Navigation Links
Small genetic variant can predict response to hepatitis C treatment
Date:6/12/2010

Gothenburg, Sweden: A small genetic change can predict how people infected with hepatitis C react to treatment, paving the way to personalised therapy for this difficult to treat disease, the annual conference of the European Society of Human Genetics will hear today (Sunday 13 June). Dr. Zoltan Kutalik, from the Department of Medical Genetics, University of Lausanne, Switzerland, will tell delegates that individuals with this change, in a gene encoding for the antiviral cytokine (cell-signalling molecule) interferon lamda, reacts less well to treatment. This knowledge could spare them the unpleasant side effects of a therapy which most likely would have little benefit for them, he says.

Hepatitis C is a serious liver disease, normally contracted through drug use, blood transfusion or sexual transmission. About 10% of all patients have no identifiable source of infection. The virus produces chronic infection in around 80% of infected individuals, and half of these do not respond to existing therapies. Current treatment involves a combination of an interferon and the antiviral medication ribavirin. Side effects are common and can be serious to the extent that some people are unable to continue to work.

The fact that people respond so differently to the same treatment is usually because a genetic variation in the non-responders is, via complex genetic pathways, inhibiting the effects of therapy. "The Lausanne University Hospital (CHUV) has a large cohort of Hepatitis C patients seen at the hospital over many years", said Dr. Kutalik, "so this provided the opportunity for us to do a genome-wide association study on 1362 of them to see if we could track down any differences relating to patients' failure to respond to therapy."

Genome-wide association studies look at variations across the entire genome of individuals to look for genetic associations with well-defined traits, including why some people get a particular disease a
'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
European Society of Human Genetics
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Researchers discover new mechanism for clearing blockages from smallest blood vessels
2. Small mammals -- and rest of food chain -- at greater risk from global warming than thought
3. Even small patches of urban woods are valuable for migrating birds
4. EPA awards small businesses to develop new environmental technologies
5. UCLA researchers show how worlds smallest coffee ring may help biosensors detect disease
6. Weird, ultra-small microbes turn up in acidic mine drainage
7. Moffitt Cancer Center: Growing interest in prognostic test for non-small cell lung cancer
8. Bacterial food supplements for small algae
9. Study finds that low-income women living in small cities have higher chance of obesity
10. University of Minnesota scientist finds that big plant seeds dont always beat out small seeds
11. Lifes smallest motor, cargo carrier of the cells, moves like a seesaw
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... The tight wrapping of genomic DNA around nucleosomes ... gene expression. A team of Ludwig-Maximilians-Universitaet (LMU) in ... DNA to be locally displaced from nucleosomes for ... is stored in the cell nucleus, wrapped around ... pairs of four different histone proteins and accommodating ...
(Date:5/23/2013)... 2013) A new report from the Institute of ... engage in at least 60 minutes of vigorous or ... more than half of American youth meet current evidence-based ... moderate intensity physical activity daily, according to the report, ... in school for nearly half of their waking hours, ...
(Date:5/23/2013)... Frontiers, one of the world,s largest and fastest ... new journal, Frontiers in Bioengineering and Biotechnology ... all specialties, Frontiers in Bioengineering and Biotechnology ... diverse and emerging bioengineering and biotechnology research to ... in Bioengineering and Biotechnology will provide an ...
Breaking Biology News(10 mins):Biochemistry: Unspooling DNA from nucleosomal disks 2Schools should provide students with daily physical activity, IOM recommends 2Frontiers launches new open-access journal in Bioengineering and Biotechnology 2
... have determined the atomic structure of the ,binding, between ... key to treating patients with diseases such as variant ... a family of rare progressive neurodegenerative disorders, called prion ... thought that those who have developed vCJD became infected ...
... Sea the deepest point on Earth are ... according to Shahrazad Abu Ghazleh and colleagues from the ... Sea-Red Sea or Mediterranean-Dead Sea Channels therefore need a ... its former level, in order to sustainably generate electricity ...
... antiretroviral drugs in hair samples taken from HIV patients ... findings, published in the February 20 issue of ... in the hair of patients on treatment correlated strongly ... "High levels of antiretrovirals in hair correlated with ...
Cached Biology News:Antibody key to treating variant CJD, scientists find 2Is the Dead Sea dying? 2Using hair to manage HIV/AIDS and predict treatment success 2Using hair to manage HIV/AIDS and predict treatment success 3
(Date:5/24/2013)... Vestiage, Inc. (stock symbol "VEST") a publicly ... and development, sales and marketing of premium branded ... that it is awarding exclusive Vestiage territories in ... Skin Illuminating Facial Care. Qualified applicants can request ... email to info(at)vestiageinc(dot)com and putting RELUMA in the ...
(Date:5/23/2013)... , May 23, 2013  BioScrip, Inc. (NASDAQ: ... will present at the Jefferies 2013 Global Healthcare Conference ... Hyatt New York. Richard Smith ... Hai Tran , Chief Financial Officer, will ... Eastern Daylight Time.   About BioScrip ...
(Date:5/23/2013)... 2013  Rahal Letterman Lanigan Racing (RLL) and StemCyte, ... cell banking and therapeutics, announced today that StemCyte has ... Stairlifts Indy car driven by James Jakes ... IZOD IndyCar 2013 season.   StemCyte, Inc. and ... awareness of umbilical cord blood banking and its educational ...
(Date:5/23/2013)... , May 23, 2013 Virobay, Inc. today ... pain has reached an important milestone, as Virobay has ... - a selective cathepsin S inhibitor.   ... double-blind, randomized, placebo-controlled study designed to evaluate the safety, ... in healthy adults. "The initiation of this ...
Breaking Biology Technology:Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 2Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 3Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 4Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 5StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 2StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 3Virobay, Inc. initiates a Phase 1 Trial of VBY-036, a compound intended for the treatment of neuropathic pain 2Virobay, Inc. initiates a Phase 1 Trial of VBY-036, a compound intended for the treatment of neuropathic pain 3
... high-tech economy has yet to hit its growth spurt ... executives, Madison has what it takes to support a ... as successful as other regions? , , Accelerate Madison ... business climate through information technology, hosted a forum to ...
... Im not a big Bob Dylan fan, but lately I ... in the Wind" in which he questions mans inability ... , ,Dylans lyrics come to mind whenever the media starts ... business reengineering was all the rage. Anyone hesitating to reengineer ...
... an ancient and proud history of interstate sports rivalries ... like this past New Years Day, the rivalry generates ... and marijuana have in common? They both get smoked ... fomenting another interstate rivalry. This one is of keen ...
Cached Biology Technology:Tech Business Leaders Compare Madison to Other Regions 2Tech Business Leaders Compare Madison to Other Regions 3Tech Business Leaders Compare Madison to Other Regions 4Offshore Outsourcing: On Target or Off Base? 2Offshore Outsourcing: On Target or Off Base? 3For Now, Michigan Can Celebrate $150 Million Entrepreneurial VC Fund 2For Now, Michigan Can Celebrate $150 Million Entrepreneurial VC Fund 3For Now, Michigan Can Celebrate $150 Million Entrepreneurial VC Fund 4
Anti-Phospho-JKK/SEK1/MKK4 pAb Description: 100 g rabbit polyclonal antibody. Reacts with human/mouse/rat. Tested in WB. Research Focus: signal transduction Storage: -20C Shipping Tem...
... A - Fixation medium Reagent B - ... for fixing cells in suspension with Reagent ... Reagent B. This procedure gives antibodies access ... scatter characteristics of the cells intact. Specific ...
... Vision Mount is formulated for covering tissue sections and ... alcohol insoluble end products. , ... ... as Fast-Red or AEC that require an aqueous mounting medium, ...
... Retrieval Solution, High pH This pH ... retrievel prior to immunohistochemical staining procedures. It ... sections mounted on glass slides. For particular ... is especially effective. It should be noted ...
Biology Products: