Navigation Links
Small RNAs can play critical roles in male infertility/contraception
Date:4/9/2009

RENO, Nev. University of Nevada School of Medicine scientists in the Department of Physiology and Cell Biology have discovered insight into the reproductive workings of the male sex chromosome that may have significant implications for male infertility and contraception.

This important discovery has been published in Nature Genetics, one of the highest-ranking journals in the field of biomedical research based upon the impact factor.

The study findings indicate that the X chromosome in developing sperm cells encodes numerous tiny ribonucleic acids called microRNAs despite the fact that that most of genes on the X chromosomes are suppressed. This unprecedented observation implies that these small RNAs have critical roles in chromosome inactivation and also in sperm formation.

"The sex chromosome silencing in meiotic male germ cells is a well-known phenomenon, which has been termed meiotic sex chromosome inactivation. I was surprised when we first observed that numerous microRNAs were highly expressed in these cells," said Wei Yan, M.D., Ph.D., principal investigator for the study and associate professor of physiology and cell biology at the School of Medicine.

Working in collaboration with Dr. John McCarrey, professor of molecular biology and reproductive biology at the University of Texas, San Antonio, Yan's research group further investigated all the known X-linked microRNAs. Their data confirm that these X chromosome-derived microRNAs indeed escape the silencing effects and mange to be expressed.

"This finding opens a new avenue towards understanding the role of these small RNA species in the control of sperm production. Worldwide, one in nine couples in their reproductive age experience infertility. On the other hand, the number of unintended pregnancy is increasing yearly. Since these small RNAs are involved in the control of sperm formation, th
'/>"/>

Contact: Anne McMillin
amcmillin@medicine.nevada.edu
University of Nevada, Reno
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scientists at CSHL discover mobile small RNAs that set up leaf patterning in plants
2. Small molecules block cancer gene
3. Freezing kidney cancer: Hot treatment should be new gold standard for destroying small tumors
4. Scientists at CSHL discover mobile small RNAs that set up leaf patterning in plants
5. Vanderbilt scientists invent worlds smallest periscopes
6. Nanoparticle toxicity doesnt get wacky at the smallest sizes
7. Small male chimps use politics, rather than aggression, to lead the pack, U of Minnesota study says
8. CSHL scientists find a new class of small RNAs and define its function
9. Small changes can lead to big rewards, says ASN president
10. New study indicates smallpox vaccination effective for decades
11. Small satellite takes on large thunderstorms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Small RNAs can play critical roles in male infertility/contraception
(Date:12/17/2014)... 16, 2014  Automation is fundamentally transforming the ... than at international borders. Over the past decade, ... allowed veteran travelers to self process through border ... Kiosks at an increasing number of airports, seaports, ... According to Maxine Most , Principal ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced ... the APAC Region 2015-2019"  report to their offering. ... this market is advances in technology. With continuous ... biometric solutions to the latest standard that meets ...
(Date:12/11/2014)... -- That blood pressure plays a role in human health has ... term for high blood pressure – was first described as ... that,s used in measuring blood pressure was invented in 1896. ... hypertension, its triggers and its effects. In fact, recent findings ... best ways to treat it. For example, a ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... a range of free, multi-media resources to update the study ... genetics research have leapt from sequencing the human genome over ... a genome in days for just a few thousand dollars, ... The pace of research means that genomics, more than almost ...
... LA Research led by Chu Chen, PhD, Associate Professor ... identified an enzyme called Monoacylglycerol lipase (MAGL) as a new ... was published online November 1, 2012 in the Online Now ... team found that inactivation of MAGL, best known for its ...
... Carnegie Institution announced today that it is a grant ... by the Bill & Melinda Gates Foundation. Wolf ... jointly with Bing Yang from Iowa State University and ... global health and development research project entitled "Transformative Strategy ...
Cached Biology News:Bridging the gap between genomics and education 2LSUHSC research identifies new therapeutic target for Alzheimer's disease 2Carnegie Institution for Science receives Grand Challenges Explorations grant 2
(Date:12/17/2014)... 17, 2014 This report is ... Tubing industry. For an overview analysis, the report ... industry chain structure, industry overview, policy analysis, and ... industry has witnessed rapid development with key ... acquisitions. This report mentions quartz tubing upstream raw ...
(Date:12/17/2014)... 2014 Audacity, a leading California-based health ... of the Huntsworth Health Group, is proud to announce ... In her role, Gonzales will serve as Senior Vice ... honored to welcome a talent of Jamie’s caliber to ... Fraikin. “She is a proven healthcare innovation leader and ...
(Date:12/17/2014)... Dec. 17, 2014 CASI Pharmaceuticals, Inc. (Nasdaq: ... the acquisition, development and commercialization of innovative therapeutics addressing ... market with a primary commercial focus on ... granted a Type C meeting with the U.S. Food ... be held in February 2015.  During this meeting the ...
(Date:12/15/2014)... (PRWEB) December 15, 2014 METTLER ... inline PVM tool, ParticleView V19 with PVM ... situ probe-based particle vision and measurement tool continuously ... process conditions. ParticleView V19 then automatically prepares a ... tracking particle size and concentration changes. This compelling ...
Breaking Biology Technology:2020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2
... Defense program , ,MADISON, Wis. Alfalight, Inc. ... percent total power conversion efficiency in its 970 nm ... step toward the eventual goal of 80 percent efficiency ... Agency s Super High Efficiency Diode Sources ...
... Wis. The Wisconsin Virtual School program ... eCollege, to power its online program starting in August ... is a statewide online program based in Tomahawk that ... is designed to enable districts to stretch resources and ...
... way to summer heat, long weekends and beach vacations, we ... nightstand and imagine that we'll have just enough time before ... I had occasion to ask a number of tech executives ... both classic business texts and insightful new offerings in ...
Cached Biology Technology:Alfalight increases laser efficiency for DOD program 2DEMOletter's Summer Reading List 2DEMOletter's Summer Reading List 3DEMOletter's Summer Reading List 4
... The RapidCycler is the first instrument engineered ... and is used by thousands of research ... LightCycler Capillary tubes which are ideally suited ... thin walls and extremely high surface-area-to-volume ratio. ...
Yellow oily liquid. Contains 85% Drakeol 5NF, 15% Arlacel A (mannide monooleate emulsifier). Heat sterilized. Contains zero colony forming units/ml. ...
... miRCURY Array LNA microarray slides for ... microarray slides incorporate Exiqons unique Locked Nucleic ... and excellent mismatch discrimination for short microRNA ... less than 1 g total RNA (no ...
With sodium bicarbonate. Sterile, Cell culture tested...
Biology Products: