Navigation Links
Small, beautiful and additive-free
Date:11/13/2009

The National Research Council Canada (NRC) recently helped Olympus, a world leader in advanced optical microscopy and medical imaging, to design and commercialize a CARS (Coherent Anti-stokes Raman Scattering) microscope. A new CARS user facility will open its doors to Canadian researchers and the medical community in Ottawa on November 17, 2009.

The new Olympus microscope is based on a femtosecond non-linear optical process called CARS, which stands for Coherent Anti-Stokes Raman Scattering. CARS is a molecule-specific imaging method that permits researchers to see particular chemicals and structures inside living cells, without adding any dyes or stains: CARS is additive-free! While CARS itself is not new, the NRC team developed a simple, robust yet high performance approach that permitted rapid commercialization. CARS microscopy will now be available to biological and medical researchers in a cost-effective system. New opportunities will abound.

Cells are very small and optical microscopes are required to see them. Unfortunately, the internal components of cells do not come colour-coded for our convenience. To deal with this, scientists have developed, over many decades, various dyes and stains to colour the internal bits of cells so that they could be discerned in an optical microscope. However, if one wants to study processes in live cells busily going about their business, there is a problem. Cellular processes and biochemistry are exceedingly complex and no one knows for sure if these added dyes or stains alter any of these biochemical processes. The best, of course, would be to observe live cells without adding anything at all. Enter CARS microscopy.

CARS is based upon the internal vibrations of molecules. Different molecules have different structures. Due to this, the internal vibrations of these molecules will also be different. CARS recognizes molecules by their "vibrational fingerprint". It is this unique characteristic that allows CARS microscopy to image components inside of cells without adding any dyes or stains.

Compared to Raman microscopy, a well established imaging method that also uses "vibrational fingerprints", CARS is a game changer. For example, a Raman microscopy image that might take 12 hours to scan can now be recorded using CARS microscopy in a second. This allows for real-time movies to be made of live cells and biological tissues.


'/>"/>

Contact: Roxanne DeAbreu-Breen
Roxanne.DeAbreu@olympus.com
905-969-3201
National Research Council of Canada
Source:Eurekalert

Related biology news :

1. Window of opportunity for restoring oaks small, new study finds
2. Beautiful plumage: Feather color and sex start the species revolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/14/2017)... , June 15, 2017  IBM (NYSE: IBM ) ... international tech event dedicated to developing collaboration between startups and ... on June 15-17. During the event, nine startups will showcase ... value in various industries. France ... the international market, with a 30 percent increase in the ...
(Date:5/16/2017)... May 16, 2017  Veratad Technologies, LLC ( www.veratad.com ... age and identity verification solutions, announced today they will ... 2017, May 15 thru May 17, 2017, in ... International Trade Center. Identity impacts the ... in today,s quickly evolving digital world, defining identity is ...
(Date:5/6/2017)... SINGAPORE , May 5, 2017 ... has just announced a new breakthrough in biometric ... that exploits quantum mechanical properties to perform ... new smart semiconductor material created by Ram Group ... across finance, entertainment, transportation, supply chains and security. ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... 10, 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, ... The bold new look is part of a transformation to increase awareness, appeal ... growth period. , It will also expand its service offering from its signature gourmet ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the second time ... US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, D.C. ... US2020. , US2020’s mission is to change the trajectory of STEM education in ...
(Date:10/10/2017)... International research firm Parks Associates announced today that Tom ... 2017 Annual Meeting , October 11 in Scottsdale, Arizona ... and how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM ... firm for the life sciences and healthcare industries, announces a presentation by Subbu ... , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present a ...
Breaking Biology Technology: