Navigation Links
Small RNA plays parallel roles in bacterial metabolism

They are often overlooked, and were once thought to be too small to contribute much to major cellular processes, but in recent years the study of small ribonucleic acids (sRNA) has gained momentum. Now a team from the University of Illinois has identified the unique metabolic activities of one of these bit players, a 200-nucleotide-long RNA molecule in bacteria called SgrS.

This molecule is one of about 80 known small RNAs common to many bacteria. It got its name for its role in sugar metabolism (SgrS is an acronym for sugar-related stress). When a bacterium such as Escherichia coli has taken up enough or too much glucose from its surroundings, SgrS helps stop the transport of glucose molecules across the cell membrane, said microbiology professor and principal investigator Carin Vanderpool.

In trying to tease out how SgrS performs this task, Vanderpool and technician Caryn Wadler discovered that the molecule performs dual roles, both of which inhibit the transport of glucose into the cell. One region of the RNA molecule binds to a messenger RNA to inhibit the production of new glucose transporters, while another region codes for a protein that seems to retard the activity of existing transporters.

The findings appear online this month in the Proceedings of the National Academy of Sciences.

The most novel thing about this discovery is that this molecule seems to be truly bi-functional in that the two functions it performs participate in the same stress response, Vanderpool said.

One other small RNA, a 500-nucleotide molecule that regulates virulence genes in Staphylococcus aureus bacteria, was previously found to encode a protein, Vanderpool said, but the activity of that protein did not participate in the regulation.

The two regions of the molecule were apparently engaged in unrelated tasks.

Some glucose is obviously good, since the bacteria use it to make essential cell molecules and to provide energy. However, excess glucose in bacterial cells interferes with vital functions, Vanderpool said, so the SgrS response is essential to bacterial survival. A deeper understanding of how bacteria defend themselves from metabolic stresses such as excess glucose could lead to important therapeutic innovations, she said.

Vanderpool hopes that more researchers will explore the multifunctional potential of these diminutive molecules.

Dont overlook them just because theyre short, she said.


Contact: Diana Yates
University of Illinois at Urbana-Champaign  

Related biology news :

1. Social parasites of the smaller kind
2. Small animal imaging facility is big boon to research
3. Handbook of small grain insects available now
4. New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed
5. 2007 ozone hole smaller than usual
6. Cilia: small organelles, big decisions
7. Research shows loggerhead sea turtles threatened by small-scale fishing operations
8. Small-scale fishing in Mexico rivals industrial fisheries in accidental turtle deaths
9. Sweet potato shines as new promise for small enterprise and hunger relief in developing countries
10. Identification of a novel class of (not-so) small RNAs
11. Speed plays crucial role in breaking proteins H-bonds
Post Your Comments:
Related Image:
Small RNA plays parallel roles in bacterial metabolism
(Date:11/10/2015)... Nov. 10, 2015 About ... that helps to identify and verify the identity ... considered as the secure and accurate method of ... a particular individual because each individual,s signature is ... especially when dynamic signature of an individual is ...
(Date:11/4/2015)... New York , November 4, 2015 ... to a new market report published by Transparency Market ... Share, Growth, Trends and Forecast 2015 - 2022", the global ... of US$ 30.3 bn by 2022. The market is ... the forecast period from 2015 to 2022. Rising security ...
(Date:10/29/2015)... , Oct. 29, 2015  The J. Craig ... report titled, "DNA Synthesis and Biosecurity: Lessons Learned and ... Department of Health and Human Services guidance for synthetic ... 2010. --> --> ... also has the potential to pose unique biosecurity threats. ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... ... November 25, 2015 , ... ... Organization of Black Aerospace Professionals (OPBAP) has been formalized with the signing of ... team leaders met with OPBAP leaders Capt. Karl Minter and Capt. Albert Glenn ...
(Date:11/24/2015)... Malaysia , Nov. 24, 2015  Asia-Pacific ... contract research organisation (CRO) market. The trend of ... in lower margins but higher volume share for ... capacity and scale, however, margins in the CRO ... Organisation (CRO) Market ( ), finds ...
(Date:11/24/2015)... 2015 /CNW/ - iCo Therapeutics ("iCo" or "the Company") ... for the quarter ended September 30, 2015. Amounts, ... and presented under International Financial Reporting Standards ("IFRS"). ... said Andrew Rae , President & CEO ... not only value enriching for this clinical program, ...
(Date:11/24/2015)... Inc., a worldwide provider of clinical research services headquartered in ... has set a new quarterly earnings record in Q3 of 2015.  ... Q3 of 2014 to Q3 of 2015.   ... the establishment of an Asia-Pacific office to ... and Mexico , with the establishment ...
Breaking Biology Technology: