information technology ... agreed to acquire the stock of Madison-based Berbee Information ... ,The acquisition, which has been approved by the boards of ... October, subject to regulatory approvals and approval by Berbee shareholders. ...
Cached Biology Technology:ZyStor to exhibit cell disorder treatments 2Search engine optimization: What's the word? 2Search engine optimization: What's the word? 3Berbee believes acquisition by CDW will make it a national IT player 2Berbee believes acquisition by CDW will make it a national IT player 3
... is the industry standard microarray image analysis ... imaging and analysis tools, visualizations, automation capabilities, ... is included with every GenePix scanner, and ... scanners and all types of arrays. A ...
... is the ideal instrument for budget-conscious labs that ... applications. Get Applied Biosystems proven PCR ... lab space without sacrificing results. Enhance ... Technology You Can Afford The Applied ...
... synthesis with a wide variety of purity levels, ... needs. Purity: IG(>50%), >70%, >80% ... Sequence Length: Up to 120 residues ... phosphorylation, D-amino acids, MAPs, KLH/BSA conjugation, and much ...
... The AquaMax DW4 liquid handling system from ... washing all in one instrument. The system ... dispensing and plate washing96-, 384- and 1536-welland ... washing. AquaMax DW4 has been optimized to ...
Biology Products: